Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil

16 páginas, 5 tablas y 3 figuras

Detalles Bibliográficos
Autores: Carro, Lorena, Franco Castro, Jean, Razmilic, Valeria, Nouioui, Imen, Pan, Che, Igual, José Mariano, Jaspars, Marcel, Goodfellow, Michael, Bull, Alan T., Asenjo, Juan A., Klenk, Hans Peter
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/178680
Acceso en línea:http://hdl.handle.net/10261/178680
Access Level:acceso abierto
Palabra clave:Soil
Atacama Desert
Novel micromonosporae
id ES_5f7ec7025c7cf3de6bc6e6268cfee4cd
oai_identifier_str oai:digital.csic.es:10261/178680
network_acronym_str ES
network_name_str España
repository_id_str
spelling Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soilCarro, LorenaFranco Castro, JeanRazmilic, ValeriaNouioui, ImenPan, CheIgual, José MarianoJaspars, MarcelGoodfellow, MichaelBull, Alan T.Asenjo, Juan A.Klenk, Hans PeterSoilAtacama DesertNovel micromonosporae16 páginas, 5 tablas y 3 figurasThe taxonomic status, biotechnological and ecological potential of several Micromonospora strains isolated from an extreme hyper arid Atacama Desert soil were determined. Initially, a polyphasic study was undertaken to clarify the taxonomic status of five micromonosporae, strains LB4, LB19, LB32 T , LB39 T and LB41, isolated from an extreme hyper-arid soil collected from one of the driest regions of the Atacama Desert. All of the isolates were found to have chemotaxonomic, cultural and morphological properties consistent with their classification in the genus Micromonospora. Isolates LB32 T and LB39 T were distinguished from their nearest phylogenetic neighbours and proposed as new species, namely as Micromonospora arida sp. nov. and Micromonospora inaquosa sp. nov., respectively. Eluted methanol extracts of all of the isolates showed activity against a panel of bacterial and fungal indicator strains, notably against multi-drug resistant Klebsiella pneumoniae ATCC 700603 while isolates LB4 and LB41 showed pronounced anti-tumour activity against HepG2 cells. Draft genomes generated for the isolates revealed a rich source of novel biosynthetic gene clusters, some of which were unique to individual strains thereby opening up the prospect of selecting especially gifted micromonosporae for natural product discovery. Key stress-related genes detected in the genomes of all of the isolates provided an insight into how micromonosporae adapt to the harsh environmental conditions that prevail in extreme hyper-arid Atacama Desert soils.This project was partly funded by a UK-Newton Project for UK-Chile collaboration (JIC CA 586) and by support from the Basal Programme of CONICYT for the Centre for Biotechnology and Bioengineering (CeBiB) (project FB0001). IN and LC thank Newcastle University for postdoctoral fellowships and ATB and MG are indebted to the Leverhulme Trust for Emeritus Fellowships. LC thanks the University of Salamanca for a postdoctoral fellowship.Peer reviewedSpringer NatureComisión Nacional de Investigación Científica y Tecnológica (Chile)Igual, José Mariano [0000-0002-5080-0378]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/178680reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1038/s41598-019-38789-zSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1786802026-05-22T06:33:51Z
dc.title.none.fl_str_mv Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil
title Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil
spellingShingle Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil
Carro, Lorena
Soil
Atacama Desert
Novel micromonosporae
title_short Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil
title_full Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil
title_fullStr Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil
title_full_unstemmed Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil
title_sort Uncovering the potential of novel micromonosporae isolated from an extreme hyper-arid Atacama Desert soil
dc.creator.none.fl_str_mv Carro, Lorena
Franco Castro, Jean
Razmilic, Valeria
Nouioui, Imen
Pan, Che
Igual, José Mariano
Jaspars, Marcel
Goodfellow, Michael
Bull, Alan T.
Asenjo, Juan A.
Klenk, Hans Peter
author Carro, Lorena
author_facet Carro, Lorena
Franco Castro, Jean
Razmilic, Valeria
Nouioui, Imen
Pan, Che
Igual, José Mariano
Jaspars, Marcel
Goodfellow, Michael
Bull, Alan T.
Asenjo, Juan A.
Klenk, Hans Peter
author_role author
author2 Franco Castro, Jean
Razmilic, Valeria
Nouioui, Imen
Pan, Che
Igual, José Mariano
Jaspars, Marcel
Goodfellow, Michael
Bull, Alan T.
Asenjo, Juan A.
Klenk, Hans Peter
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Comisión Nacional de Investigación Científica y Tecnológica (Chile)
Igual, José Mariano [0000-0002-5080-0378]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Soil
Atacama Desert
Novel micromonosporae
topic Soil
Atacama Desert
Novel micromonosporae
description 16 páginas, 5 tablas y 3 figuras
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/178680
url http://hdl.handle.net/10261/178680
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1038/s41598-019-38789-z
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869409211051409408
score 15.812429

Similares en LA Referencia