Foveal remodeling of retinal microvasculature in Parkinson’s disease
[EN] Background: Retinal microvascular alterations have been previously described in Parkinson’s disease (PD) patients using optical coherence tomography angiography (OCT-A). However, an extensive description of retinal vascular morphological features, their association with PD-related clinical vari...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad del País Vasco |
| Repositorio: | Addi. Archivo Digital para la Docencia y la Investigación |
| OAI Identifier: | oai:addi.ehu.eus:10810/52689 |
| Acceso en línea: | http://hdl.handle.net/10810/52689 |
| Access Level: | acceso abierto |
| Palabra clave: | neurodegeneration angiography capillary density Parkinson’s disease retina optical coherence tomography biomarker |
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Foveal remodeling of retinal microvasculature in Parkinson’s disease |
| title |
Foveal remodeling of retinal microvasculature in Parkinson’s disease |
| spellingShingle |
Foveal remodeling of retinal microvasculature in Parkinson’s disease Murueta-Goyena Larrañaga, Ane neurodegeneration angiography capillary density Parkinson’s disease retina optical coherence tomography biomarker |
| title_short |
Foveal remodeling of retinal microvasculature in Parkinson’s disease |
| title_full |
Foveal remodeling of retinal microvasculature in Parkinson’s disease |
| title_fullStr |
Foveal remodeling of retinal microvasculature in Parkinson’s disease |
| title_full_unstemmed |
Foveal remodeling of retinal microvasculature in Parkinson’s disease |
| title_sort |
Foveal remodeling of retinal microvasculature in Parkinson’s disease |
| dc.creator.none.fl_str_mv |
Murueta-Goyena Larrañaga, Ane Barrenechea, Maitane Erramuzpe Aliaga, Asier Teijeira Portas, Sara Pengo, Marta Ayala Fernández, Unai Romero Bascones, David Acera, Marian Del Pino Sáez, Rocío Gómez Esteban, Juan Carlos Gabilondo Cuellar, Iñigo |
| author |
Murueta-Goyena Larrañaga, Ane |
| author_facet |
Murueta-Goyena Larrañaga, Ane Barrenechea, Maitane Erramuzpe Aliaga, Asier Teijeira Portas, Sara Pengo, Marta Ayala Fernández, Unai Romero Bascones, David Acera, Marian Del Pino Sáez, Rocío Gómez Esteban, Juan Carlos Gabilondo Cuellar, Iñigo |
| author_role |
author |
| author2 |
Barrenechea, Maitane Erramuzpe Aliaga, Asier Teijeira Portas, Sara Pengo, Marta Ayala Fernández, Unai Romero Bascones, David Acera, Marian Del Pino Sáez, Rocío Gómez Esteban, Juan Carlos Gabilondo Cuellar, Iñigo |
| author2_role |
author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
neurodegeneration angiography capillary density Parkinson’s disease retina optical coherence tomography biomarker |
| topic |
neurodegeneration angiography capillary density Parkinson’s disease retina optical coherence tomography biomarker |
| description |
[EN] Background: Retinal microvascular alterations have been previously described in Parkinson’s disease (PD) patients using optical coherence tomography angiography (OCT-A). However, an extensive description of retinal vascular morphological features, their association with PD-related clinical variables and their potential use as diagnostic biomarkers has not been explored. Methods: We performed a cross-sectional study including 49 PD patients (87 eyes) and 40 controls (73 eyes). Retinal microvasculature was evaluated with Spectralis OCT-A and cognitive status with Montreal Cognitive Assessment. Unified PD Rating Scale and disease duration were recorded in patients. We extracted microvascular parameters from superficial and deep vascular plexuses of the macula, including the area and circularity of foveal avascular zone (FAZ), skeleton density, perfusion density, vessel perimeter index, vessel mean diameter, fractal dimension (FD) and lacunarity using Python and MATLAB. We compared the microvascular parameters between groups and explored their association with thickness of macular layers and clinical outcomes. Data were analyzed with General Estimating Equations (GEE) and adjusted for age, sex, and hypertension. Logistic regression GEE models were fitted to predict diagnosis of PD versus controls from microvascular, demographic, and clinical data. The discrimination ability of models was tested with receiver operating characteristic curves. Results: FAZ area was significantly smaller in patients compared to controls in superficial and deep plexuses, whereas perfusion density, skeleton density, FD and lacunarity of capillaries were increased in the foveal zone of PD. In the parafovea, microvascular parameters of superficial plexus were associated with ganglion cellinner plexiform layer thickness, but this was mainly driven by PD with mild cognitive impairment. No such associations were observed in controls. FAZ area was negatively associated with cognition in PD (non-adjusted models). Foveal lacunarity, combined with demographic and clinical confounding factors, yielded an outstanding diagnostic accuracy for discriminating PD patients from controls. Conclusion: Parkinson’s disease patients displayed foveal microvascular alterations causing an enlargement of the vascular bed surrounding FAZ. Parafoveal microvascular alterations were less pronounced but were related to inner retinal layer thinning. Retinal microvascular abnormalities helped discriminating PD from controls. All this supports OCT-A as a potential non-invasive biomarker to reveal vascular pathophysiology and improve diagnostic accuracy in PD. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021 2021 |
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info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10810/52689 |
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http://hdl.handle.net/10810/52689 |
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Inglés |
| language_invalid_str_mv |
Inglés |
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https://www.frontiersin.org/articles/10.3389/fnins.2021.708700 |
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info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/3.0/es/ Atribución 3.0 España |
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openAccess |
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http://creativecommons.org/licenses/by/3.0/es/ Atribución 3.0 España |
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application/pdf |
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Frontiers Media |
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Frontiers Media |
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reponame:Addi. Archivo Digital para la Docencia y la Investigación instname:Universidad del País Vasco |
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Universidad del País Vasco |
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Addi. Archivo Digital para la Docencia y la Investigación |
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Addi. Archivo Digital para la Docencia y la Investigación |
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1869409166714470400 |
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Foveal remodeling of retinal microvasculature in Parkinson’s diseaseMurueta-Goyena Larrañaga, AneBarrenechea, MaitaneErramuzpe Aliaga, AsierTeijeira Portas, SaraPengo, MartaAyala Fernández, UnaiRomero Bascones, DavidAcera, MarianDel Pino Sáez, RocíoGómez Esteban, Juan CarlosGabilondo Cuellar, IñigoneurodegenerationangiographycapillarydensityParkinson’s diseaseretinaoptical coherence tomographybiomarker[EN] Background: Retinal microvascular alterations have been previously described in Parkinson’s disease (PD) patients using optical coherence tomography angiography (OCT-A). However, an extensive description of retinal vascular morphological features, their association with PD-related clinical variables and their potential use as diagnostic biomarkers has not been explored. Methods: We performed a cross-sectional study including 49 PD patients (87 eyes) and 40 controls (73 eyes). Retinal microvasculature was evaluated with Spectralis OCT-A and cognitive status with Montreal Cognitive Assessment. Unified PD Rating Scale and disease duration were recorded in patients. We extracted microvascular parameters from superficial and deep vascular plexuses of the macula, including the area and circularity of foveal avascular zone (FAZ), skeleton density, perfusion density, vessel perimeter index, vessel mean diameter, fractal dimension (FD) and lacunarity using Python and MATLAB. We compared the microvascular parameters between groups and explored their association with thickness of macular layers and clinical outcomes. Data were analyzed with General Estimating Equations (GEE) and adjusted for age, sex, and hypertension. Logistic regression GEE models were fitted to predict diagnosis of PD versus controls from microvascular, demographic, and clinical data. The discrimination ability of models was tested with receiver operating characteristic curves. Results: FAZ area was significantly smaller in patients compared to controls in superficial and deep plexuses, whereas perfusion density, skeleton density, FD and lacunarity of capillaries were increased in the foveal zone of PD. In the parafovea, microvascular parameters of superficial plexus were associated with ganglion cellinner plexiform layer thickness, but this was mainly driven by PD with mild cognitive impairment. No such associations were observed in controls. FAZ area was negatively associated with cognition in PD (non-adjusted models). Foveal lacunarity, combined with demographic and clinical confounding factors, yielded an outstanding diagnostic accuracy for discriminating PD patients from controls. Conclusion: Parkinson’s disease patients displayed foveal microvascular alterations causing an enlargement of the vascular bed surrounding FAZ. Parafoveal microvascular alterations were less pronounced but were related to inner retinal layer thinning. Retinal microvascular abnormalities helped discriminating PD from controls. All this supports OCT-A as a potential non-invasive biomarker to reveal vascular pathophysiology and improve diagnostic accuracy in PD.This study was partially co-funded by the Instituto de Salud Carlos III through the projects PI14/00679 and PI16/00005 (co-funded by European Regional Development Fund/European Social Fund “A way to make Europe”/“Investing in your future”), and by the Department of Health of the Basque Government through the projects “2019111100” and “2020333033”.Frontiers Media202120212021info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/52689reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.frontiersin.org/articles/10.3389/fnins.2021.708700info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/© 2021 Murueta-Goyena, Barrenechea, Erramuzpe, Teijeira-Portas, Pengo, Ayala, Romero-Bascones, Acera, Del Pino, Gómez-Esteban and Gabilondo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Atribución 3.0 Españaoai:addi.ehu.eus:10810/526892026-06-18T09:23:17Z |
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