Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort

Introduction. Repetitive administration of neuropsychological tests can lead to performance improvement merely due to previous exposure. The magnitude of such practice effects (PEs) may be used as a marker of subtle cognitive impairment because they are diminished in healthy individuals subsequently...

Descripción completa

Detalles Bibliográficos
Autores: Sánchez Benavides, Gonzalo, Gispert, Juan Domingo, Fauria, Karine, Molinuevo, José Luis, Gramunt Fombuena, Nina
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/69054
Acceso en línea:http://hdl.handle.net/10230/69054
http://dx.doi.org/10.1016/j.dadm.2016.07.001
Access Level:acceso abierto
Palabra clave:Alzheimer&apos
s disease
Preclinical
Cognition
Practice effects
APOE
Family history
id ES_608a2041b0746bbe00c42e254cfc19b2
oai_identifier_str oai:recercat.cat:10230/69054
network_acronym_str ES
network_name_str España
repository_id_str
spelling Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohortSánchez Benavides, GonzaloGispert, Juan DomingoFauria, KarineMolinuevo, José LuisGramunt Fombuena, NinaAlzheimer&aposs diseasePreclinicalCognitionPractice effectsAPOEFamily historyIntroduction. Repetitive administration of neuropsychological tests can lead to performance improvement merely due to previous exposure. The magnitude of such practice effects (PEs) may be used as a marker of subtle cognitive impairment because they are diminished in healthy individuals subsequently developing Alzheimer's disease (AD). Methods. To explore the relationship between sociodemographic factors, AD family history (FH), and APOE ε4 status, and the magnitude of PE, four subtests of the Wechsler Adult Intelligence Scale-IV were administered twice to 400 middle-aged healthy individuals, most of them first-degree descendants of AD patients. Results. PEs were observed in all measures. Sociodemographic variables did not show a uniform effect on PE. Baseline score was the strongest predictor of change, being inversely related to PE magnitude. Significant effects of the interaction term APOE ε4∗Age in processing speed and working memory were observed. Discussion. PEs exert a relevant effect in cognitive outcomes at retest and, accordingly, they must be taken into consideration in clinical trials. The magnitude of PE in processing speed and working memory could be of special interest for the development of cognitive markers of preclinical AD.Wiley202520252016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/69054http://dx.doi.org/10.1016/j.dadm.2016.07.001reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2016 Jan;4(1):149-58© 2016 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/690542026-05-29T05:05:01Z
dc.title.none.fl_str_mv Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort
title Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort
spellingShingle Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort
Sánchez Benavides, Gonzalo
Alzheimer&apos
s disease
Preclinical
Cognition
Practice effects
APOE
Family history
title_short Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort
title_full Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort
title_fullStr Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort
title_full_unstemmed Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort
title_sort Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort
dc.creator.none.fl_str_mv Sánchez Benavides, Gonzalo
Gispert, Juan Domingo
Fauria, Karine
Molinuevo, José Luis
Gramunt Fombuena, Nina
author Sánchez Benavides, Gonzalo
author_facet Sánchez Benavides, Gonzalo
Gispert, Juan Domingo
Fauria, Karine
Molinuevo, José Luis
Gramunt Fombuena, Nina
author_role author
author2 Gispert, Juan Domingo
Fauria, Karine
Molinuevo, José Luis
Gramunt Fombuena, Nina
author2_role author
author
author
author
dc.subject.none.fl_str_mv Alzheimer&apos
s disease
Preclinical
Cognition
Practice effects
APOE
Family history
topic Alzheimer&apos
s disease
Preclinical
Cognition
Practice effects
APOE
Family history
description Introduction. Repetitive administration of neuropsychological tests can lead to performance improvement merely due to previous exposure. The magnitude of such practice effects (PEs) may be used as a marker of subtle cognitive impairment because they are diminished in healthy individuals subsequently developing Alzheimer's disease (AD). Methods. To explore the relationship between sociodemographic factors, AD family history (FH), and APOE ε4 status, and the magnitude of PE, four subtests of the Wechsler Adult Intelligence Scale-IV were administered twice to 400 middle-aged healthy individuals, most of them first-degree descendants of AD patients. Results. PEs were observed in all measures. Sociodemographic variables did not show a uniform effect on PE. Baseline score was the strongest predictor of change, being inversely related to PE magnitude. Significant effects of the interaction term APOE ε4∗Age in processing speed and working memory were observed. Discussion. PEs exert a relevant effect in cognitive outcomes at retest and, accordingly, they must be taken into consideration in clinical trials. The magnitude of PE in processing speed and working memory could be of special interest for the development of cognitive markers of preclinical AD.
publishDate 2016
dc.date.none.fl_str_mv 2016
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/69054
http://dx.doi.org/10.1016/j.dadm.2016.07.001
url http://hdl.handle.net/10230/69054
http://dx.doi.org/10.1016/j.dadm.2016.07.001
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2016 Jan;4(1):149-58
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409314043592704
score 15,812429

Similares en LA Referencia