Relationship between locus coeruleus and slow-wave sleep in aging and Alzheimer's disease

INTRODUCTION Sleep disruption, particularly loss of slow-wave sleep (SWS), is common in Alzheimer's disease (AD), but its neurobiological underpinnings remain unclear. We investigated whether locus coeruleus (LC) integrity relates to SWS across the AD continuum and whether sex and perivascular...

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Detalles Bibliográficos
Autores: Falgàs, Neus, Tort Colet, Núria, Martín Sobrino, Isabel, Mayà, Gerard, Peña González, Marta, Rudilosso, Salvatore, Gaig, Carles, Bosch, Beatriz, Arqueros, Aurora, Pérez Millan, Agnès, Tort Merino, Adrià, Fernández Villullas, Guadalupe, Piñol Ripoll, Gerard, Balasa, Mircea, Lladó, Albert, Ruiz, Manuel Morales, Muñoz Moreno, Emma, Grau Rivera, Oriol, Iranzo, Alex, Grinberg, Lea, Sánchez Valle, Raquel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/469644
Acceso en línea:https://doi.org/10.1002/alz.71183
https://hdl.handle.net/10459.1/469644
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Locus coeruleus
Neuromodulatory subcortical systems
Perivascular spaces
Sleep
Descripción
Sumario:INTRODUCTION Sleep disruption, particularly loss of slow-wave sleep (SWS), is common in Alzheimer's disease (AD), but its neurobiological underpinnings remain unclear. We investigated whether locus coeruleus (LC) integrity relates to SWS across the AD continuum and whether sex and perivascular spaces (PVSs) modify these associations. METHODS In a cohort (11 controls, 30 mild cognitive impairment, 17 AD dementia) we combined overnight polysomnography with LC-sensitive magnetic resonance imaging of the LC, basal ganglia and centrum semiovale PVS ratings, and cerebrospinal fluid noradrenaline. Multivariable linear regression adjusted for demographics, disease stage, and medication use. RESULTS Higher LC integrity was associated with greater slow-wave activity and slow oscillation power, with stronger effects in females. Basal ganglia PVS burden was related to lower SWS spectral power, whereas noradrenaline levels were not associated with sleep. DISCUSSION LC integrity, sex, and PVS burden show associations with SWS alterations in aging and AD, supporting restorative sleep as a potential therapeutic target.

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