Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning

Objectives Real-world data regarding rheumatoid arthritis (RA) and its association with interstitial lung disease (ILD) is still scarce. This study aimed to estimate the prevalence of RA and ILD in patients with RA (RAILD) in Spain, and to compare clinical characteristics of patients with RA with an...

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Autores: Román Ivorra, José Andrés, Trallero-Araguas, Ernesto, López Lasanta, Maria, Cebrián, Laura, Lojo, Leticia, López-Muñíz, Belén, Fernández-Melon, Julia, Núñez, Belén, Silva-Fernández, Lucia, Veiga Cabello, Raúl, Ahijado, Pilar, De la Morena Barrio, Isabel, Costas Torrijo, Nerea, Safont, Belén, Ornilla, Enrique, Restrepo, Juliana, Campo, Arantxa, Andreu, JosÉ L., Díez, Elvira, López Robles, Alejandra, Bollo, Elena, Benavent, Diego, Vilanova, David, Luján Valdés, Sara, Castellanos-Moreira, Raul
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Católica de Valencia San Vicente Mártir
Repositorio:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Idioma:inglés
OAI Identifier:oai:riucv.ucv.es:20.500.12466/5118
Acceso en línea:http://hdl.handle.net/20.500.12466/5118
Access Level:acceso abierto
Palabra clave:3205.09 Reumatología
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spelling Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learningRomán Ivorra, José AndrésTrallero-Araguas, ErnestoLópez Lasanta, MariaCebrián, LauraLojo, LeticiaLópez-Muñíz, BelénFernández-Melon, JuliaNúñez, BelénSilva-Fernández, LuciaVeiga Cabello, RaúlAhijado, PilarDe la Morena Barrio, IsabelCostas Torrijo, NereaSafont, BelénOrnilla, EnriqueRestrepo, JulianaCampo, ArantxaAndreu, JosÉ L.Díez, ElviraLópez Robles, AlejandraBollo, ElenaBenavent, DiegoVilanova, DavidLuján Valdés, SaraCastellanos-Moreira, Raul3205.09 ReumatologíaObjectives Real-world data regarding rheumatoid arthritis (RA) and its association with interstitial lung disease (ILD) is still scarce. This study aimed to estimate the prevalence of RA and ILD in patients with RA (RAILD) in Spain, and to compare clinical characteristics of patients with RA with and without ILD using natural language processing (NLP) on electronic health records (EHR). Methods Observational case–control, retrospective and multicentre study based on the secondary use of unstructured clinical data from patients with adult RA and RAILD from nine hospitals between 2014 and 2019. NLP was used to extract unstructured clinical information from EHR and standardise it into a SNOMED-CT terminology. Prevalence of RA and RAILD were calculated, and a descriptive analysis was performed. Characteristics between patients with RAILD and RA patients without ILD (RAnonILD) were compared. Results From a source population of 3 176 165 patients and 64 241 683 EHRs, 13 958 patients with RA were identified. Of those, 5.1% patients additionally had ILD (RAILD). The overall age-adjusted prevalence of RA and RAILD were 0.53% and 0.02%, respectively. The most common ILD subtype was usual interstitial pneumonia (29.3%). When comparing RAILD versus RAnonILD patients, RAILD patients were older and had more comorbidities, notably concerning infections (33.6% vs 16.5%, p<0.001), malignancies (15.9% vs 8.5%, p<0.001) and cardiovascular disease (25.8% vs 13.9%, p<0.001) than RAnonILD. RAILD patients also had higher inflammatory burden reflected in more pharmacological prescriptions and higher inflammatory parameters and presented a higher in-hospital mortality with a higher risk of death (HR 2.32; 95%CI 1.59 to 2.81, p<0.001). Conclusions We found an estimated age-adjusted prevalence of RA and RAILD by analysing real-world data through NLP. RAILD patients were more vulnerable at the time of inclusion with higher comorbidity and inflammatory burden than RAnonILD, which correlated with higher mortality.20252025-01-1420242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12466/5118reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártirinstname:Universidad Católica de Valencia San Vicente MártirInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:riucv.ucv.es:20.500.12466/51182026-06-19T08:32:07Z
dc.title.none.fl_str_mv Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning
title Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning
spellingShingle Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning
Román Ivorra, José Andrés
3205.09 Reumatología
title_short Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning
title_full Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning
title_fullStr Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning
title_full_unstemmed Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning
title_sort Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning
dc.creator.none.fl_str_mv Román Ivorra, José Andrés
Trallero-Araguas, Ernesto
López Lasanta, Maria
Cebrián, Laura
Lojo, Leticia
López-Muñíz, Belén
Fernández-Melon, Julia
Núñez, Belén
Silva-Fernández, Lucia
Veiga Cabello, Raúl
Ahijado, Pilar
De la Morena Barrio, Isabel
Costas Torrijo, Nerea
Safont, Belén
Ornilla, Enrique
Restrepo, Juliana
Campo, Arantxa
Andreu, JosÉ L.
Díez, Elvira
López Robles, Alejandra
Bollo, Elena
Benavent, Diego
Vilanova, David
Luján Valdés, Sara
Castellanos-Moreira, Raul
author Román Ivorra, José Andrés
author_facet Román Ivorra, José Andrés
Trallero-Araguas, Ernesto
López Lasanta, Maria
Cebrián, Laura
Lojo, Leticia
López-Muñíz, Belén
Fernández-Melon, Julia
Núñez, Belén
Silva-Fernández, Lucia
Veiga Cabello, Raúl
Ahijado, Pilar
De la Morena Barrio, Isabel
Costas Torrijo, Nerea
Safont, Belén
Ornilla, Enrique
Restrepo, Juliana
Campo, Arantxa
Andreu, JosÉ L.
Díez, Elvira
López Robles, Alejandra
Bollo, Elena
Benavent, Diego
Vilanova, David
Luján Valdés, Sara
Castellanos-Moreira, Raul
author_role author
author2 Trallero-Araguas, Ernesto
López Lasanta, Maria
Cebrián, Laura
Lojo, Leticia
López-Muñíz, Belén
Fernández-Melon, Julia
Núñez, Belén
Silva-Fernández, Lucia
Veiga Cabello, Raúl
Ahijado, Pilar
De la Morena Barrio, Isabel
Costas Torrijo, Nerea
Safont, Belén
Ornilla, Enrique
Restrepo, Juliana
Campo, Arantxa
Andreu, JosÉ L.
Díez, Elvira
López Robles, Alejandra
Bollo, Elena
Benavent, Diego
Vilanova, David
Luján Valdés, Sara
Castellanos-Moreira, Raul
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv 3205.09 Reumatología
topic 3205.09 Reumatología
description Objectives Real-world data regarding rheumatoid arthritis (RA) and its association with interstitial lung disease (ILD) is still scarce. This study aimed to estimate the prevalence of RA and ILD in patients with RA (RAILD) in Spain, and to compare clinical characteristics of patients with RA with and without ILD using natural language processing (NLP) on electronic health records (EHR). Methods Observational case–control, retrospective and multicentre study based on the secondary use of unstructured clinical data from patients with adult RA and RAILD from nine hospitals between 2014 and 2019. NLP was used to extract unstructured clinical information from EHR and standardise it into a SNOMED-CT terminology. Prevalence of RA and RAILD were calculated, and a descriptive analysis was performed. Characteristics between patients with RAILD and RA patients without ILD (RAnonILD) were compared. Results From a source population of 3 176 165 patients and 64 241 683 EHRs, 13 958 patients with RA were identified. Of those, 5.1% patients additionally had ILD (RAILD). The overall age-adjusted prevalence of RA and RAILD were 0.53% and 0.02%, respectively. The most common ILD subtype was usual interstitial pneumonia (29.3%). When comparing RAILD versus RAnonILD patients, RAILD patients were older and had more comorbidities, notably concerning infections (33.6% vs 16.5%, p<0.001), malignancies (15.9% vs 8.5%, p<0.001) and cardiovascular disease (25.8% vs 13.9%, p<0.001) than RAnonILD. RAILD patients also had higher inflammatory burden reflected in more pharmacological prescriptions and higher inflammatory parameters and presented a higher in-hospital mortality with a higher risk of death (HR 2.32; 95%CI 1.59 to 2.81, p<0.001). Conclusions We found an estimated age-adjusted prevalence of RA and RAILD by analysing real-world data through NLP. RAILD patients were more vulnerable at the time of inclusion with higher comorbidity and inflammatory burden than RAnonILD, which correlated with higher mortality.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01
2024
2024-01-01
2025
2025-01-14
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12466/5118
url http://hdl.handle.net/20.500.12466/5118
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial 4.0 Internacional
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
instname:Universidad Católica de Valencia San Vicente Mártir
instname_str Universidad Católica de Valencia San Vicente Mártir
reponame_str RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
collection RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
repository.name.fl_str_mv
repository.mail.fl_str_mv
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