Nailfold videocapillaroscopy findings correlate with lung outcomes in idiopathic inflammatory myopathies-related interstitial lung disease

Objectives: Idiopathic inflammatory myopathies (IIM) are a diverse group of muscle diseases often complicated by interstitial lung disease (ILD), which significantly impacts morbidity and mortality. Krebs von den Lungen-6 (sKL-6) has been proposed as a biomarker for ILD severity. Nailfold videocapil...

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Authors: Santos, CS, Tandaipan, JL, Castillo, D, Codes-Mendez, H, Martínez-Martínez, L, Magallares, B, Moya-Alvarado, P, Mariscal, A, Park, HS, Díaz-Torné, C, Fernandez-Sanchez, SP, Bernardez, J, Corominas, H, Alvarez, ED, Castellví, I
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repository:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:dnet:r-iibsantpa_::adcf22e8f51d402b3a4984030970e3f7
Online Access:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21217
Access Level:Open access
Keyword:ILD
biomarkers
IIM
capillaroscopy
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oai_identifier_str oai:dnet:r-iibsantpa_::adcf22e8f51d402b3a4984030970e3f7
network_acronym_str ES
network_name_str España
repository_id_str
spelling Nailfold videocapillaroscopy findings correlate with lung outcomes in idiopathic inflammatory myopathies-related interstitial lung diseaseSantos, CSTandaipan, JLCastillo, DCodes-Mendez, HMartínez-Martínez, LMagallares, BMoya-Alvarado, PMariscal, APark, HSDíaz-Torné, CFernandez-Sanchez, SPBernardez, JCorominas, HAlvarez, EDCastellví, IILDbiomarkersIIMcapillaroscopyObjectives: Idiopathic inflammatory myopathies (IIM) are a diverse group of muscle diseases often complicated by interstitial lung disease (ILD), which significantly impacts morbidity and mortality. Krebs von den Lungen-6 (sKL-6) has been proposed as a biomarker for ILD severity. Nailfold videocapillaroscopy (NVC) detects microvascular changes, but its diagnostic and prognostic value in IIM remains unclear. This study aimed to assess the relationship between NVC abnormalities, sKL-6 levels, and pulmonary outcomes in IIM patients. Methods: A retrospective analysis was conducted in IIM patients from a reference center, comparing those with and without ILD. Data included epidemiological, clinical, and immunological features, pulmonary function tests, sKL-6 levels, and NVC findings. Statistical analyses included Spearman's rank correlation coefficient to assess the relationships between sKL-6 levels, pulmonary function tests, and NVC parameters. Multiple logistic regression modelling to identify to identify predictors of IIM-ILD. Results: Among 95 patients (34% male, median age 55.3 +/- 24 years, disease duration 6.8 +/- 7 years), ILD was associated with avascular zones (p= 0.004), capillary loss (p= 0.04), and microhemorrhages (p= 0.04). Negative correlations were observed between capillary loss and enlarged capillaries with %FVC (rs=-0.46, p= 0.001; rs=-0.57, p< 0.0001) and %DLCO (rs=-0.32, p= 0.04; rs=-0.23, p= 0.03). sKL-6 levels correlated positively with ILD (rs = 0.77, p= 0.0004), microhemorrhages (rs = 0.21, p= 0.04), and avascular areas (rs = 0.64, p= 0.03) and negatively with %FVC (rs=-0.47, p= 0.001) and %DLCO (rs=-0.59, p= 0.005). Predictors of ILD included male sex, respiratory symptoms, %FVC, %DLCO, sKL-6, anti-Jo1 positivity, and NVC abnormalities. Conclusions: NVC findings, sKL-6 levels, and autoantibodies are valuable in identifying and monitoring ILD in IIM, highlighting their role in early diagnosis and management.OXFORD UNIV PRESS2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21217RHEUMATOLOGYISSN: 14620324ISSNe: 14620332reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:dnet:r-iibsantpa_::adcf22e8f51d402b3a4984030970e3f72026-06-14T12:41:47Z
dc.title.none.fl_str_mv Nailfold videocapillaroscopy findings correlate with lung outcomes in idiopathic inflammatory myopathies-related interstitial lung disease
title Nailfold videocapillaroscopy findings correlate with lung outcomes in idiopathic inflammatory myopathies-related interstitial lung disease
spellingShingle Nailfold videocapillaroscopy findings correlate with lung outcomes in idiopathic inflammatory myopathies-related interstitial lung disease
Santos, CS
ILD
biomarkers
IIM
capillaroscopy
title_short Nailfold videocapillaroscopy findings correlate with lung outcomes in idiopathic inflammatory myopathies-related interstitial lung disease
title_full Nailfold videocapillaroscopy findings correlate with lung outcomes in idiopathic inflammatory myopathies-related interstitial lung disease
title_fullStr Nailfold videocapillaroscopy findings correlate with lung outcomes in idiopathic inflammatory myopathies-related interstitial lung disease
title_full_unstemmed Nailfold videocapillaroscopy findings correlate with lung outcomes in idiopathic inflammatory myopathies-related interstitial lung disease
title_sort Nailfold videocapillaroscopy findings correlate with lung outcomes in idiopathic inflammatory myopathies-related interstitial lung disease
dc.creator.none.fl_str_mv Santos, CS
Tandaipan, JL
Castillo, D
Codes-Mendez, H
Martínez-Martínez, L
Magallares, B
Moya-Alvarado, P
Mariscal, A
Park, HS
Díaz-Torné, C
Fernandez-Sanchez, SP
Bernardez, J
Corominas, H
Alvarez, ED
Castellví, I
author Santos, CS
author_facet Santos, CS
Tandaipan, JL
Castillo, D
Codes-Mendez, H
Martínez-Martínez, L
Magallares, B
Moya-Alvarado, P
Mariscal, A
Park, HS
Díaz-Torné, C
Fernandez-Sanchez, SP
Bernardez, J
Corominas, H
Alvarez, ED
Castellví, I
author_role author
author2 Tandaipan, JL
Castillo, D
Codes-Mendez, H
Martínez-Martínez, L
Magallares, B
Moya-Alvarado, P
Mariscal, A
Park, HS
Díaz-Torné, C
Fernandez-Sanchez, SP
Bernardez, J
Corominas, H
Alvarez, ED
Castellví, I
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ILD
biomarkers
IIM
capillaroscopy
topic ILD
biomarkers
IIM
capillaroscopy
description Objectives: Idiopathic inflammatory myopathies (IIM) are a diverse group of muscle diseases often complicated by interstitial lung disease (ILD), which significantly impacts morbidity and mortality. Krebs von den Lungen-6 (sKL-6) has been proposed as a biomarker for ILD severity. Nailfold videocapillaroscopy (NVC) detects microvascular changes, but its diagnostic and prognostic value in IIM remains unclear. This study aimed to assess the relationship between NVC abnormalities, sKL-6 levels, and pulmonary outcomes in IIM patients. Methods: A retrospective analysis was conducted in IIM patients from a reference center, comparing those with and without ILD. Data included epidemiological, clinical, and immunological features, pulmonary function tests, sKL-6 levels, and NVC findings. Statistical analyses included Spearman's rank correlation coefficient to assess the relationships between sKL-6 levels, pulmonary function tests, and NVC parameters. Multiple logistic regression modelling to identify to identify predictors of IIM-ILD. Results: Among 95 patients (34% male, median age 55.3 +/- 24 years, disease duration 6.8 +/- 7 years), ILD was associated with avascular zones (p= 0.004), capillary loss (p= 0.04), and microhemorrhages (p= 0.04). Negative correlations were observed between capillary loss and enlarged capillaries with %FVC (rs=-0.46, p= 0.001; rs=-0.57, p< 0.0001) and %DLCO (rs=-0.32, p= 0.04; rs=-0.23, p= 0.03). sKL-6 levels correlated positively with ILD (rs = 0.77, p= 0.0004), microhemorrhages (rs = 0.21, p= 0.04), and avascular areas (rs = 0.64, p= 0.03) and negatively with %FVC (rs=-0.47, p= 0.001) and %DLCO (rs=-0.59, p= 0.005). Predictors of ILD included male sex, respiratory symptoms, %FVC, %DLCO, sKL-6, anti-Jo1 positivity, and NVC abnormalities. Conclusions: NVC findings, sKL-6 levels, and autoantibodies are valuable in identifying and monitoring ILD in IIM, highlighting their role in early diagnosis and management.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21217
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21217
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv OXFORD UNIV PRESS
publisher.none.fl_str_mv OXFORD UNIV PRESS
dc.source.none.fl_str_mv RHEUMATOLOGY
ISSN: 14620324
ISSNe: 14620332
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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