Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.

The aim of the present study was to map and grade evidence for the relationships between telomere length with a diverse range of health outcomes, using an umbrella review of systematic reviews with meta-analyses. We searched for meta-analyses of observational studies reporting on the association of...

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Autores: Smith L, Luchini C, Demurtas J, Soysal P, Stubbs B, Hamer M, Nottegar A, Lawlor RT, Lopez-Sanchez GF, Firth J, Koyanagi A, Roberts J, Willeit P, Waldhoer T, Loosemore M, Abbs AD, Johnstone J, Yang L, Veronese N
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p15879
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15879
Access Level:acceso abierto
Palabra clave:*Observational studies
*Telomere length
*Umbrella review
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spelling Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.Smith LLuchini CDemurtas JSoysal PStubbs BHamer MNottegar ALawlor RTLopez-Sanchez GFFirth JKoyanagi ARoberts JWilleit PWaldhoer TLoosemore MAbbs ADJohnstone JYang LVeronese N*Observational studies*Telomere length*Umbrella reviewThe aim of the present study was to map and grade evidence for the relationships between telomere length with a diverse range of health outcomes, using an umbrella review of systematic reviews with meta-analyses. We searched for meta-analyses of observational studies reporting on the association of telomere length with any health outcome (clinical disease outcomes and intermediate traits). For each association, random-effects summary effect size, 95% confidence interval (CI), and 95% prediction interval were calculated. To evaluate the credibility of the identified evidence, we assessed also heterogeneity, evidence for small-study effect and evidence for excess significance bias. Twenty-one relevant meta-analyses were identified reporting on 50 different outcomes. The level of evidence was high only for the association of short telomeres with higher risk of gastric cancer in the general population (relative risk, RR = 1.95, 95%CI: 1.68-2.26), and moderate for the association of shorter telomeres with diabetes or with Alzheimer's disease, even if limited to meta-analyses of case-control studies. There was weak evidence for twenty outcomes and not significant association for 27 health outcomes. The present umbrella review demonstrates that shorter telomere length may have an important role in incidence gastric cancer and, probably, diabetes and Alzheimer's disease. At the same time, conversely to general assumptions, it does not find strong evidence supporting the notion that shorter telomere length plays an important role in many health outcomes that have been studied thus far.ELSEVIER IRELAND LTD2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15879AGEING RESEARCH REVIEWSISSN: 15681637ISSNe: 18729649reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p158792026-05-27T12:37:41Z
dc.title.none.fl_str_mv Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.
title Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.
spellingShingle Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.
Smith L
*Observational studies
*Telomere length
*Umbrella review
title_short Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.
title_full Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.
title_fullStr Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.
title_full_unstemmed Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.
title_sort Telomere length and health outcomes: An umbrella review of systematic reviews and meta-analyses of observational studies.
dc.creator.none.fl_str_mv Smith L
Luchini C
Demurtas J
Soysal P
Stubbs B
Hamer M
Nottegar A
Lawlor RT
Lopez-Sanchez GF
Firth J
Koyanagi A
Roberts J
Willeit P
Waldhoer T
Loosemore M
Abbs AD
Johnstone J
Yang L
Veronese N
author Smith L
author_facet Smith L
Luchini C
Demurtas J
Soysal P
Stubbs B
Hamer M
Nottegar A
Lawlor RT
Lopez-Sanchez GF
Firth J
Koyanagi A
Roberts J
Willeit P
Waldhoer T
Loosemore M
Abbs AD
Johnstone J
Yang L
Veronese N
author_role author
author2 Luchini C
Demurtas J
Soysal P
Stubbs B
Hamer M
Nottegar A
Lawlor RT
Lopez-Sanchez GF
Firth J
Koyanagi A
Roberts J
Willeit P
Waldhoer T
Loosemore M
Abbs AD
Johnstone J
Yang L
Veronese N
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv *Observational studies
*Telomere length
*Umbrella review
topic *Observational studies
*Telomere length
*Umbrella review
description The aim of the present study was to map and grade evidence for the relationships between telomere length with a diverse range of health outcomes, using an umbrella review of systematic reviews with meta-analyses. We searched for meta-analyses of observational studies reporting on the association of telomere length with any health outcome (clinical disease outcomes and intermediate traits). For each association, random-effects summary effect size, 95% confidence interval (CI), and 95% prediction interval were calculated. To evaluate the credibility of the identified evidence, we assessed also heterogeneity, evidence for small-study effect and evidence for excess significance bias. Twenty-one relevant meta-analyses were identified reporting on 50 different outcomes. The level of evidence was high only for the association of short telomeres with higher risk of gastric cancer in the general population (relative risk, RR = 1.95, 95%CI: 1.68-2.26), and moderate for the association of shorter telomeres with diabetes or with Alzheimer's disease, even if limited to meta-analyses of case-control studies. There was weak evidence for twenty outcomes and not significant association for 27 health outcomes. The present umbrella review demonstrates that shorter telomere length may have an important role in incidence gastric cancer and, probably, diabetes and Alzheimer's disease. At the same time, conversely to general assumptions, it does not find strong evidence supporting the notion that shorter telomere length plays an important role in many health outcomes that have been studied thus far.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15879
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15879
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER IRELAND LTD
publisher.none.fl_str_mv ELSEVIER IRELAND LTD
dc.source.none.fl_str_mv AGEING RESEARCH REVIEWS
ISSN: 15681637
ISSNe: 18729649
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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