Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery

A gelatin-based hydrogel was infiltrated and degraded-released in two different titanium foams with porosities of 30 and 60 vol.% (Ti30 and Ti60 foams) and fabricated by the space holder technique to evaluate its potential to act as an innovative, alternative, and localised method to introduce both...

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Autores: Mehdi-Sefiani, Hanaa, Pérez-Puyana, Víctor, Ostos, Francisco José, Sepúlveda, Ranier, Romero Palacios, Alberto, Rafii-El-Idrissi Benhnia, Mohamed, Chicardi, E.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/340112
Acceso en línea:http://hdl.handle.net/10261/340112
https://api.elsevier.com/content/abstract/scopus_id/85146559730
Access Level:acceso abierto
Palabra clave:Degradation rate
Gelatin
Hydrogel
Infiltration
Porous titanium
Solid foams
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spelling Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug DeliveryMehdi-Sefiani, HanaaPérez-Puyana, VíctorOstos, Francisco JoséSepúlveda, RanierRomero Palacios, AlbertoRafii-El-Idrissi Benhnia, MohamedChicardi, E.Degradation rateGelatinHydrogelInfiltrationPorous titaniumSolid foamsA gelatin-based hydrogel was infiltrated and degraded-released in two different titanium foams with porosities of 30 and 60 vol.% (Ti30 and Ti60 foams) and fabricated by the space holder technique to evaluate its potential to act as an innovative, alternative, and localised method to introduce both active pharmaceutical ingredients, such as antibiotics and non-steroidal anti-inflammatory drugs, and growth factors, such as morphogens, required after bone-tissue replacement surgeries. In addition, the kinetic behaviour was studied for both infiltration and degradation-release processes. A higher infiltration rate was observed in the Ti60 foam. The maximum infiltration hydrogel was achieved for the Ti30 and Ti60 foams after 120 min and 75 min, respectively. Further, both processes followed a Lucas-Washburn theoretical behaviour, typical for the infiltration of a fluid by capillarity in porous channels. Regarding the subsequent degradation-release process, both systems showed similar exponential degradation performance, with the full release from Ti60 foam (80 min), versus 45 min for Ti30, due to the greater interconnected porosity open to the surface of the Ti60 foam in comparison with the Ti30 foam. In addition, the optimal biocompatibility of the hydrogel was confirmed, with the total absence of cytotoxicity and the promotion of cell growth in the fibroblast cells evaluated.The characterization studies were financed by University of Seville under project No. 2021/00000691 by the VI Research Program of the University of Seville.Peer reviewedMultidisciplinary Digital Publishing InstituteUniversidad de SevillaMehdi-Sefiani, Hanaa [0000-0001-9409-7197]Pérez-Puyana, Víctor [0000-0001-5309-9647]Ostos, Francisco José [0000-0001-6583-6974]Sepúlveda, Ranier [0000-0002-7195-8131]Romero Palacios, Alberto [0000-0002-6323-9938]Chicardi, E. [0000-0002-6481-0438]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/340112https://api.elsevier.com/content/abstract/scopus_id/85146559730reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.3390/polym15020275Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3401122026-05-22T06:33:51Z
dc.title.none.fl_str_mv Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery
title Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery
spellingShingle Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery
Mehdi-Sefiani, Hanaa
Degradation rate
Gelatin
Hydrogel
Infiltration
Porous titanium
Solid foams
title_short Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery
title_full Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery
title_fullStr Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery
title_full_unstemmed Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery
title_sort Type-A Gelatin-Based Hydrogel Infiltration and Degradation in Titanium Foams as a Potential Method for Localised Drug Delivery
dc.creator.none.fl_str_mv Mehdi-Sefiani, Hanaa
Pérez-Puyana, Víctor
Ostos, Francisco José
Sepúlveda, Ranier
Romero Palacios, Alberto
Rafii-El-Idrissi Benhnia, Mohamed
Chicardi, E.
author Mehdi-Sefiani, Hanaa
author_facet Mehdi-Sefiani, Hanaa
Pérez-Puyana, Víctor
Ostos, Francisco José
Sepúlveda, Ranier
Romero Palacios, Alberto
Rafii-El-Idrissi Benhnia, Mohamed
Chicardi, E.
author_role author
author2 Pérez-Puyana, Víctor
Ostos, Francisco José
Sepúlveda, Ranier
Romero Palacios, Alberto
Rafii-El-Idrissi Benhnia, Mohamed
Chicardi, E.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Sevilla
Mehdi-Sefiani, Hanaa [0000-0001-9409-7197]
Pérez-Puyana, Víctor [0000-0001-5309-9647]
Ostos, Francisco José [0000-0001-6583-6974]
Sepúlveda, Ranier [0000-0002-7195-8131]
Romero Palacios, Alberto [0000-0002-6323-9938]
Chicardi, E. [0000-0002-6481-0438]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Degradation rate
Gelatin
Hydrogel
Infiltration
Porous titanium
Solid foams
topic Degradation rate
Gelatin
Hydrogel
Infiltration
Porous titanium
Solid foams
description A gelatin-based hydrogel was infiltrated and degraded-released in two different titanium foams with porosities of 30 and 60 vol.% (Ti30 and Ti60 foams) and fabricated by the space holder technique to evaluate its potential to act as an innovative, alternative, and localised method to introduce both active pharmaceutical ingredients, such as antibiotics and non-steroidal anti-inflammatory drugs, and growth factors, such as morphogens, required after bone-tissue replacement surgeries. In addition, the kinetic behaviour was studied for both infiltration and degradation-release processes. A higher infiltration rate was observed in the Ti60 foam. The maximum infiltration hydrogel was achieved for the Ti30 and Ti60 foams after 120 min and 75 min, respectively. Further, both processes followed a Lucas-Washburn theoretical behaviour, typical for the infiltration of a fluid by capillarity in porous channels. Regarding the subsequent degradation-release process, both systems showed similar exponential degradation performance, with the full release from Ti60 foam (80 min), versus 45 min for Ti30, due to the greater interconnected porosity open to the surface of the Ti60 foam in comparison with the Ti30 foam. In addition, the optimal biocompatibility of the hydrogel was confirmed, with the total absence of cytotoxicity and the promotion of cell growth in the fibroblast cells evaluated.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/340112
https://api.elsevier.com/content/abstract/scopus_id/85146559730
url http://hdl.handle.net/10261/340112
https://api.elsevier.com/content/abstract/scopus_id/85146559730
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.3390/polym15020275
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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