Exploring the relationship between trunk flexibility and arterial stiffness measured by pulse wave velocity: A systematic review and meta-analysis

Background As individuals age, the risk of cardiovascular disease (CVD) increases, largely due to progressive stiffening of the arteries. This relationship underscores the critical need to monitor arterial stiffness as a predictor of CVD outcomes. While aerobic exercise has demonstrated benefits for...

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Autores: Cavero Redondo, Iván, Fonseca, Helder, Otero Luis, Iris, Bohn, Lucimere, Lever Megina, Carla Geovanna, Moreno Herráiz, Nerea, Saz Lara, Alicia del
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/44897
Acceso en línea:https://hdl.handle.net/10578/44897
Access Level:acceso abierto
Palabra clave:Arterial stiffness
Pulse wave velocity
Trunk flexibility
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spelling Exploring the relationship between trunk flexibility and arterial stiffness measured by pulse wave velocity: A systematic review and meta-analysisCavero Redondo, IvánFonseca, HelderOtero Luis, IrisBohn, LucimereLever Megina, Carla GeovannaMoreno Herráiz, NereaSaz Lara, Alicia delArterial stiffnessPulse wave velocityTrunk flexibilityBackground As individuals age, the risk of cardiovascular disease (CVD) increases, largely due to progressive stiffening of the arteries. This relationship underscores the critical need to monitor arterial stiffness as a predictor of CVD outcomes. While aerobic exercise has demonstrated benefits for vascular health, the influence of flexibility, particularly trunk flexibility, on arterial stiffness remains underexplored. Thus, this study aimed to analyse the overall relationship between trunk flexibility and arterial stiffness across different age groups (young, middle-aged, and older adults) and according to sex. Methods A systematic review and meta-analysis were conducted following the MOOSE and JBI Manual for Evidence Synthesis on systematic reviews of etiology and risk guidelines. Searches in PubMed, Scopus, and Web of Science identified studies investigating the association between trunk flexibility and arterial stiffness measured by pulse wave velocity. Data extraction, quality assessment, and statistical analyses were performed following predefined criteria. Results Five studies involving 2797 participants were included. Poor trunk flexibility was associated with increased arterial stiffness compared to high flexibility (pooled standardized mean difference = -0.27, 95% CI: -0.39, -0.14), with substantial heterogeneity observed. Subgroup analyses by sex and age revealed significant associations predominantly in men and older individuals. Sensitivity analyses confirmed the robustness of the findings, and meta-regression models showed no significant differences according to age, BMI, or blood pressure. No evidence of publication bias was found. Conclusion Poor trunk flexibility is linked to elevated arterial stiffness across diverse demographic groups, highlighting its potential as a surrogate marker for cardiovascular health. Physiological mechanisms involving connective tissue integrity and neural regulation may underpin this relationship. Understanding the role of flexibility in arterial health could inform targeted interventions to mitigate age-related increases in arterial stiffness and reduce cardiovascular disease risk. However, further research is needed to validate these findings and explore potential sex-specific differences.PLOS One202520252024info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/10578/44897reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/448972026-05-27T07:36:41Z
dc.title.none.fl_str_mv Exploring the relationship between trunk flexibility and arterial stiffness measured by pulse wave velocity: A systematic review and meta-analysis
title Exploring the relationship between trunk flexibility and arterial stiffness measured by pulse wave velocity: A systematic review and meta-analysis
spellingShingle Exploring the relationship between trunk flexibility and arterial stiffness measured by pulse wave velocity: A systematic review and meta-analysis
Cavero Redondo, Iván
Arterial stiffness
Pulse wave velocity
Trunk flexibility
title_short Exploring the relationship between trunk flexibility and arterial stiffness measured by pulse wave velocity: A systematic review and meta-analysis
title_full Exploring the relationship between trunk flexibility and arterial stiffness measured by pulse wave velocity: A systematic review and meta-analysis
title_fullStr Exploring the relationship between trunk flexibility and arterial stiffness measured by pulse wave velocity: A systematic review and meta-analysis
title_full_unstemmed Exploring the relationship between trunk flexibility and arterial stiffness measured by pulse wave velocity: A systematic review and meta-analysis
title_sort Exploring the relationship between trunk flexibility and arterial stiffness measured by pulse wave velocity: A systematic review and meta-analysis
dc.creator.none.fl_str_mv Cavero Redondo, Iván
Fonseca, Helder
Otero Luis, Iris
Bohn, Lucimere
Lever Megina, Carla Geovanna
Moreno Herráiz, Nerea
Saz Lara, Alicia del
author Cavero Redondo, Iván
author_facet Cavero Redondo, Iván
Fonseca, Helder
Otero Luis, Iris
Bohn, Lucimere
Lever Megina, Carla Geovanna
Moreno Herráiz, Nerea
Saz Lara, Alicia del
author_role author
author2 Fonseca, Helder
Otero Luis, Iris
Bohn, Lucimere
Lever Megina, Carla Geovanna
Moreno Herráiz, Nerea
Saz Lara, Alicia del
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Arterial stiffness
Pulse wave velocity
Trunk flexibility
topic Arterial stiffness
Pulse wave velocity
Trunk flexibility
description Background As individuals age, the risk of cardiovascular disease (CVD) increases, largely due to progressive stiffening of the arteries. This relationship underscores the critical need to monitor arterial stiffness as a predictor of CVD outcomes. While aerobic exercise has demonstrated benefits for vascular health, the influence of flexibility, particularly trunk flexibility, on arterial stiffness remains underexplored. Thus, this study aimed to analyse the overall relationship between trunk flexibility and arterial stiffness across different age groups (young, middle-aged, and older adults) and according to sex. Methods A systematic review and meta-analysis were conducted following the MOOSE and JBI Manual for Evidence Synthesis on systematic reviews of etiology and risk guidelines. Searches in PubMed, Scopus, and Web of Science identified studies investigating the association between trunk flexibility and arterial stiffness measured by pulse wave velocity. Data extraction, quality assessment, and statistical analyses were performed following predefined criteria. Results Five studies involving 2797 participants were included. Poor trunk flexibility was associated with increased arterial stiffness compared to high flexibility (pooled standardized mean difference = -0.27, 95% CI: -0.39, -0.14), with substantial heterogeneity observed. Subgroup analyses by sex and age revealed significant associations predominantly in men and older individuals. Sensitivity analyses confirmed the robustness of the findings, and meta-regression models showed no significant differences according to age, BMI, or blood pressure. No evidence of publication bias was found. Conclusion Poor trunk flexibility is linked to elevated arterial stiffness across diverse demographic groups, highlighting its potential as a surrogate marker for cardiovascular health. Physiological mechanisms involving connective tissue integrity and neural regulation may underpin this relationship. Understanding the role of flexibility in arterial health could inform targeted interventions to mitigate age-related increases in arterial stiffness and reduce cardiovascular disease risk. However, further research is needed to validate these findings and explore potential sex-specific differences.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10578/44897
url https://hdl.handle.net/10578/44897
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv PLOS One
publisher.none.fl_str_mv PLOS One
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
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