Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice

Adverse experiences during infancy and adolescence have an important and enduring effect on the brain and are predisposing factors for mental disorders, particularly major depression. This impact is particularly notable in regions with protracted development, such as the prefrontal cortex. The inhib...

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Autores: Alcaide J, Gramuntell Y, Klimczak P, Bueno-Fernandez C, Garcia-Verellen E, Guicciardini C, Sandi C, Castillo-Gómez E, Crespo C, Perez-Rando M, Nacher J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p18567
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/18567
Access Level:acceso abierto
Palabra clave:Thalamic reticular nucleus
Peripubertal stress
Parvalbumin
Interneurons
Perineuronal nets
PSA-NCAM
NMDA receptors
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spelling Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male miceAlcaide JGramuntell YKlimczak PBueno-Fernandez CGarcia-Verellen EGuicciardini CSandi CCastillo-Gómez ECrespo CPerez-Rando MNacher JThalamic reticular nucleusPeripubertal stressParvalbuminInterneuronsPerineuronal netsPSA-NCAMNMDA receptorsAdverse experiences during infancy and adolescence have an important and enduring effect on the brain and are predisposing factors for mental disorders, particularly major depression. This impact is particularly notable in regions with protracted development, such as the prefrontal cortex. The inhibitory neurons of this cortical region are altered by peripubertal stress (PPS), particularly in female mice. In this study we have explored whether the inhibitory circuits of the thalamus are impacted by PPS in male and female mice. This diencephalic structure, as the prefrontal cortex, also completes its development during postnatal life and is affected by adverse experiences. The long-term changes induced by PPS were exclusively found in adult female mice. We have found that PPS increases depressive-like behavior and induces changes in parvalbumin-expressing (PV+) cells of the thalamic reticular nucleus (TRN). We observed reductions in the volume of the TRN, together with those of parameters related to structures/molecules that regulate the plasticity and connectivity of PV+ cells: perineuronal nets, matricellular structures surrounding PV+ neurons, and the polysialylated form of the neural cell adhesion molecule (PSA-NCAM). The expression of the GluN1, but not of GluN2C, NMDA receptor subunit was augmented in the TRN after PPS. An increase in the fluorescence intensity of PV+ puncta was also observed in the synaptic output of TRN neurons in the lateral posterior thalamic nucleus. These results demonstrate that the inhibitory circuits of the thalamus, as those of the prefrontal cortex, are vulnerable to the effects of aversive experiences during early life, particularly in females. This vulnerability is probably related to the protracted development of the TRN and might contribute to the development of psychiatric disorders.ACADEMIC PRESS INC ELSEVIER SCIENCE2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/18567NEUROBIOLOGY OF DISEASEISSN: 09699961ISSNe: 1095953Xreponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p185672026-06-07T16:35:31Z
dc.title.none.fl_str_mv Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice
title Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice
spellingShingle Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice
Alcaide J
Thalamic reticular nucleus
Peripubertal stress
Parvalbumin
Interneurons
Perineuronal nets
PSA-NCAM
NMDA receptors
title_short Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice
title_full Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice
title_fullStr Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice
title_full_unstemmed Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice
title_sort Long term effects of peripubertal stress on the thalamic reticular nucleus of female and male mice
dc.creator.none.fl_str_mv Alcaide J
Gramuntell Y
Klimczak P
Bueno-Fernandez C
Garcia-Verellen E
Guicciardini C
Sandi C
Castillo-Gómez E
Crespo C
Perez-Rando M
Nacher J
author Alcaide J
author_facet Alcaide J
Gramuntell Y
Klimczak P
Bueno-Fernandez C
Garcia-Verellen E
Guicciardini C
Sandi C
Castillo-Gómez E
Crespo C
Perez-Rando M
Nacher J
author_role author
author2 Gramuntell Y
Klimczak P
Bueno-Fernandez C
Garcia-Verellen E
Guicciardini C
Sandi C
Castillo-Gómez E
Crespo C
Perez-Rando M
Nacher J
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Thalamic reticular nucleus
Peripubertal stress
Parvalbumin
Interneurons
Perineuronal nets
PSA-NCAM
NMDA receptors
topic Thalamic reticular nucleus
Peripubertal stress
Parvalbumin
Interneurons
Perineuronal nets
PSA-NCAM
NMDA receptors
description Adverse experiences during infancy and adolescence have an important and enduring effect on the brain and are predisposing factors for mental disorders, particularly major depression. This impact is particularly notable in regions with protracted development, such as the prefrontal cortex. The inhibitory neurons of this cortical region are altered by peripubertal stress (PPS), particularly in female mice. In this study we have explored whether the inhibitory circuits of the thalamus are impacted by PPS in male and female mice. This diencephalic structure, as the prefrontal cortex, also completes its development during postnatal life and is affected by adverse experiences. The long-term changes induced by PPS were exclusively found in adult female mice. We have found that PPS increases depressive-like behavior and induces changes in parvalbumin-expressing (PV+) cells of the thalamic reticular nucleus (TRN). We observed reductions in the volume of the TRN, together with those of parameters related to structures/molecules that regulate the plasticity and connectivity of PV+ cells: perineuronal nets, matricellular structures surrounding PV+ neurons, and the polysialylated form of the neural cell adhesion molecule (PSA-NCAM). The expression of the GluN1, but not of GluN2C, NMDA receptor subunit was augmented in the TRN after PPS. An increase in the fluorescence intensity of PV+ puncta was also observed in the synaptic output of TRN neurons in the lateral posterior thalamic nucleus. These results demonstrate that the inhibitory circuits of the thalamus, as those of the prefrontal cortex, are vulnerable to the effects of aversive experiences during early life, particularly in females. This vulnerability is probably related to the protracted development of the TRN and might contribute to the development of psychiatric disorders.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/18567
url https://incliva.portalinvestigacion.com/publicaciones/18567
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ACADEMIC PRESS INC ELSEVIER SCIENCE
publisher.none.fl_str_mv ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.source.none.fl_str_mv NEUROBIOLOGY OF DISEASE
ISSN: 09699961
ISSNe: 1095953X
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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