Editorial: Advancing the development and implementation of regional, national tuberculosis control programs in livestock in Africa, Asia, and Latin America

Tuberculosis (TB) is a multi-host infectious disease caused by members of the Mycobacterium tuberculosis complex (MTC). In Mediterranean ecosystems, where multiple animal hosts of TB are present, identifying the role of the different species involved in the epidemiology of TB is a key point to be ab...

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Detalles Bibliográficos
Autores: Bakker, Douwe, Buza, Joram Josephat, Álvarez Sánchez, Julio, Kapur, Vivek
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/107534
Acceso en línea:https://hdl.handle.net/20.500.14352/107534
Access Level:acceso abierto
Palabra clave:636.09
Animal tuberculosis
Mycobacterium tuberculosis complex
Ovine
Risk factors
Serosurveillance
Veterinaria
3109 Ciencias Veterinarias
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spelling Editorial: Advancing the development and implementation of regional, national tuberculosis control programs in livestock in Africa, Asia, and Latin AmericaBakker, DouweBuza, Joram JosephatÁlvarez Sánchez, JulioKapur, Vivek636.09Animal tuberculosisMycobacterium tuberculosis complexOvineRisk factorsSerosurveillanceVeterinaria3109 Ciencias VeterinariasTuberculosis (TB) is a multi-host infectious disease caused by members of the Mycobacterium tuberculosis complex (MTC). In Mediterranean ecosystems, where multiple animal hosts of TB are present, identifying the role of the different species involved in the epidemiology of TB is a key point to be able to implement proper control measures. Sheep are susceptible to MTC infection but have traditionally been considered a spillover host. However, the occurrence of outbreaks involving sheep in recent years evidences the need to better understand the role of this small ruminant species in the epidemiology of the disease. Here, we aimed to determine the seroprevalence and risk factors associated with MTC seropositivity in sheep in Andalusia (southern Spain), a region with one of the highest prevalence of MTC infection in both cattle and wild ungulates. A total of 2266 sheep from 83 flocks were tested for antibodies against MTC using an in-house indirect ELISA. Anti-MTC antibodies were detected in 16 (0.7%) of the 2266 sheep (adjusted true prevalence 0.29%, 95% posterior probability interval 0.01-1.05). Seropositivity was found in 14.5% (12/83; 95%CI: 6.9-22.0) of the sheep farms analyzed. A semi-extensive management system was identified as a risk factor associated with MTC seropositivity in sheep farms (OR = 3.7; p < 0.038; 95%CI: 1.1-12.4) in the study area. To the best of the authors' knowledge, this is the first active TB surveillance study carried out to assess MTC exposure in sheep. Our results indicate MTC circulation in sheep farms in southern Spain. However, the low individual seroprevalence obtained suggests that sheep may play a limited role in the epidemiology of TB in this region. Serosurveillance programs could be a valuable tool to detect MTC circulation in sheep in risk scenarios or target farms, in order to optimize control measures on TB animal in multi-host Mediterranean ecosystems.Universidad Complutense de Madrid20232023-04-1820232023-04-18journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/107534reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1075342026-06-02T12:44:21Z
dc.title.none.fl_str_mv Editorial: Advancing the development and implementation of regional, national tuberculosis control programs in livestock in Africa, Asia, and Latin America
title Editorial: Advancing the development and implementation of regional, national tuberculosis control programs in livestock in Africa, Asia, and Latin America
spellingShingle Editorial: Advancing the development and implementation of regional, national tuberculosis control programs in livestock in Africa, Asia, and Latin America
Bakker, Douwe
636.09
Animal tuberculosis
Mycobacterium tuberculosis complex
Ovine
Risk factors
Serosurveillance
Veterinaria
3109 Ciencias Veterinarias
title_short Editorial: Advancing the development and implementation of regional, national tuberculosis control programs in livestock in Africa, Asia, and Latin America
title_full Editorial: Advancing the development and implementation of regional, national tuberculosis control programs in livestock in Africa, Asia, and Latin America
title_fullStr Editorial: Advancing the development and implementation of regional, national tuberculosis control programs in livestock in Africa, Asia, and Latin America
title_full_unstemmed Editorial: Advancing the development and implementation of regional, national tuberculosis control programs in livestock in Africa, Asia, and Latin America
title_sort Editorial: Advancing the development and implementation of regional, national tuberculosis control programs in livestock in Africa, Asia, and Latin America
dc.creator.none.fl_str_mv Bakker, Douwe
Buza, Joram Josephat
Álvarez Sánchez, Julio
Kapur, Vivek
author Bakker, Douwe
author_facet Bakker, Douwe
Buza, Joram Josephat
Álvarez Sánchez, Julio
Kapur, Vivek
author_role author
author2 Buza, Joram Josephat
Álvarez Sánchez, Julio
Kapur, Vivek
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 636.09
Animal tuberculosis
Mycobacterium tuberculosis complex
Ovine
Risk factors
Serosurveillance
Veterinaria
3109 Ciencias Veterinarias
topic 636.09
Animal tuberculosis
Mycobacterium tuberculosis complex
Ovine
Risk factors
Serosurveillance
Veterinaria
3109 Ciencias Veterinarias
description Tuberculosis (TB) is a multi-host infectious disease caused by members of the Mycobacterium tuberculosis complex (MTC). In Mediterranean ecosystems, where multiple animal hosts of TB are present, identifying the role of the different species involved in the epidemiology of TB is a key point to be able to implement proper control measures. Sheep are susceptible to MTC infection but have traditionally been considered a spillover host. However, the occurrence of outbreaks involving sheep in recent years evidences the need to better understand the role of this small ruminant species in the epidemiology of the disease. Here, we aimed to determine the seroprevalence and risk factors associated with MTC seropositivity in sheep in Andalusia (southern Spain), a region with one of the highest prevalence of MTC infection in both cattle and wild ungulates. A total of 2266 sheep from 83 flocks were tested for antibodies against MTC using an in-house indirect ELISA. Anti-MTC antibodies were detected in 16 (0.7%) of the 2266 sheep (adjusted true prevalence 0.29%, 95% posterior probability interval 0.01-1.05). Seropositivity was found in 14.5% (12/83; 95%CI: 6.9-22.0) of the sheep farms analyzed. A semi-extensive management system was identified as a risk factor associated with MTC seropositivity in sheep farms (OR = 3.7; p < 0.038; 95%CI: 1.1-12.4) in the study area. To the best of the authors' knowledge, this is the first active TB surveillance study carried out to assess MTC exposure in sheep. Our results indicate MTC circulation in sheep farms in southern Spain. However, the low individual seroprevalence obtained suggests that sheep may play a limited role in the epidemiology of TB in this region. Serosurveillance programs could be a valuable tool to detect MTC circulation in sheep in risk scenarios or target farms, in order to optimize control measures on TB animal in multi-host Mediterranean ecosystems.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-04-18
2023
2023-04-18
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/107534
url https://hdl.handle.net/20.500.14352/107534
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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