Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain

Monoaminergic systems, including serotonin, dopamine, and norepinephrine, are essential for regulating brain activity and facilitating behavioral flexibility. These systems originate from brainstem nuclei and project widely to modulate functions such as mood, attention, memory, and adaptability. Usi...

Descripción completa

Detalles Bibliográficos
Autores: Saiz-Masvidal, Cristina, Peña Arteaga, Víctor de la, Bertolín Triquell, Sara, Diez, Ibai, Juaneda Seguí, Asier, Martínez Zalacaín, Ignacio, Chavarría-Elizondo, Pamela, Subirà Coromina, Marta, Menchón Magriñá, José Manuel, Sepulcre, Jorge, 1976-, Fullana Rivas, Miguel Àngel, Soriano Mas, Carles
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/223327
Acceso en línea:https://hdl.handle.net/2445/223327
Access Level:acceso abierto
Palabra clave:Mapatge del cervell
Neurotransmissors
Brain mapping
Neurotransmitters
id ES_5fbddb5e13e3a8ade608fca15ca515c9
oai_identifier_str oai:recercat.cat:2445/223327
network_acronym_str ES
network_name_str España
repository_id_str
spelling Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brainSaiz-Masvidal, CristinaPeña Arteaga, Víctor de laBertolín Triquell, SaraDiez, IbaiJuaneda Seguí, AsierMartínez Zalacaín, IgnacioChavarría-Elizondo, PamelaSubirà Coromina, MartaMenchón Magriñá, José ManuelSepulcre, Jorge, 1976-Fullana Rivas, Miguel ÀngelSoriano Mas, CarlesMapatge del cervellNeurotransmissorsBrain mappingNeurotransmittersMonoaminergic systems, including serotonin, dopamine, and norepinephrine, are essential for regulating brain activity and facilitating behavioral flexibility. These systems originate from brainstem nuclei and project widely to modulate functions such as mood, attention, memory, and adaptability. Using resting-state functional MRI (rs-fMRI), this study aimed to investigate the connectivity networks of key monoaminergic nuclei in 193 healthy adults and explore their correspondence with molecular imaging maps of neurotransmitter-specific biochemical markers. Functional connectivity (FC) was assessed using seed-based rs-fMRI analyses with seeds placed in the dorsal raphe nucleus (DRN), nucleus centralis superior (NCS), ventral tegmental area (VTA), substantia nigra pars compacta (SNc), and locus coeruleus (LC). Cross-modal analyses using molecular imaging data were performed to correlate these rs-FC maps with the distribution of neurotransmitter-related receptors, transporters, and synthesis enzymes, providing insights into the molecular architecture underlying the FC of monoaminergic systems. Whole-brain FC maps revealed distinct patterns for each nucleus. DRN projections were extensive, connecting to subcortical regions such as the hippocampus and amygdala and cortical areas including the precuneus, cingulate, and medial frontal cortex. NCS projections overlapped partially but uniquely targeted the orbitofrontal and insular cortices. Dopaminergic pathways exhibited connectivity with the striatum, thalamus, and prefrontal cortex, while noradrenergic LC projections displayed lateralized connectivity to occipital, temporal, and frontal regions. Cross-modal correlations with molecular imaging demonstrated significant spatial associations between rs-FC maps and neurotransmitter-specific markers, including 5HTT, DAT, and FDOPA. This study enhances our understanding of neurotransmitter networks, highlighting their relevance in brain function and potential as biomarkers for neuropsychiatric conditions.Springer Verlag2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/223327Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1007/s00429-025-02996-4Brain Structure and Function, 2025, vol. 230, num.7, 137https://doi.org/10.1007/s00429-025-02996-4cc by (c) Saiz-Masvidal, Cristina et al., 2025https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2233272026-05-29T05:05:01Z
dc.title.none.fl_str_mv Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
title Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
spellingShingle Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
Saiz-Masvidal, Cristina
Mapatge del cervell
Neurotransmissors
Brain mapping
Neurotransmitters
title_short Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
title_full Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
title_fullStr Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
title_full_unstemmed Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
title_sort Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain
dc.creator.none.fl_str_mv Saiz-Masvidal, Cristina
Peña Arteaga, Víctor de la
Bertolín Triquell, Sara
Diez, Ibai
Juaneda Seguí, Asier
Martínez Zalacaín, Ignacio
Chavarría-Elizondo, Pamela
Subirà Coromina, Marta
Menchón Magriñá, José Manuel
Sepulcre, Jorge, 1976-
Fullana Rivas, Miguel Àngel
Soriano Mas, Carles
author Saiz-Masvidal, Cristina
author_facet Saiz-Masvidal, Cristina
Peña Arteaga, Víctor de la
Bertolín Triquell, Sara
Diez, Ibai
Juaneda Seguí, Asier
Martínez Zalacaín, Ignacio
Chavarría-Elizondo, Pamela
Subirà Coromina, Marta
Menchón Magriñá, José Manuel
Sepulcre, Jorge, 1976-
Fullana Rivas, Miguel Àngel
Soriano Mas, Carles
author_role author
author2 Peña Arteaga, Víctor de la
Bertolín Triquell, Sara
Diez, Ibai
Juaneda Seguí, Asier
Martínez Zalacaín, Ignacio
Chavarría-Elizondo, Pamela
Subirà Coromina, Marta
Menchón Magriñá, José Manuel
Sepulcre, Jorge, 1976-
Fullana Rivas, Miguel Àngel
Soriano Mas, Carles
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mapatge del cervell
Neurotransmissors
Brain mapping
Neurotransmitters
topic Mapatge del cervell
Neurotransmissors
Brain mapping
Neurotransmitters
description Monoaminergic systems, including serotonin, dopamine, and norepinephrine, are essential for regulating brain activity and facilitating behavioral flexibility. These systems originate from brainstem nuclei and project widely to modulate functions such as mood, attention, memory, and adaptability. Using resting-state functional MRI (rs-fMRI), this study aimed to investigate the connectivity networks of key monoaminergic nuclei in 193 healthy adults and explore their correspondence with molecular imaging maps of neurotransmitter-specific biochemical markers. Functional connectivity (FC) was assessed using seed-based rs-fMRI analyses with seeds placed in the dorsal raphe nucleus (DRN), nucleus centralis superior (NCS), ventral tegmental area (VTA), substantia nigra pars compacta (SNc), and locus coeruleus (LC). Cross-modal analyses using molecular imaging data were performed to correlate these rs-FC maps with the distribution of neurotransmitter-related receptors, transporters, and synthesis enzymes, providing insights into the molecular architecture underlying the FC of monoaminergic systems. Whole-brain FC maps revealed distinct patterns for each nucleus. DRN projections were extensive, connecting to subcortical regions such as the hippocampus and amygdala and cortical areas including the precuneus, cingulate, and medial frontal cortex. NCS projections overlapped partially but uniquely targeted the orbitofrontal and insular cortices. Dopaminergic pathways exhibited connectivity with the striatum, thalamus, and prefrontal cortex, while noradrenergic LC projections displayed lateralized connectivity to occipital, temporal, and frontal regions. Cross-modal correlations with molecular imaging demonstrated significant spatial associations between rs-FC maps and neurotransmitter-specific markers, including 5HTT, DAT, and FDOPA. This study enhances our understanding of neurotransmitter networks, highlighting their relevance in brain function and potential as biomarkers for neuropsychiatric conditions.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/223327
url https://hdl.handle.net/2445/223327
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1007/s00429-025-02996-4
Brain Structure and Function, 2025, vol. 230, num.7, 137
https://doi.org/10.1007/s00429-025-02996-4
dc.rights.none.fl_str_mv cc by (c) Saiz-Masvidal, Cristina et al., 2025
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Saiz-Masvidal, Cristina et al., 2025
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409239869423616
score 15,812455

Similares en LA Referencia