An effort to make sense of antisense transcription in bacteria

This is an accepted manuscript of an article published by Taylor & Francis in RNA Biology on August 1st 2012, available online: http://dx.doi.org/10.4161/rna.21167.

Detalles Bibliográficos
Autores: Lasa Uzcudun, Íñigo, Toledo Arana, Alejandro, Gingeras, Thomas R.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2012
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/22581
Acceso en línea:https://hdl.handle.net/2454/22581
Access Level:acceso abierto
Palabra clave:Overlapping transcription
RNase III
RNA processing
Bacteria
Transcriptome
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spelling An effort to make sense of antisense transcription in bacteriaLasa Uzcudun, ÍñigoToledo Arana, AlejandroGingeras, Thomas R.Overlapping transcriptionRNase IIIRNA processingBacteriaTranscriptomeThis is an accepted manuscript of an article published by Taylor & Francis in RNA Biology on August 1st 2012, available online: http://dx.doi.org/10.4161/rna.21167.Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some portion of the 5′- and 3′-UTR regions. The biological advantages of such overlapping transcription are unclear but may play important regulatory roles at the level of transcription, RNA stability and translation. In a recent report, the human pathogen Staphylococcus aureus is observed to generate genome-wide overlapping transcription in the same bacterial cells leading to a collection of short RNA fragments generated by the endoribonuclease III, RNase III. This processing appears most prominently in Gram-positive bacteria. The implications of both the use of pervasive overlapping transcription and the processing of these double stranded templates into short RNAs are explored and the consequences discussed.A.T.-A. is recipient of “Ramon y Cajal” contracts from the Spanish Ministry of Science and Innovation. This research was supported by grants ERA-NET Pathogenomics (PIM2010EPA-00606), BIO2008-05284-C02, BIO2011-30503-C02 and BFU2011-23222 from Spanish Ministry of Economy and Competitiveness.Taylor & FrancisIdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2454/22581reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/MICINN//BIO2008-05284-C02-01info:eu-repo/grantAgreement/MICINN//BIO2011-30503-C02-02info:eu-repo/grantAgreement/ES/6PN/BFU2011-23222© 2012 Landes Bioscienceinfo:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/225812026-06-17T12:41:47Z
dc.title.none.fl_str_mv An effort to make sense of antisense transcription in bacteria
title An effort to make sense of antisense transcription in bacteria
spellingShingle An effort to make sense of antisense transcription in bacteria
Lasa Uzcudun, Íñigo
Overlapping transcription
RNase III
RNA processing
Bacteria
Transcriptome
title_short An effort to make sense of antisense transcription in bacteria
title_full An effort to make sense of antisense transcription in bacteria
title_fullStr An effort to make sense of antisense transcription in bacteria
title_full_unstemmed An effort to make sense of antisense transcription in bacteria
title_sort An effort to make sense of antisense transcription in bacteria
dc.creator.none.fl_str_mv Lasa Uzcudun, Íñigo
Toledo Arana, Alejandro
Gingeras, Thomas R.
author Lasa Uzcudun, Íñigo
author_facet Lasa Uzcudun, Íñigo
Toledo Arana, Alejandro
Gingeras, Thomas R.
author_role author
author2 Toledo Arana, Alejandro
Gingeras, Thomas R.
author2_role author
author
dc.contributor.none.fl_str_mv IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua
dc.subject.none.fl_str_mv Overlapping transcription
RNase III
RNA processing
Bacteria
Transcriptome
topic Overlapping transcription
RNase III
RNA processing
Bacteria
Transcriptome
description This is an accepted manuscript of an article published by Taylor & Francis in RNA Biology on August 1st 2012, available online: http://dx.doi.org/10.4161/rna.21167.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/22581
url https://hdl.handle.net/2454/22581
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN//BIO2008-05284-C02-01
info:eu-repo/grantAgreement/MICINN//BIO2011-30503-C02-02
info:eu-repo/grantAgreement/ES/6PN/BFU2011-23222
dc.rights.none.fl_str_mv © 2012 Landes Bioscience
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © 2012 Landes Bioscience
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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