Analysis of Genomic Regions Associated With Coronary Artery Disease Reveals Continent-Specific Single Nucleotide Polymorphisms in North African Populations.

ACKGROUND: In recent years, several genomic regions have been robustly associated with coronary artery disease (CAD) in different genome-wide association studies (GWASs) conducted mainly in people of European descent. These kinds of data are lacking in African populations, even though heart diseases...

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Autores: Zanetti, Daniela, Via i García, Marc, Carreras Torres, Robert, Esteban i Torné, Maria Esther, Chaabani, Hassen, Anaibar, Fatima, Harich, Nourdin, Habbal, Rachida, Ghalim, Noreddine, Moral Castrillo, Pedro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/102548
Acceso en línea:https://hdl.handle.net/2445/102548
Access Level:acceso abierto
Palabra clave:Genètica de poblacions humanes
Malalties coronàries
Factors de risc en les malalties
Human population genetics
Coronary diseases
Risk factors in diseases
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spelling Analysis of Genomic Regions Associated With Coronary Artery Disease Reveals Continent-Specific Single Nucleotide Polymorphisms in North African Populations.Zanetti, DanielaVia i García, MarcCarreras Torres, RobertEsteban i Torné, Maria EstherChaabani, HassenAnaibar, FatimaHarich, NourdinHabbal, RachidaGhalim, NoreddineMoral Castrillo, PedroGenètica de poblacions humanesMalalties coronàriesFactors de risc en les malaltiesHuman population geneticsCoronary diseasesRisk factors in diseasesACKGROUND: In recent years, several genomic regions have been robustly associated with coronary artery disease (CAD) in different genome-wide association studies (GWASs) conducted mainly in people of European descent. These kinds of data are lacking in African populations, even though heart diseases are a major cause of premature death and disability. METHODS: Here, 384 single nucleotide polymorphisms (SNPs) in the top four CAD risk regions (1p13, 1q41, 9p21, and 10q11) were genotyped in 274 case-control samples from Morocco and Tunisia, with the aim of analyzing for the first time if the associations found in European populations were transferable to North Africans. RESULTS: The results indicate that, as in Europe, these four genetic regions are also important for CAD risk in North Africa. However, the individual SNPs associated with CAD in Africa are different from those identified in Europe in most cases (1p13, 1q41, and 9p21). Moreover, the seven risk variants identified in North Africans are efficient in discriminating between cases and controls in North African populations, but not in European populations. CONCLUSIONS: This study indicates a disparity in markers associated to CAD susceptibility between North Africans and Europeans that may be related to population differences in the chromosomal architecture of these risk regions.Japan Epidemiological Association2016201620162016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfhttps://hdl.handle.net/2445/102548Articles publicats en revistes (Psicologia Clínica i Psicobiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.2188/jea.JE20150034Journal of Epidemiology, 2016, vol. 26, num. 5, p. 264-271http://dx.doi.org/10.2188/jea.JE20150034cc-by (c) Zanetti, D. et al., 2016http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1025482026-05-29T05:05:01Z
dc.title.none.fl_str_mv Analysis of Genomic Regions Associated With Coronary Artery Disease Reveals Continent-Specific Single Nucleotide Polymorphisms in North African Populations.
title Analysis of Genomic Regions Associated With Coronary Artery Disease Reveals Continent-Specific Single Nucleotide Polymorphisms in North African Populations.
spellingShingle Analysis of Genomic Regions Associated With Coronary Artery Disease Reveals Continent-Specific Single Nucleotide Polymorphisms in North African Populations.
Zanetti, Daniela
Genètica de poblacions humanes
Malalties coronàries
Factors de risc en les malalties
Human population genetics
Coronary diseases
Risk factors in diseases
title_short Analysis of Genomic Regions Associated With Coronary Artery Disease Reveals Continent-Specific Single Nucleotide Polymorphisms in North African Populations.
title_full Analysis of Genomic Regions Associated With Coronary Artery Disease Reveals Continent-Specific Single Nucleotide Polymorphisms in North African Populations.
title_fullStr Analysis of Genomic Regions Associated With Coronary Artery Disease Reveals Continent-Specific Single Nucleotide Polymorphisms in North African Populations.
title_full_unstemmed Analysis of Genomic Regions Associated With Coronary Artery Disease Reveals Continent-Specific Single Nucleotide Polymorphisms in North African Populations.
title_sort Analysis of Genomic Regions Associated With Coronary Artery Disease Reveals Continent-Specific Single Nucleotide Polymorphisms in North African Populations.
dc.creator.none.fl_str_mv Zanetti, Daniela
Via i García, Marc
Carreras Torres, Robert
Esteban i Torné, Maria Esther
Chaabani, Hassen
Anaibar, Fatima
Harich, Nourdin
Habbal, Rachida
Ghalim, Noreddine
Moral Castrillo, Pedro
author Zanetti, Daniela
author_facet Zanetti, Daniela
Via i García, Marc
Carreras Torres, Robert
Esteban i Torné, Maria Esther
Chaabani, Hassen
Anaibar, Fatima
Harich, Nourdin
Habbal, Rachida
Ghalim, Noreddine
Moral Castrillo, Pedro
author_role author
author2 Via i García, Marc
Carreras Torres, Robert
Esteban i Torné, Maria Esther
Chaabani, Hassen
Anaibar, Fatima
Harich, Nourdin
Habbal, Rachida
Ghalim, Noreddine
Moral Castrillo, Pedro
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Genètica de poblacions humanes
Malalties coronàries
Factors de risc en les malalties
Human population genetics
Coronary diseases
Risk factors in diseases
topic Genètica de poblacions humanes
Malalties coronàries
Factors de risc en les malalties
Human population genetics
Coronary diseases
Risk factors in diseases
description ACKGROUND: In recent years, several genomic regions have been robustly associated with coronary artery disease (CAD) in different genome-wide association studies (GWASs) conducted mainly in people of European descent. These kinds of data are lacking in African populations, even though heart diseases are a major cause of premature death and disability. METHODS: Here, 384 single nucleotide polymorphisms (SNPs) in the top four CAD risk regions (1p13, 1q41, 9p21, and 10q11) were genotyped in 274 case-control samples from Morocco and Tunisia, with the aim of analyzing for the first time if the associations found in European populations were transferable to North Africans. RESULTS: The results indicate that, as in Europe, these four genetic regions are also important for CAD risk in North Africa. However, the individual SNPs associated with CAD in Africa are different from those identified in Europe in most cases (1p13, 1q41, and 9p21). Moreover, the seven risk variants identified in North Africans are efficient in discriminating between cases and controls in North African populations, but not in European populations. CONCLUSIONS: This study indicates a disparity in markers associated to CAD susceptibility between North Africans and Europeans that may be related to population differences in the chromosomal architecture of these risk regions.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/102548
url https://hdl.handle.net/2445/102548
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.2188/jea.JE20150034
Journal of Epidemiology, 2016, vol. 26, num. 5, p. 264-271
http://dx.doi.org/10.2188/jea.JE20150034
dc.rights.none.fl_str_mv cc-by (c) Zanetti, D. et al., 2016
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Zanetti, D. et al., 2016
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8 p.
application/pdf
dc.publisher.none.fl_str_mv Japan Epidemiological Association
publisher.none.fl_str_mv Japan Epidemiological Association
dc.source.none.fl_str_mv Articles publicats en revistes (Psicologia Clínica i Psicobiologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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