A Mediterranean Diet-Based Metabolomic Score and Cognitive Decline in Older Adults: A Case–Control Analysis Nested within the Three-City Cohort Study

Scope Evidence on the Mediterranean diet (MD) and age-related cognitive decline (CD) is still inconclusive partly due to self-reported dietary assessment. The aim of the current study is to develop an MD- metabolomic score (MDMS) and investigate its association with CD in community-dwelling older ad...

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Detalhes bibliográficos
Autores: Tor Roca, Alba, Sànchez, Àlex (Sànchez Pla), Korosi, Aniko, Pallàs i Llibería, Mercè, 1964-, Lucassen, Paul J., Castellano Escuder, Pol, Aigner, Ludwig, González-Domínguez, Raúl, Manach, Claudine, Carmona Pontaque, Francesc, Vegas, Esteban, Helmer, Catherine, Feart, Catherine, Lefèvre Arbogast, Sophie, Neuffer, Jeanne, Lee, Hyunah, Thuret, Sandrine, Andrés Lacueva, Ma. Cristina, Samieri, Cécilia, Urpí Sardà, Mireia
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/219767
Acesso em linha:https://hdl.handle.net/2445/219767
Access Level:acceso abierto
Palavra-chave:Envelliment
Cuina mediterrània
Aging
Mediterranean cooking
Descrição
Resumo:Scope Evidence on the Mediterranean diet (MD) and age-related cognitive decline (CD) is still inconclusive partly due to self-reported dietary assessment. The aim of the current study is to develop an MD- metabolomic score (MDMS) and investigate its association with CD in community-dwelling older adults. Methods and results This study includes participants from the Three-City Study from the Bordeaux (n = 418) and Dijon (n = 422) cohorts who are free of dementia at baseline. Repeated measures of cognition over 12 years are collected. An MDMS is designed based on serum biomarkers related to MD key food groups and using a targeted metabolomics platform. Associations with CD are investigated through conditional logistic regression (matched on age, sex, and education level) in both sample sets. The MDMS is found to be inversely associated with CD (odds ratio [OR] [95% confidence interval (CI)] = 0.90 [0.80–1.00]; p = 0.048) in the Bordeaux (discovery) cohort. Results are comparable in the Dijon (validation) cohort, with a trend toward significance (OR [95% CI] = 0.91 [0.83–1.01]; p = 0.084). Conclusions A greater adherence to the MD, here assessed by a serum MDMS, is associated with lower odds of CD in older adults.

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