Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders.

Fortea L; Ortuño M; De Prisco M; Oliva V; Albajes-Eizagirre A; Fortea A; Madero S; Solanes A; Vilajosana E; Yao Y; Del Fabro L; Galindo ES; Verdolini N; Farré-Colomés A; Serra-Blasco M; Picó-Pérez M; Lukito S; Wise T; Carlisi C; Arnone D; Kempton M; Hauson AO; Wollman S; Soriano-Mas C; Rubia K; Norman L; Fusar-Poli P; Mataix-Cols D; Valentí M; Via E; Cardoner N; Solmi M; Zhang J; Pan P; Shin JI; Fullana MÀ; Vieta E; Radua J

Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders.

BACKGROUND: Regional gray matter volume (GMV) differences between individuals with mental disorders and comparison participants may be confounded by co-occurring disorders. To disentangle disorder-specific GMV correlates, we conducted a large-scale multidisorder meta-analysis using a novel approach...

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Autores:	Fortea L, Ortuño M, De Prisco M, Oliva V, Albajes-Eizagirre A, Fortea A, Madero S, Solanes A, Vilajosana E, Yao Y, Del Fabro L, Galindo ES, Verdolini N, Farré-Colomés A, Serra-Blasco M, Picó-Pérez M, Lukito S, Wise T, Carlisi C, Arnone D, Kempton M, Hauson AO, Wollman S, Soriano-Mas C, Rubia K, Norman L, Fusar-Poli P, Mataix-Cols D, Valentí M, Via E, Cardoner N, Solmi M, Zhang J, Pan P, Shin JI, Fullana MÀ, Vieta E, Radua J
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2025
País:	España
Institución:	Fundació Sant Joan de Déu
Repositorio:	r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:	oai:fsjd.fundanetsuite.com:p27003
Acceso en línea:	https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=27003
Access Level:	acceso abierto
Palabra clave:	Anxiety disorders Comorbidity Gray matter volume Major depressive disorder Meta-analysis Psychiatric conditions

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spelling	Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders.Fortea LOrtuño MDe Prisco MOliva VAlbajes-Eizagirre AFortea AMadero SSolanes AVilajosana EYao YDel Fabro LGalindo ESVerdolini NFarré-Colomés ASerra-Blasco MPicó-Pérez MLukito SWise TCarlisi CArnone DKempton MHauson AOWollman SSoriano-Mas CRubia KNorman LFusar-Poli PMataix-Cols DValentí MVia ECardoner NSolmi MZhang JPan PShin JIFullana MÀVieta ERadua JAnxiety disordersComorbidityGray matter volumeMajor depressive disorderMeta-analysisPsychiatric conditionsBACKGROUND: Regional gray matter volume (GMV) differences between individuals with mental disorders and comparison participants may be confounded by co-occurring disorders. To disentangle disorder-specific GMV correlates, we conducted a large-scale multidisorder meta-analysis using a novel approach that explicitly models co-occurring disorders. METHODS: We systematically reviewed voxel-based morphometry studies indexed in PubMed and Scopus up to January 2023 that compared adults with major mental disorders (anorexia nervosa, schizophrenia spectrum, anxiety, bipolar, major depressive, obsessive-compulsive, and posttraumatic stress disorders plus attention-deficit/hyperactivity, autism spectrum, and borderline personality disorders) with comparison participants. Two authors independently extracted data and assessed quality using the Newcastle-Ottawa Scale. We derived GMV correlates for each disorder using: 1) a multidisorder meta-analysis that accounted for all co-occurring mental disorders simultaneously and 2) separate standard meta-analyses for each disorder in which co-occurring disorders were ignored. We assessed the alterations' extent, intensity (effect size), and specificity (interdisorder correlations and transdiagnostic alterations) for both approaches. RESULTS: We included 433 studies (499 datasets) involving 19,718 patients and 16,441 comparison participants (51% female, ages 20-67 years). We provide GMV correlate maps for each disorder using both approaches. The novel approach, which accounted for co-occurring disorders, produced GMV correlates that were more focal and disorder specific (less correlated across disorders and fewer transdiagnostic abnormalities). CONCLUSIONS: This work offers the most comprehensive atlas of GMV correlates across major mental disorders. Modeling co-occurring disorders yielded more specific correlates, supporting this approach's validity. The atlas NIfTI maps are available online.ELSEVIER SCIENCE INC2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=27003Biological PsychiatryISSN: 00063223ISSNe: 18732402reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p270032026-05-27T12:37:41Z
dc.title.none.fl_str_mv	Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders.
title	Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders.
spellingShingle	Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders. Fortea L Anxiety disorders Comorbidity Gray matter volume Major depressive disorder Meta-analysis Psychiatric conditions
title_short	Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders.
title_full	Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders.
title_fullStr	Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders.
title_full_unstemmed	Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders.
title_sort	Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders.
dc.creator.none.fl_str_mv	Fortea L Ortuño M De Prisco M Oliva V Albajes-Eizagirre A Fortea A Madero S Solanes A Vilajosana E Yao Y Del Fabro L Galindo ES Verdolini N Farré-Colomés A Serra-Blasco M Picó-Pérez M Lukito S Wise T Carlisi C Arnone D Kempton M Hauson AO Wollman S Soriano-Mas C Rubia K Norman L Fusar-Poli P Mataix-Cols D Valentí M Via E Cardoner N Solmi M Zhang J Pan P Shin JI Fullana MÀ Vieta E Radua J
author	Fortea L
author_facet	Fortea L Ortuño M De Prisco M Oliva V Albajes-Eizagirre A Fortea A Madero S Solanes A Vilajosana E Yao Y Del Fabro L Galindo ES Verdolini N Farré-Colomés A Serra-Blasco M Picó-Pérez M Lukito S Wise T Carlisi C Arnone D Kempton M Hauson AO Wollman S Soriano-Mas C Rubia K Norman L Fusar-Poli P Mataix-Cols D Valentí M Via E Cardoner N Solmi M Zhang J Pan P Shin JI Fullana MÀ Vieta E Radua J
author_role	author
author2	Ortuño M De Prisco M Oliva V Albajes-Eizagirre A Fortea A Madero S Solanes A Vilajosana E Yao Y Del Fabro L Galindo ES Verdolini N Farré-Colomés A Serra-Blasco M Picó-Pérez M Lukito S Wise T Carlisi C Arnone D Kempton M Hauson AO Wollman S Soriano-Mas C Rubia K Norman L Fusar-Poli P Mataix-Cols D Valentí M Via E Cardoner N Solmi M Zhang J Pan P Shin JI Fullana MÀ Vieta E Radua J
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Anxiety disorders Comorbidity Gray matter volume Major depressive disorder Meta-analysis Psychiatric conditions
topic	Anxiety disorders Comorbidity Gray matter volume Major depressive disorder Meta-analysis Psychiatric conditions
description	BACKGROUND: Regional gray matter volume (GMV) differences between individuals with mental disorders and comparison participants may be confounded by co-occurring disorders. To disentangle disorder-specific GMV correlates, we conducted a large-scale multidisorder meta-analysis using a novel approach that explicitly models co-occurring disorders. METHODS: We systematically reviewed voxel-based morphometry studies indexed in PubMed and Scopus up to January 2023 that compared adults with major mental disorders (anorexia nervosa, schizophrenia spectrum, anxiety, bipolar, major depressive, obsessive-compulsive, and posttraumatic stress disorders plus attention-deficit/hyperactivity, autism spectrum, and borderline personality disorders) with comparison participants. Two authors independently extracted data and assessed quality using the Newcastle-Ottawa Scale. We derived GMV correlates for each disorder using: 1) a multidisorder meta-analysis that accounted for all co-occurring mental disorders simultaneously and 2) separate standard meta-analyses for each disorder in which co-occurring disorders were ignored. We assessed the alterations' extent, intensity (effect size), and specificity (interdisorder correlations and transdiagnostic alterations) for both approaches. RESULTS: We included 433 studies (499 datasets) involving 19,718 patients and 16,441 comparison participants (51% female, ages 20-67 years). We provide GMV correlate maps for each disorder using both approaches. The novel approach, which accounted for co-occurring disorders, produced GMV correlates that were more focal and disorder specific (less correlated across disorders and fewer transdiagnostic abnormalities). CONCLUSIONS: This work offers the most comprehensive atlas of GMV correlates across major mental disorders. Modeling co-occurring disorders yielded more specific correlates, supporting this approach's validity. The atlas NIfTI maps are available online.
publishDate	2025
dc.date.none.fl_str_mv	2025
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=27003
url	https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=27003
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	ELSEVIER SCIENCE INC
publisher.none.fl_str_mv	ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv	Biological Psychiatry ISSN: 00063223 ISSNe: 18732402 reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname:Fundació Sant Joan de Déu
instname_str	Fundació Sant Joan de Déu
reponame_str	r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection	r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Atlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders.

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