Cohort profile: the Spanish Early-onset Colorectal Cancer (SECOC) cohort: a multicentre cohort study on the molecular basis of colorectal cancer among young individuals in Spain

[EN]Purpose The Spanish Early-onset Colorectal Cancer (SECOC) study is a multicentre prospective cohort established in Spain to investigate the molecular basis of early-onset colorectal cancer (EOCRC), including metabolic alterations. Participants 220 patients with EOCRC have been enrolled since Jan...

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Detalles Bibliográficos
Autores: Perea García, José, Martí, Marc, Espin, Eloy, Hernández-Villafranca, Sergio, Orihuela, Pilar, Vidal Tocino, María del Rosario, Alcázar Montero, José Antonio, Vivas, Alfredo, Narvaez, Cristina, Prieto, Isabel, Asensio, Luis, López-Rojo, Irene, Encinas Garcia, Sara, Hurtado, Elena, Jiménez, Luis M., Jiménez, Fernando, Cavero, Adriana, Álvaro, Edurne, Fuenmayor, Maria Luisa, Jiménez-Toscano, Marta, Iglesias Comas, Mar, Balaguer, Francesc, Daca, Maria, Ballestero, Araceli, Die Trill, Javier, Sanz, Gonzalo, Sanz López, Rodrigo, Melone, Sirio, Rueda, Jose A., Brandáriz, Lorena, Valverde, Ignacio, Arredondo, Jorge, Pastor, Carlos, Garcia-Olmo, Damian, Malats, Nuria, Urioste, Miguel, González Sarmiento, Rogelio, Spinelli, Antonino, Holowatyj, Andreana N., Perea, Jose, Marti, Marc, Hernandez-Villafranca, Sergio, López Rojo, Irene, Jiménez, Luis M, Alvaro, Edurne, Jiménez Toscano, Marta, Rueda, Jose A, Brandariz, Lorena, Holowatyj, Andreana N
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/160989
Acceso en línea:http://hdl.handle.net/10366/160989
Access Level:acceso abierto
Palabra clave:Colorectal cancer
Metabolic alterations
Molecular basis
Metabolism, Inborn Errors
Colorectal Neoplasms
Molecular Biology
3207.13 Oncología
3213 Cirugía
biología molecular
neoplasias colorrectales
alteraciones congénitas del metabolismo
Descripción
Sumario:[EN]Purpose The Spanish Early-onset Colorectal Cancer (SECOC) study is a multicentre prospective cohort established in Spain to investigate the molecular basis of early-onset colorectal cancer (EOCRC), including metabolic alterations. Participants 220 patients with EOCRC have been enrolled since January 2019 through 18 centres across Spain. Individual-level data were collected by questionnaire, including lifestyle and other colorectal cancer-related factors. Medical record review was performed to capture clinical, histopathological and familial cancer history data. Biospecimen collection (blood, stool, tissue) at diagnosis and at various time points across treatment, as applicable, is also completed. Findings to date Participants had a median age of 44 years (range 14-49), and the majority are men (60%), with individuals age 40-49 years at EOCRC diagnosis being over-represented. Forty-three per cent of participants were diagnosed with a tumour in the rectosigmoid junction/rectum. Nearly two-thirds of EOCRC cases (64%) were diagnosed with advanced stage (III-IV) disease, and 28% of cases had no reported familial history of cancer. Future plans We are actively recruiting and observing participants; we plan to administer follow-up questionnaires and perform additional biospecimen collection. This prospective cohort offers a unique, rich resource for research on EOCRC aetiologies and will contribute to larger international efforts to disentangle the rising disease burden.

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