Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults

Brain changes occurring in aging can be indexed by biomarkers. We used cluster analysis to identify subgroups of cognitively unimpaired individuals (n ¼ 99, 64e93 years) with different profiles of the cerebrospinal fluid biomarkers beta amyloid 1e42 (Ab42), phosphorylated tau (P-tau), total tau, chi...

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Autores: Idland, Ane Victoria, Sala Llonch, Roser, Watne, Leiv Otto, Braekhus, Anne, Hansson, Oskar, Blennow, Kaj, Zetterberg, Henrik, Sørensen, Øystein, Walhovd, Kristine Beate, Wyller, Torgeir Bruun, Fjell, Anders Martin
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/177677
Acceso en línea:https://hdl.handle.net/2445/177677
Access Level:acceso abierto
Palabra clave:Líquid cefalorraquidi
Memòria
Marcadors bioquímics
Cerebrospinal fluid
Memory
Biochemical markers
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spelling Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adultsIdland, Ane VictoriaSala Llonch, RoserWatne, Leiv OttoBraekhus, AnneHansson, OskarBlennow, KajZetterberg, HenrikSørensen, ØysteinWalhovd, Kristine BeateWyller, Torgeir BruunFjell, Anders MartinLíquid cefalorraquidiMemòriaMarcadors bioquímicsCerebrospinal fluidMemoryBiochemical markersBrain changes occurring in aging can be indexed by biomarkers. We used cluster analysis to identify subgroups of cognitively unimpaired individuals (n ¼ 99, 64e93 years) with different profiles of the cerebrospinal fluid biomarkers beta amyloid 1e42 (Ab42), phosphorylated tau (P-tau), total tau, chitinase-3-like protein 1 (YKL-40), fatty acid binding protein 3 (FABP3), and neurofilament light (NFL). Hippocampal volume and memory were assessed across multiple follow-up examinations covering up to 6.8 years. Clustering revealed one group (39%) with more pathological concentrations of all biomarkers, which could further be divided into one group (20%) characterized by tauopathy and high FABP3 and one (19%) by brain b-amyloidosis, high NFL, and slightly higher YKL-40. The clustering approach clearly outperformed classification based on Ab42 and P-tau alone in prediction of memory decline, with the individuals with most tauopathy and FABP3 showing more memory decline, but not more hippocampal volume change. The results demonstrate that older adults can be classified based on biomarkers beyond amyloid and tau, with improved prediction of memory decline.Elsevier B.V.2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/177677Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.neurobiolaging.2020.04.002Neurobiology of Aging, 2020, vol. 93, pp. 1-15https://doi.org/10.1016/j.neurobiolaging.2020.04.002cc-by (c) Idland et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1776772026-05-27T06:46:51Z
dc.title.none.fl_str_mv Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
title Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
spellingShingle Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
Idland, Ane Victoria
Líquid cefalorraquidi
Memòria
Marcadors bioquímics
Cerebrospinal fluid
Memory
Biochemical markers
title_short Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
title_full Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
title_fullStr Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
title_full_unstemmed Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
title_sort Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
dc.creator.none.fl_str_mv Idland, Ane Victoria
Sala Llonch, Roser
Watne, Leiv Otto
Braekhus, Anne
Hansson, Oskar
Blennow, Kaj
Zetterberg, Henrik
Sørensen, Øystein
Walhovd, Kristine Beate
Wyller, Torgeir Bruun
Fjell, Anders Martin
author Idland, Ane Victoria
author_facet Idland, Ane Victoria
Sala Llonch, Roser
Watne, Leiv Otto
Braekhus, Anne
Hansson, Oskar
Blennow, Kaj
Zetterberg, Henrik
Sørensen, Øystein
Walhovd, Kristine Beate
Wyller, Torgeir Bruun
Fjell, Anders Martin
author_role author
author2 Sala Llonch, Roser
Watne, Leiv Otto
Braekhus, Anne
Hansson, Oskar
Blennow, Kaj
Zetterberg, Henrik
Sørensen, Øystein
Walhovd, Kristine Beate
Wyller, Torgeir Bruun
Fjell, Anders Martin
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Líquid cefalorraquidi
Memòria
Marcadors bioquímics
Cerebrospinal fluid
Memory
Biochemical markers
topic Líquid cefalorraquidi
Memòria
Marcadors bioquímics
Cerebrospinal fluid
Memory
Biochemical markers
description Brain changes occurring in aging can be indexed by biomarkers. We used cluster analysis to identify subgroups of cognitively unimpaired individuals (n ¼ 99, 64e93 years) with different profiles of the cerebrospinal fluid biomarkers beta amyloid 1e42 (Ab42), phosphorylated tau (P-tau), total tau, chitinase-3-like protein 1 (YKL-40), fatty acid binding protein 3 (FABP3), and neurofilament light (NFL). Hippocampal volume and memory were assessed across multiple follow-up examinations covering up to 6.8 years. Clustering revealed one group (39%) with more pathological concentrations of all biomarkers, which could further be divided into one group (20%) characterized by tauopathy and high FABP3 and one (19%) by brain b-amyloidosis, high NFL, and slightly higher YKL-40. The clustering approach clearly outperformed classification based on Ab42 and P-tau alone in prediction of memory decline, with the individuals with most tauopathy and FABP3 showing more memory decline, but not more hippocampal volume change. The results demonstrate that older adults can be classified based on biomarkers beyond amyloid and tau, with improved prediction of memory decline.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/177677
url https://hdl.handle.net/2445/177677
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.neurobiolaging.2020.04.002
Neurobiology of Aging, 2020, vol. 93, pp. 1-15
https://doi.org/10.1016/j.neurobiolaging.2020.04.002
dc.rights.none.fl_str_mv cc-by (c) Idland et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Idland et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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