Integratomic investigation to assess the liver lipidomic and antiinflammatory activity of lupin protein hydrolysate

Chronic inflammation plays a significant role in the development and progression of metabolic dysfunction-related diseases. This study investigating a protein hydrolysate from Lupinus angustifolius (LPH) in mice model on a western diet (WD) aimed to elucidate its potential beneficial role in improvi...

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Detalles Bibliográficos
Autores: Casati, Sara, Dei Cas, Michele, d'Adduzio, Lorenza, Cruz Chamorro, Iván, Santos Sánchez, Guillermo, Bollati, Carlotta, Fanzaga, Melissa, Pedroche, Justo, Millán Linares, María del Carmen, Roda, Gabriella, Carrillo Vico, Antonio, Lammi, Carmen
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/182544
Acceso en línea:https://hdl.handle.net/11441/182544
https://doi.org/10.1038/s41538-025-00515-7
Access Level:acceso abierto
Palabra clave:Lupin protein hydrolysate
Liver lipidomics
Anti-inflammatory activity
Metabolic-associated fatty liver disease (MAFLD)
Bioactive peptides
Functional foods
Descripción
Sumario:Chronic inflammation plays a significant role in the development and progression of metabolic dysfunction-related diseases. This study investigating a protein hydrolysate from Lupinus angustifolius (LPH) in mice model on a western diet (WD) aimed to elucidate its potential beneficial role in improving the lipidomic and anti-inflammatory profile. To achieve this objective, a lipidomic approach in combination with the evaluation of protein level modulation of selected key enzymes that are pivotal involved in the bioactive lipid pathway synthesis/regulation was performed on liver homogenates. Specifically, LPH positively impacted DHCer, SM, LacCer, Sph 1, DHSph 1, and S1P 1 concentrations, and restored the basal conditions of ASAH1 and ASM, proteins involved in sphingolipid metabolism. LPH also reduced the FASN and PPARγ levels and eicosanoids, with positive modulation of the COX-2 and ALOX5. Additionally, LPH reduced the WB-induced AEA and 2AG concentrations.

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