Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM).

A major challenge in human papillomavirus (HPV) vaccine programs is the universal gender-neutral recommendation, as well as estimation of its long-term effect. The objective of this study is to predict the added benefit of male vaccination, especially in men who have sex with men (MSM), and to analy...

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Autores: Díez-Domingo J, Sánchez-Alonso V, Villanueva RJ, Acedo L, Tuells J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p8838
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones8838
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908442/
Access Level:acceso abierto
Palabra clave:*epidemiologic transition
*human papillomavirus
*men who have sex with men
*network model
*sexual behavior
*sexual partners
*vaccination strategies
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spelling Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM).Díez-Domingo JSánchez-Alonso VVillanueva RJAcedo LTuells J*epidemiologic transition*human papillomavirus*men who have sex with men*network model*sexual behavior*sexual partners*vaccination strategiesA major challenge in human papillomavirus (HPV) vaccine programs is the universal gender-neutral recommendation, as well as estimation of its long-term effect. The objective of this study is to predict the added benefit of male vaccination, especially in men who have sex with men (MSM), and to analyze the impact of the program on society. We propose a mathematical model of the HPV infection based on a network paradigm. Data from Spain allowed constructing the sexual network. HPV force of infection was taken from literature. Different scenarios using variable vaccine coverage in both males and females were studied. Strong herd immunity is shown in the heterosexual population, with an important decrease of HPV 6/11 infections both in men and in unvaccinated women with an only-women vaccination at 14 years of age. No impact of this program occurred in the infection incidence in MSM. This group would only benefit from a vaccination program that includes males. However, the impact at short term would be lower than in heterosexual men. The protection of MSM can only be achieved by direct vaccination of males. This may have important consequences for public health.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones8838https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908442/International Journal of Environmental Research and Public HealthISSN: 16617827ISSNe: 16604601reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p88382026-06-12T10:20:37Z
dc.title.none.fl_str_mv Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM).
title Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM).
spellingShingle Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM).
Díez-Domingo J
*epidemiologic transition
*human papillomavirus
*men who have sex with men
*network model
*sexual behavior
*sexual partners
*vaccination strategies
title_short Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM).
title_full Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM).
title_fullStr Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM).
title_full_unstemmed Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM).
title_sort Impact of a Gender-Neutral HPV Vaccination Program in Men Who Have Sex with Men (MSM).
dc.creator.none.fl_str_mv Díez-Domingo J
Sánchez-Alonso V
Villanueva RJ
Acedo L
Tuells J
author Díez-Domingo J
author_facet Díez-Domingo J
Sánchez-Alonso V
Villanueva RJ
Acedo L
Tuells J
author_role author
author2 Sánchez-Alonso V
Villanueva RJ
Acedo L
Tuells J
author2_role author
author
author
author
dc.subject.none.fl_str_mv *epidemiologic transition
*human papillomavirus
*men who have sex with men
*network model
*sexual behavior
*sexual partners
*vaccination strategies
topic *epidemiologic transition
*human papillomavirus
*men who have sex with men
*network model
*sexual behavior
*sexual partners
*vaccination strategies
description A major challenge in human papillomavirus (HPV) vaccine programs is the universal gender-neutral recommendation, as well as estimation of its long-term effect. The objective of this study is to predict the added benefit of male vaccination, especially in men who have sex with men (MSM), and to analyze the impact of the program on society. We propose a mathematical model of the HPV infection based on a network paradigm. Data from Spain allowed constructing the sexual network. HPV force of infection was taken from literature. Different scenarios using variable vaccine coverage in both males and females were studied. Strong herd immunity is shown in the heterosexual population, with an important decrease of HPV 6/11 infections both in men and in unvaccinated women with an only-women vaccination at 14 years of age. No impact of this program occurred in the infection incidence in MSM. This group would only benefit from a vaccination program that includes males. However, the impact at short term would be lower than in heterosexual men. The protection of MSM can only be achieved by direct vaccination of males. This may have important consequences for public health.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones8838
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908442/
url https://isabial.portalinvestigacion.com/publicaciones8838
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908442/
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv International Journal of Environmental Research and Public Health
ISSN: 16617827
ISSNe: 16604601
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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