Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain
Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers d...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2020 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositório: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglês |
| OAI Identifier: | oai:ddd.uab.cat:252599 |
| Acesso em linha: | https://ddd.uab.cat/record/252599 https://dx.doi.org/urn:doi:10.3390/pathogens9050352 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Zika virus Microcephaly Congenital infection Adverse outcome Arboviruses |
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Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in SpainSoriano-Arandes, Antoni|||0000-0001-9613-7228Frick, Marie Antoinette|||0000-0002-2553-5090García López-Hortelano, MilagrosSulleiro, Elena|||0000-0002-9783-6060Rodó, Carlota|||0000-0001-8801-5677Sánchez-Seco, María PazCabrera-Lafuente, MartaSuy, Anna|||0000-0003-2987-6105De la Calle, MaríaSantos, MarAntolin, EugeniaViñuela, María del CarmenEspiau, María|||0000-0001-9697-7649Salazar, AinaraGuarch-Ibáñez, Borja|||0000-0002-8601-0191Vázquez González, Ana|||0000-0002-9872-3316Navarro-Morón, JuanRamos Amador, José TomásMartín-Nalda, Andrea|||0000-0002-1715-153XDueñas, EvaBlázquez-Gamero, Daniel|||0000-0001-6483-8329Reques-Cosme, ResurrecciónOlabarrieta, IciarPrieto, LuisDe Ory, Fernando|||0000-0002-6981-1261Thorne, ClaireByrne, ThomasAdes, Anthony E.Ruiz-Burga, Elisa|||0000-0002-0529-0372Giaquinto, CarloGarcia-Alix, Alfredo|||0000-0002-7972-8453Carreras Moratonas, Elena|||0000-0003-3471-7248Soler-Palacín, Pere|||0000-0002-0346-5570Zika virusMicrocephalyCongenital infectionAdverse outcomeArbovirusesBackground: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4-6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4-39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations.Universitat Autònoma de Barcelona 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/252599https://dx.doi.org/urn:doi:10.3390/pathogens9050352reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 73485open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2525992026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain |
| title |
Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain |
| spellingShingle |
Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain Soriano-Arandes, Antoni|||0000-0001-9613-7228 Zika virus Microcephaly Congenital infection Adverse outcome Arboviruses |
| title_short |
Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain |
| title_full |
Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain |
| title_fullStr |
Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain |
| title_full_unstemmed |
Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain |
| title_sort |
Clinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spain |
| dc.creator.none.fl_str_mv |
Soriano-Arandes, Antoni|||0000-0001-9613-7228 Frick, Marie Antoinette|||0000-0002-2553-5090 García López-Hortelano, Milagros Sulleiro, Elena|||0000-0002-9783-6060 Rodó, Carlota|||0000-0001-8801-5677 Sánchez-Seco, María Paz Cabrera-Lafuente, Marta Suy, Anna|||0000-0003-2987-6105 De la Calle, María Santos, Mar Antolin, Eugenia Viñuela, María del Carmen Espiau, María|||0000-0001-9697-7649 Salazar, Ainara Guarch-Ibáñez, Borja|||0000-0002-8601-0191 Vázquez González, Ana|||0000-0002-9872-3316 Navarro-Morón, Juan Ramos Amador, José Tomás Martín-Nalda, Andrea|||0000-0002-1715-153X Dueñas, Eva Blázquez-Gamero, Daniel|||0000-0001-6483-8329 Reques-Cosme, Resurrección Olabarrieta, Iciar Prieto, Luis De Ory, Fernando|||0000-0002-6981-1261 Thorne, Claire Byrne, Thomas Ades, Anthony E. Ruiz-Burga, Elisa|||0000-0002-0529-0372 Giaquinto, Carlo Garcia-Alix, Alfredo|||0000-0002-7972-8453 Carreras Moratonas, Elena|||0000-0003-3471-7248 Soler-Palacín, Pere|||0000-0002-0346-5570 |
| author |
Soriano-Arandes, Antoni|||0000-0001-9613-7228 |
| author_facet |
Soriano-Arandes, Antoni|||0000-0001-9613-7228 Frick, Marie Antoinette|||0000-0002-2553-5090 García López-Hortelano, Milagros Sulleiro, Elena|||0000-0002-9783-6060 Rodó, Carlota|||0000-0001-8801-5677 Sánchez-Seco, María Paz Cabrera-Lafuente, Marta Suy, Anna|||0000-0003-2987-6105 De la Calle, María Santos, Mar Antolin, Eugenia Viñuela, María del Carmen Espiau, María|||0000-0001-9697-7649 Salazar, Ainara Guarch-Ibáñez, Borja|||0000-0002-8601-0191 Vázquez González, Ana|||0000-0002-9872-3316 Navarro-Morón, Juan Ramos Amador, José Tomás Martín-Nalda, Andrea|||0000-0002-1715-153X Dueñas, Eva Blázquez-Gamero, Daniel|||0000-0001-6483-8329 Reques-Cosme, Resurrección Olabarrieta, Iciar Prieto, Luis De Ory, Fernando|||0000-0002-6981-1261 Thorne, Claire Byrne, Thomas Ades, Anthony E. Ruiz-Burga, Elisa|||0000-0002-0529-0372 Giaquinto, Carlo Garcia-Alix, Alfredo|||0000-0002-7972-8453 Carreras Moratonas, Elena|||0000-0003-3471-7248 Soler-Palacín, Pere|||0000-0002-0346-5570 |
| author_role |
author |
| author2 |
Frick, Marie Antoinette|||0000-0002-2553-5090 García López-Hortelano, Milagros Sulleiro, Elena|||0000-0002-9783-6060 Rodó, Carlota|||0000-0001-8801-5677 Sánchez-Seco, María Paz Cabrera-Lafuente, Marta Suy, Anna|||0000-0003-2987-6105 De la Calle, María Santos, Mar Antolin, Eugenia Viñuela, María del Carmen Espiau, María|||0000-0001-9697-7649 Salazar, Ainara Guarch-Ibáñez, Borja|||0000-0002-8601-0191 Vázquez González, Ana|||0000-0002-9872-3316 Navarro-Morón, Juan Ramos Amador, José Tomás Martín-Nalda, Andrea|||0000-0002-1715-153X Dueñas, Eva Blázquez-Gamero, Daniel|||0000-0001-6483-8329 Reques-Cosme, Resurrección Olabarrieta, Iciar Prieto, Luis De Ory, Fernando|||0000-0002-6981-1261 Thorne, Claire Byrne, Thomas Ades, Anthony E. Ruiz-Burga, Elisa|||0000-0002-0529-0372 Giaquinto, Carlo Garcia-Alix, Alfredo|||0000-0002-7972-8453 Carreras Moratonas, Elena|||0000-0003-3471-7248 Soler-Palacín, Pere|||0000-0002-0346-5570 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Zika virus Microcephaly Congenital infection Adverse outcome Arboviruses |
| topic |
Zika virus Microcephaly Congenital infection Adverse outcome Arboviruses |
| description |
Background: Zika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. Methods: This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. Results: ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4-6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4-39.6%). Conclusions: A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2 2020-01-01 2020 2020-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/252599 https://dx.doi.org/urn:doi:10.3390/pathogens9050352 |
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https://ddd.uab.cat/record/252599 https://dx.doi.org/urn:doi:10.3390/pathogens9050352 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
European Commission https://doi.org/10.13039/501100000780 73485 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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