Glycolysis – a key player in the inflammatory response

The inflammatory response involves the activation of several cell types to fight insults caused by a plethora of agents, and to maintain the tissue homoeostasis. On the one hand, cells involved in the pro-inflammatory response, such as inflammatory M1 macrophages, Th1 and Th17 lymphocytes or activat...

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Autores: Soto-Heredero, Gonzalo, Gómez de las Heras, Manuel M., Gabandé-Rodríguez, Enrique, Oller, Jorge, Mittelbrunn, María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/236451
Acceso en línea:http://hdl.handle.net/10261/236451
Access Level:acceso abierto
Palabra clave:Ageing
Immune cells
Immunometabolism
Inflammation
Metabolite
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spelling Glycolysis – a key player in the inflammatory responseSoto-Heredero, GonzaloGómez de las Heras, Manuel M.Gabandé-Rodríguez, EnriqueOller, JorgeMittelbrunn, MaríaAgeingImmune cellsImmunometabolismInflammationMetaboliteThe inflammatory response involves the activation of several cell types to fight insults caused by a plethora of agents, and to maintain the tissue homoeostasis. On the one hand, cells involved in the pro-inflammatory response, such as inflammatory M1 macrophages, Th1 and Th17 lymphocytes or activated microglia, must rapidly provide energy to fuel inflammation, which is essentially accomplished by glycolysis and high lactate production. On the other hand, regulatory T cells or M2 macrophages, which are involved in immune regulation and resolution of inflammation, preferentially use fatty acid oxidation through the TCA cycle as a main source for energy production. Here, we discuss the impact of glycolytic metabolism at the different steps of the inflammatory response. Finally, we review a wide variety of molecular mechanisms which could explain the relationship between glycolytic metabolites and the pro-inflammatory phenotype, including signalling events, epigenetic remodelling, post-transcriptional regulation and post-translational modifications. Inflammatory processes are a common feature of many age-associated diseases, such as cardiovascular and neurodegenerative disorders. The finding that immunometabolism could be a master regulator of inflammation broadens the avenue for treating inflammation-related pathologies through the manipulation of the vascular and immune cell metabolism.European Research Council (ERC-2016-StG 715322-EndoMitTalk), and Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI16/188, PI19/855), Fondo Europeo de Desarrollo Regional (FEDER). GS-H was funded by a FPIUAM grant (Universidad Autonoma de Madrid). MMGH was funded by ERC. EG-R was funded by a Juan de la Cierva grant (IJC2018-036850-I; Universidad Autónoma de Madrid). JO was funded by a Juan de la Cierva grant (FJCI-2017-33855; Universidad Autónoma de Madrid).European Research CouncilInstituto de Salud Carlos IIIUniversidad Autónoma de MadridConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/236451reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1111/febs.15327Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2364512026-05-22T06:33:51Z
dc.title.none.fl_str_mv Glycolysis – a key player in the inflammatory response
title Glycolysis – a key player in the inflammatory response
spellingShingle Glycolysis – a key player in the inflammatory response
Soto-Heredero, Gonzalo
Ageing
Immune cells
Immunometabolism
Inflammation
Metabolite
title_short Glycolysis – a key player in the inflammatory response
title_full Glycolysis – a key player in the inflammatory response
title_fullStr Glycolysis – a key player in the inflammatory response
title_full_unstemmed Glycolysis – a key player in the inflammatory response
title_sort Glycolysis – a key player in the inflammatory response
dc.creator.none.fl_str_mv Soto-Heredero, Gonzalo
Gómez de las Heras, Manuel M.
Gabandé-Rodríguez, Enrique
Oller, Jorge
Mittelbrunn, María
author Soto-Heredero, Gonzalo
author_facet Soto-Heredero, Gonzalo
Gómez de las Heras, Manuel M.
Gabandé-Rodríguez, Enrique
Oller, Jorge
Mittelbrunn, María
author_role author
author2 Gómez de las Heras, Manuel M.
Gabandé-Rodríguez, Enrique
Oller, Jorge
Mittelbrunn, María
author2_role author
author
author
author
dc.contributor.none.fl_str_mv European Research Council
Instituto de Salud Carlos III
Universidad Autónoma de Madrid
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Ageing
Immune cells
Immunometabolism
Inflammation
Metabolite
topic Ageing
Immune cells
Immunometabolism
Inflammation
Metabolite
description The inflammatory response involves the activation of several cell types to fight insults caused by a plethora of agents, and to maintain the tissue homoeostasis. On the one hand, cells involved in the pro-inflammatory response, such as inflammatory M1 macrophages, Th1 and Th17 lymphocytes or activated microglia, must rapidly provide energy to fuel inflammation, which is essentially accomplished by glycolysis and high lactate production. On the other hand, regulatory T cells or M2 macrophages, which are involved in immune regulation and resolution of inflammation, preferentially use fatty acid oxidation through the TCA cycle as a main source for energy production. Here, we discuss the impact of glycolytic metabolism at the different steps of the inflammatory response. Finally, we review a wide variety of molecular mechanisms which could explain the relationship between glycolytic metabolites and the pro-inflammatory phenotype, including signalling events, epigenetic remodelling, post-transcriptional regulation and post-translational modifications. Inflammatory processes are a common feature of many age-associated diseases, such as cardiovascular and neurodegenerative disorders. The finding that immunometabolism could be a master regulator of inflammation broadens the avenue for treating inflammation-related pathologies through the manipulation of the vascular and immune cell metabolism.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/236451
url http://hdl.handle.net/10261/236451
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1111/febs.15327
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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