Genetic affinities among the historical provinces of Romania and Central Europe as revealed by an mtDNA analysis

Background: As a major crossroads between Asia and Europe, Romania has experienced continuous migration and invasion episodes. The precise routes may have been shaped by the topology of the territory and had diverse impacts on the genetic structure of mitochondrial DNA (mtDNA) in historical Romanian...

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Autores: Cocoş, Relu, Schipor, Sorina, Hervella Afonso, Montserrat, Cianga, Petru, Popescu, Roxana, Bănescu, Claudia, Constantinescu, Mihai, Martinescu, Alina, Raicu, Florina
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/32363
Acceso en línea:http://hdl.handle.net/10810/32363
Access Level:acceso abierto
Palabra clave:mitochondrial DNA
romanian provinces
genetic diversityr
Transylvania
human mitochondrial-DNA
region
sequence
haplogroups
landscape
lineages
genome
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spelling Genetic affinities among the historical provinces of Romania and Central Europe as revealed by an mtDNA analysisCocoş, ReluSchipor, SorinaHervella Afonso, MontserratCianga, PetruPopescu, RoxanaBănescu, ClaudiaConstantinescu, MihaiMartinescu, AlinaRaicu, Florinamitochondrial DNAromanian provincesgenetic diversityrTransylvaniahuman mitochondrial-DNAregionsequencehaplogroupslandscapelineagesgenomeBackground: As a major crossroads between Asia and Europe, Romania has experienced continuous migration and invasion episodes. The precise routes may have been shaped by the topology of the territory and had diverse impacts on the genetic structure of mitochondrial DNA (mtDNA) in historical Romanian provinces. We studied 714 Romanians from all historical provinces, Wallachia, Dobrudja, Moldavia, and Transylvania, by analyzing the mtDNA control region and coding markers to encompass the complete landscape of mtDNA haplogroups. Results: We observed a homogenous distribution of the majority of haplogroups among the Romanian provinces and a clear association with the European populations. A principal component analysis and multidimensional scaling analysis supported the genetic similarity of the Wallachia, Moldavia, and Dobrudja groups with the Balkans, while the Transylvania population was closely related to Central European groups. These findings could be explained by the topology of the Romanian territory, where the Carpathian Arch played an important role in migration patterns. Signals of Asian maternal lineages were observed in all Romanian historical provinces, indicating gene flow along the migration routes through East Asia and Europe. Conclusions: Our current findings based on the mtDNA analysis of populations in historical provinces of Romania suggest similarity between populations in Transylvania and Central Europe, supported both by the observed clines in haplogroup frequencies for several European and Asian maternal lineages and MDS analyses.This work was supported by grants two grants of the Romanian National Authority for Scientific Research, CNCS-UEFISCDI, project numbers PN-II-RU-TE-2014-4-0527 and PN-II-ID-PCCE 2011-2-0013; and by the Spanish Ministry of Science and Innovation (GCL2016-79093/P, Basque Government to Research Groups (IT1138-16) and University of the Basque Country-UPV/EHU (UFI 11/09). The funders had no role in the study design, collection, analysis and interpretation of data, or in the writing of the report or decision to submit the article for publication.Biomed Central201920192017info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/32363reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://bmcgenet.biomedcentral.com/articles/10.1186/s12863-017-0487-5info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Atribución 3.0 Españaoai:addi.ehu.eus:10810/323632026-06-18T09:23:17Z
dc.title.none.fl_str_mv Genetic affinities among the historical provinces of Romania and Central Europe as revealed by an mtDNA analysis
title Genetic affinities among the historical provinces of Romania and Central Europe as revealed by an mtDNA analysis
spellingShingle Genetic affinities among the historical provinces of Romania and Central Europe as revealed by an mtDNA analysis
Cocoş, Relu
mitochondrial DNA
romanian provinces
genetic diversityr
Transylvania
human mitochondrial-DNA
region
sequence
haplogroups
landscape
lineages
genome
title_short Genetic affinities among the historical provinces of Romania and Central Europe as revealed by an mtDNA analysis
title_full Genetic affinities among the historical provinces of Romania and Central Europe as revealed by an mtDNA analysis
title_fullStr Genetic affinities among the historical provinces of Romania and Central Europe as revealed by an mtDNA analysis
title_full_unstemmed Genetic affinities among the historical provinces of Romania and Central Europe as revealed by an mtDNA analysis
title_sort Genetic affinities among the historical provinces of Romania and Central Europe as revealed by an mtDNA analysis
dc.creator.none.fl_str_mv Cocoş, Relu
Schipor, Sorina
Hervella Afonso, Montserrat
Cianga, Petru
Popescu, Roxana
Bănescu, Claudia
Constantinescu, Mihai
Martinescu, Alina
Raicu, Florina
author Cocoş, Relu
author_facet Cocoş, Relu
Schipor, Sorina
Hervella Afonso, Montserrat
Cianga, Petru
Popescu, Roxana
Bănescu, Claudia
Constantinescu, Mihai
Martinescu, Alina
Raicu, Florina
author_role author
author2 Schipor, Sorina
Hervella Afonso, Montserrat
Cianga, Petru
Popescu, Roxana
Bănescu, Claudia
Constantinescu, Mihai
Martinescu, Alina
Raicu, Florina
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv mitochondrial DNA
romanian provinces
genetic diversityr
Transylvania
human mitochondrial-DNA
region
sequence
haplogroups
landscape
lineages
genome
topic mitochondrial DNA
romanian provinces
genetic diversityr
Transylvania
human mitochondrial-DNA
region
sequence
haplogroups
landscape
lineages
genome
description Background: As a major crossroads between Asia and Europe, Romania has experienced continuous migration and invasion episodes. The precise routes may have been shaped by the topology of the territory and had diverse impacts on the genetic structure of mitochondrial DNA (mtDNA) in historical Romanian provinces. We studied 714 Romanians from all historical provinces, Wallachia, Dobrudja, Moldavia, and Transylvania, by analyzing the mtDNA control region and coding markers to encompass the complete landscape of mtDNA haplogroups. Results: We observed a homogenous distribution of the majority of haplogroups among the Romanian provinces and a clear association with the European populations. A principal component analysis and multidimensional scaling analysis supported the genetic similarity of the Wallachia, Moldavia, and Dobrudja groups with the Balkans, while the Transylvania population was closely related to Central European groups. These findings could be explained by the topology of the Romanian territory, where the Carpathian Arch played an important role in migration patterns. Signals of Asian maternal lineages were observed in all Romanian historical provinces, indicating gene flow along the migration routes through East Asia and Europe. Conclusions: Our current findings based on the mtDNA analysis of populations in historical provinces of Romania suggest similarity between populations in Transylvania and Central Europe, supported both by the observed clines in haplogroup frequencies for several European and Asian maternal lineages and MDS analyses.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/32363
url http://hdl.handle.net/10810/32363
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://bmcgenet.biomedcentral.com/articles/10.1186/s12863-017-0487-5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
Atribución 3.0 España
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Biomed Central
publisher.none.fl_str_mv Biomed Central
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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