MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction.

To compare the expression of microRNA-185-5p (miR-185-5p) in normal foetuses and in foetuses with late-onset growth restriction (FGR) and to determine the factors influencing this expression. In a prospective study, 40 foetuses (22 of them with late-onset FGR and 18 with normal growth) were scanned...

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Detalles Bibliográficos
Autores: Morales-Rosello, J, Loscalzo, G, Garcia-Lopez, EM, Cabellos, JSI, Garcia-Gimenez, JL, Martinez, AJC, Marin, AP
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p16378
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/16378
Access Level:acceso abierto
Palabra clave:MicroRNA-185-5p
foetal Doppler
foetal growth
late-onset foetal growth restriction
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spelling MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction.Morales-Rosello, JLoscalzo, GGarcia-Lopez, EMCabellos, JSIGarcia-Gimenez, JLMartinez, AJCMarin, APMicroRNA-185-5pfoetal Dopplerfoetal growthlate-onset foetal growth restrictionTo compare the expression of microRNA-185-5p (miR-185-5p) in normal foetuses and in foetuses with late-onset growth restriction (FGR) and to determine the factors influencing this expression. In a prospective study, 40 foetuses (22 of them with late-onset FGR and 18 with normal growth) were scanned with Doppler ultrasound after week 35 and followed until birth. Subsequently, blood samples from umbilical cords were collected after delivery to evaluate the expression of miR-185-5p using real-time qPCR. Finally, multivariable regression analysis was applied to determine the clinical and ultrasonographic factors influencing miR-185-5p expression in both normal and late-onset FGR foetuses. In comparison with normal foetuses, late-onset FGR foetuses expressed upregulation of miR-185-5p (2.26 ± 1.30 versus 1.27 ± 1.03 2^-ddCt, P = 0.011). Multivariable regression analysis confirmed that cerebroplacental ratio (P < 0.05) was the only determinant of this overexpression. FGR foetuses overexpress miR-185-5p in relation to brain-sparing. Future studies will be needed to investigate the role of miR-185 in the management of late-onset FGR.TAYLOR & FRANCIS INC2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/16378EpigeneticsISSN: 15592294ISSNe: 15592308reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p163782026-06-07T16:35:31Z
dc.title.none.fl_str_mv MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction.
title MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction.
spellingShingle MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction.
Morales-Rosello, J
MicroRNA-185-5p
foetal Doppler
foetal growth
late-onset foetal growth restriction
title_short MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction.
title_full MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction.
title_fullStr MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction.
title_full_unstemmed MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction.
title_sort MicroRNA-185-5p: a marker of brain-sparing in foetuses with late-onset growth restriction.
dc.creator.none.fl_str_mv Morales-Rosello, J
Loscalzo, G
Garcia-Lopez, EM
Cabellos, JSI
Garcia-Gimenez, JL
Martinez, AJC
Marin, AP
author Morales-Rosello, J
author_facet Morales-Rosello, J
Loscalzo, G
Garcia-Lopez, EM
Cabellos, JSI
Garcia-Gimenez, JL
Martinez, AJC
Marin, AP
author_role author
author2 Loscalzo, G
Garcia-Lopez, EM
Cabellos, JSI
Garcia-Gimenez, JL
Martinez, AJC
Marin, AP
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv MicroRNA-185-5p
foetal Doppler
foetal growth
late-onset foetal growth restriction
topic MicroRNA-185-5p
foetal Doppler
foetal growth
late-onset foetal growth restriction
description To compare the expression of microRNA-185-5p (miR-185-5p) in normal foetuses and in foetuses with late-onset growth restriction (FGR) and to determine the factors influencing this expression. In a prospective study, 40 foetuses (22 of them with late-onset FGR and 18 with normal growth) were scanned with Doppler ultrasound after week 35 and followed until birth. Subsequently, blood samples from umbilical cords were collected after delivery to evaluate the expression of miR-185-5p using real-time qPCR. Finally, multivariable regression analysis was applied to determine the clinical and ultrasonographic factors influencing miR-185-5p expression in both normal and late-onset FGR foetuses. In comparison with normal foetuses, late-onset FGR foetuses expressed upregulation of miR-185-5p (2.26 ± 1.30 versus 1.27 ± 1.03 2^-ddCt, P = 0.011). Multivariable regression analysis confirmed that cerebroplacental ratio (P < 0.05) was the only determinant of this overexpression. FGR foetuses overexpress miR-185-5p in relation to brain-sparing. Future studies will be needed to investigate the role of miR-185 in the management of late-onset FGR.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/16378
url https://incliva.portalinvestigacion.com/publicaciones/16378
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv TAYLOR & FRANCIS INC
publisher.none.fl_str_mv TAYLOR & FRANCIS INC
dc.source.none.fl_str_mv Epigenetics
ISSN: 15592294
ISSNe: 15592308
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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