A genome-wide association analysis for body, udder, and leg conformation traits recorded in Murciano-Granadina goats

Morphological traits are of great importance to dairy goat production given their effect on phenotypes of economic interest. However, their underlying genomic architecture has not yet been extensively characterized. Herein, we aimed to identify genomic regions associated with body, udder, and leg co...

Descripción completa

Detalles Bibliográficos
Autores: Luigi Sierra, Maria Gracia|||0000-0002-6414-0550, Landi, Vincenzo|||0000-0003-1385-8439, Guan, Dailu|||0000-0001-8800-3158, Delgado Bermejo, Juan Vicente|||0000-0003-1657-8838, Castelló Farré, Anna|||0000-0001-8497-6251, Cabrera Pane, Betlem|||0000-0003-2702-5374, Mármol-Sánchez, Emilio|||0000-0002-4393-1740, Fernández Álvarez, Javier|||0000-0003-0450-5869, Gómez-Carpio, Mayra, Martinez, Amparo|||0000-0002-6944-0501, Such i Martí, Francesc Xavier|||0000-0002-9712-4477, Jordana i Vidal, Jordi|||0000-0002-7789-2989, Amills i Eras, Marcel|||0000-0002-8999-0770
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:238716
Acceso en línea:https://ddd.uab.cat/record/238716
https://dx.doi.org/urn:doi:10.3168/jds.2020-18461
Access Level:acceso abierto
Palabra clave:Genome-wide association study (GWAS)
Goat
Murciano-Granadina
Morphological trait
Descripción
Sumario:Morphological traits are of great importance to dairy goat production given their effect on phenotypes of economic interest. However, their underlying genomic architecture has not yet been extensively characterized. Herein, we aimed to identify genomic regions associated with body, udder, and leg conformation traits recorded in 825 Murciano-Granadina goats. We genotyped this resource population using the GoatSNP50 BeadChip (Illumina Inc., San Diego, CA) and performed genome-wide association analyses using the GEMMA software. We found 2 genome-wide significant associations between markers rs268273468 [Capra hircus (CHI) 16:69617700] and rs268249346 (CHI 28:18321523) and medial suspensory ligament. In contrast, we did not detect any genome-wide significant associations for body and leg traits. Moreover, we found 12, 19, and 7 chromosome-wide significant associations for udder, body, and leg traits, respectively. Comparison of our data with previous studies revealed a low level of positional concordance between regions associated with morphological traits. In addition to technical factors, this lack of concordance could be due to a substantial level of genetic heterogeneity among breeds or to the strong polygenic background of morphological traits, which makes it difficult to detect genetic factors that have small phenotypic effects.

Similares en LA Referencia