Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults.

Background Among people who have suffered a traumatic brain injury, increased intracranial pressure continues to be a major cause of early death; it is estimated that about 11 people per 100 with traumatic brain injury die. Indomethacin (also known as indometacin) is a powerful cerebral vasoconstric...

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Autores: Martín Saborido, Carlos, López Alcalde, Jesús, Ciapponi, Agustín, Sánchez Martín, Carlos Enrique, Garcia Garcia, Elena, Escobar Aguilar, Gema, Palermo, Maria Carolina, Baccaro, Fernando G
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Francisco de Vitoria
Repositorio:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
Idioma:inglés
OAI Identifier:oai:ddfv.ufv.es:10641/1798
Acceso en línea:http://hdl.handle.net/10641/1798
Access Level:acceso abierto
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spelling Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults.Martín Saborido, CarlosLópez Alcalde, JesúsCiapponi, AgustínSánchez Martín, Carlos EnriqueGarcia Garcia, ElenaEscobar Aguilar, GemaPalermo, Maria CarolinaBaccaro, Fernando GBackground Among people who have suffered a traumatic brain injury, increased intracranial pressure continues to be a major cause of early death; it is estimated that about 11 people per 100 with traumatic brain injury die. Indomethacin (also known as indometacin) is a powerful cerebral vasoconstrictor that can reduce intracranial pressure and, ultimately, restore cerebral perfusion and oxygenation. Thus, indomethacin may improve the recovery of a person with traumatic brain injury. Objectives To assess the effects of indomethacin for adults with severe traumatic brain injury. Search methods We ran the searches from inception to 23 August 2019. We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2019, Issue 8) in the Cochrane Library, Ovid MEDLINE, Ovid Embase, CINAHL Plus (EBSCO), four other databases, and clinical trials registries. We also screened reference lists and conference abstracts, and contacted experts in the field. Selection criteria Our search criteria included randomised controlled trials (RCTs) that compared indomethacin with any control in adults presenting with severe traumatic brain injury associated with elevated intracranial pressure, with no previous decompressive surgery. Data collection and analysis Two review authors independently decided on the selection of the studies. We followed standard Cochrane methods. Main results We identified no eligible studies for this review, either completed or ongoing. Authors' conclusions We found no studies, either completed or ongoing, that assessed the effects of indomethacin in controlling intracranial hypertension secondary to severe traumatic brain injury. Thus, we cannot draw any conclusions about the effects of indomethacin on intracranial pressure, mortality rates, quality of life, disability or adverse effects. This absence of evidence should not be interpreted as evidence of no effect for indomethacin in controlling intracranial hypertension secondary to severe traumatic brain injury. It means that we have not identified eligible research for this review.20192019-01-0120192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articlehttp://hdl.handle.net/10641/1798reponame:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoriainstname:Universidad Francisco de VitoriaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:ddfv.ufv.es:10641/17982026-06-11T12:44:57Z
dc.title.none.fl_str_mv Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults.
title Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults.
spellingShingle Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults.
Martín Saborido, Carlos
title_short Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults.
title_full Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults.
title_fullStr Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults.
title_full_unstemmed Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults.
title_sort Indomethacin for intracranial hypertension secondary to severe traumatic brain injury in adults.
dc.creator.none.fl_str_mv Martín Saborido, Carlos
López Alcalde, Jesús
Ciapponi, Agustín
Sánchez Martín, Carlos Enrique
Garcia Garcia, Elena
Escobar Aguilar, Gema
Palermo, Maria Carolina
Baccaro, Fernando G
author Martín Saborido, Carlos
author_facet Martín Saborido, Carlos
López Alcalde, Jesús
Ciapponi, Agustín
Sánchez Martín, Carlos Enrique
Garcia Garcia, Elena
Escobar Aguilar, Gema
Palermo, Maria Carolina
Baccaro, Fernando G
author_role author
author2 López Alcalde, Jesús
Ciapponi, Agustín
Sánchez Martín, Carlos Enrique
Garcia Garcia, Elena
Escobar Aguilar, Gema
Palermo, Maria Carolina
Baccaro, Fernando G
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
description Background Among people who have suffered a traumatic brain injury, increased intracranial pressure continues to be a major cause of early death; it is estimated that about 11 people per 100 with traumatic brain injury die. Indomethacin (also known as indometacin) is a powerful cerebral vasoconstrictor that can reduce intracranial pressure and, ultimately, restore cerebral perfusion and oxygenation. Thus, indomethacin may improve the recovery of a person with traumatic brain injury. Objectives To assess the effects of indomethacin for adults with severe traumatic brain injury. Search methods We ran the searches from inception to 23 August 2019. We searched the Cochrane Central Register of Controlled Trials (CENTRAL; 2019, Issue 8) in the Cochrane Library, Ovid MEDLINE, Ovid Embase, CINAHL Plus (EBSCO), four other databases, and clinical trials registries. We also screened reference lists and conference abstracts, and contacted experts in the field. Selection criteria Our search criteria included randomised controlled trials (RCTs) that compared indomethacin with any control in adults presenting with severe traumatic brain injury associated with elevated intracranial pressure, with no previous decompressive surgery. Data collection and analysis Two review authors independently decided on the selection of the studies. We followed standard Cochrane methods. Main results We identified no eligible studies for this review, either completed or ongoing. Authors' conclusions We found no studies, either completed or ongoing, that assessed the effects of indomethacin in controlling intracranial hypertension secondary to severe traumatic brain injury. Thus, we cannot draw any conclusions about the effects of indomethacin on intracranial pressure, mortality rates, quality of life, disability or adverse effects. This absence of evidence should not be interpreted as evidence of no effect for indomethacin in controlling intracranial hypertension secondary to severe traumatic brain injury. It means that we have not identified eligible research for this review.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10641/1798
url http://hdl.handle.net/10641/1798
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname:Universidad Francisco de Vitoria
instname_str Universidad Francisco de Vitoria
reponame_str DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
collection DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
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