Economic Evaluation of Traditional Treatments for Localized Prostate Cancer
Objectives: To perform a cost-effectiveness analysis based on primary data from a cohort of patients with localized prostate cancer followed throughout 10 years, comparing radical prostatectomy, brachytherapy, and external beam radiotherapy (EBRT) and applying disease-specific utilities, from a nati...
| Autores: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:320046 |
| Acesso em linha: | https://ddd.uab.cat/record/320046 https://dx.doi.org/urn:doi:10.1155/ecc/3563061 |
| Access Level: | acceso abierto |
| Palavra-chave: | Cost-utility analysis Economic evaluation External radiotherapy Localized prostate cancer Preplanned brachytherapy QALYs Quality-adjusted life years Radical prostatectomy |
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España |
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| dc.title.none.fl_str_mv |
Economic Evaluation of Traditional Treatments for Localized Prostate Cancer A 10-Year Cohort Study |
| title |
Economic Evaluation of Traditional Treatments for Localized Prostate Cancer |
| spellingShingle |
Economic Evaluation of Traditional Treatments for Localized Prostate Cancer Zamora, Víctor|||0000-0003-2061-0052 Cost-utility analysis Economic evaluation External radiotherapy Localized prostate cancer Preplanned brachytherapy QALYs Quality-adjusted life years Radical prostatectomy |
| title_short |
Economic Evaluation of Traditional Treatments for Localized Prostate Cancer |
| title_full |
Economic Evaluation of Traditional Treatments for Localized Prostate Cancer |
| title_fullStr |
Economic Evaluation of Traditional Treatments for Localized Prostate Cancer |
| title_full_unstemmed |
Economic Evaluation of Traditional Treatments for Localized Prostate Cancer |
| title_sort |
Economic Evaluation of Traditional Treatments for Localized Prostate Cancer |
| dc.creator.none.fl_str_mv |
Zamora, Víctor|||0000-0003-2061-0052 Bosch, Guillermo Becerra, Virginia|||0000-0002-8811-3899 Garin, Olatz|||0000-0001-6193-0779 Ávila, Mónica|||0000-0001-9583-5104 Gutiérrez Miguélez, Cristina|||0000-0002-6944-772X Suárez, José Francisco|||0000-0001-6427-4391 Goñi, Alai|||0000-0002-6365-9617 Macías Hernández, Víctor|||0000-0003-2904-5715 Mariño, Alfonso|||0000-0002-6720-3916 Hervás Morón, Asunción|||0000-0002-7439-1820 Herruzo, I. Cabrera, Patricia|||0000-0001-6050-7354 Ponce de León Roca, Javier|||0000-0003-0250-2533 Sancho-Pardo, Gemma|||0000-0003-2266-6172 Pont, À. Rubio-Valera, M. Alonso, Jordi|||0000-0001-8627-9636 Cots Reguant, Francesc|||0000-0003-0238-8902 Guedea, Ferran|||0000-0001-8798-8696 Castells-Esteve, Manel|||0000-0003-2370-2008 Ferrer, M. |
| author |
Zamora, Víctor|||0000-0003-2061-0052 |
| author_facet |
Zamora, Víctor|||0000-0003-2061-0052 Bosch, Guillermo Becerra, Virginia|||0000-0002-8811-3899 Garin, Olatz|||0000-0001-6193-0779 Ávila, Mónica|||0000-0001-9583-5104 Gutiérrez Miguélez, Cristina|||0000-0002-6944-772X Suárez, José Francisco|||0000-0001-6427-4391 Goñi, Alai|||0000-0002-6365-9617 Macías Hernández, Víctor|||0000-0003-2904-5715 Mariño, Alfonso|||0000-0002-6720-3916 Hervás Morón, Asunción|||0000-0002-7439-1820 Herruzo, I. Cabrera, Patricia|||0000-0001-6050-7354 Ponce de León Roca, Javier|||0000-0003-0250-2533 Sancho-Pardo, Gemma|||0000-0003-2266-6172 Pont, À. Rubio-Valera, M. Alonso, Jordi|||0000-0001-8627-9636 Cots Reguant, Francesc|||0000-0003-0238-8902 Guedea, Ferran|||0000-0001-8798-8696 Castells-Esteve, Manel|||0000-0003-2370-2008 Ferrer, M. |
| author_role |
author |
| author2 |
Bosch, Guillermo Becerra, Virginia|||0000-0002-8811-3899 Garin, Olatz|||0000-0001-6193-0779 Ávila, Mónica|||0000-0001-9583-5104 Gutiérrez Miguélez, Cristina|||0000-0002-6944-772X Suárez, José Francisco|||0000-0001-6427-4391 Goñi, Alai|||0000-0002-6365-9617 Macías Hernández, Víctor|||0000-0003-2904-5715 Mariño, Alfonso|||0000-0002-6720-3916 Hervás Morón, Asunción|||0000-0002-7439-1820 Herruzo, I. Cabrera, Patricia|||0000-0001-6050-7354 Ponce de León Roca, Javier|||0000-0003-0250-2533 Sancho-Pardo, Gemma|||0000-0003-2266-6172 Pont, À. Rubio-Valera, M. Alonso, Jordi|||0000-0001-8627-9636 Cots Reguant, Francesc|||0000-0003-0238-8902 Guedea, Ferran|||0000-0001-8798-8696 Castells-Esteve, Manel|||0000-0003-2370-2008 Ferrer, M. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Cost-utility analysis Economic evaluation External radiotherapy Localized prostate cancer Preplanned brachytherapy QALYs Quality-adjusted life years Radical prostatectomy |
| topic |
Cost-utility analysis Economic evaluation External radiotherapy Localized prostate cancer Preplanned brachytherapy QALYs Quality-adjusted life years Radical prostatectomy |
| description |
Objectives: To perform a cost-effectiveness analysis based on primary data from a cohort of patients with localized prostate cancer followed throughout 10 years, comparing radical prostatectomy, brachytherapy, and external beam radiotherapy (EBRT) and applying disease-specific utilities, from a national health system's perspective. Materials and Methods: Patients diagnosed with localized prostate cancer were consecutively recruited in 2003-2005 from 10 Spanish hospitals (n = 674) (ClinicalTrials.gov number: NCT01492751). The expanded prostate cancer index composite (EPIC) and short-form 36 (SF-36) questionnaires were administered through telephone interviews before treatment and annually during follow-up. The outcome measures to evaluate the incremental cost-effectiveness ratio between treatments (ICER) were quality-adjusted life-years (QALYs), calculated by the patient-oriented prostate utility scale (PORPUS) utility index, obtained with a mapping from the EPIC and the SF-36, and survival data. Ten-year medical activities were used to derive costs. Both unweighted and propensity score-weighted analyses were performed. Results: The weighted mean of 10-year QALYs was the highest for radical prostatectomy (8.53), followed by brachytherapy (8.49) and external radiotherapy (8.20), but the difference was only statistically significant with the latter. Costs were significantly higher for brachytherapy (€21,348) than radical prostatectomy (€12,281) and EBRT (€7,560). Compared to EBRT, the weighted ICER for radical prostatectomy was €14,169/QALY gained and €48,417/QALY for brachytherapy. Conclusion: Our findings support that radical prostatectomy was the most cost-effective alternative, but the differences in effectiveness among the three treatments were small. The incremental cost of radical prostatectomy and brachytherapy compared to EBRT, however, does not justify restricting these alternatives. Trial Registration: ClinicalTrials.gov identifier: NCT01492751. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2 2025-01-01 2025 2025-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/320046 https://dx.doi.org/urn:doi:10.1155/ecc/3563061 |
| url |
https://ddd.uab.cat/record/320046 https://dx.doi.org/urn:doi:10.1155/ecc/3563061 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI21/00023 Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI08/90090 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI13/00412 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00624 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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1869409150331518976 |
| spelling |
Economic Evaluation of Traditional Treatments for Localized Prostate CancerA 10-Year Cohort StudyZamora, Víctor|||0000-0003-2061-0052Bosch, GuillermoBecerra, Virginia|||0000-0002-8811-3899Garin, Olatz|||0000-0001-6193-0779Ávila, Mónica|||0000-0001-9583-5104Gutiérrez Miguélez, Cristina|||0000-0002-6944-772XSuárez, José Francisco|||0000-0001-6427-4391Goñi, Alai|||0000-0002-6365-9617Macías Hernández, Víctor|||0000-0003-2904-5715Mariño, Alfonso|||0000-0002-6720-3916Hervás Morón, Asunción|||0000-0002-7439-1820Herruzo, I.Cabrera, Patricia|||0000-0001-6050-7354Ponce de León Roca, Javier|||0000-0003-0250-2533Sancho-Pardo, Gemma|||0000-0003-2266-6172Pont, À.Rubio-Valera, M.Alonso, Jordi|||0000-0001-8627-9636Cots Reguant, Francesc|||0000-0003-0238-8902Guedea, Ferran|||0000-0001-8798-8696Castells-Esteve, Manel|||0000-0003-2370-2008Ferrer, M.Cost-utility analysisEconomic evaluationExternal radiotherapyLocalized prostate cancerPreplanned brachytherapyQALYsQuality-adjusted life yearsRadical prostatectomyObjectives: To perform a cost-effectiveness analysis based on primary data from a cohort of patients with localized prostate cancer followed throughout 10 years, comparing radical prostatectomy, brachytherapy, and external beam radiotherapy (EBRT) and applying disease-specific utilities, from a national health system's perspective. Materials and Methods: Patients diagnosed with localized prostate cancer were consecutively recruited in 2003-2005 from 10 Spanish hospitals (n = 674) (ClinicalTrials.gov number: NCT01492751). The expanded prostate cancer index composite (EPIC) and short-form 36 (SF-36) questionnaires were administered through telephone interviews before treatment and annually during follow-up. The outcome measures to evaluate the incremental cost-effectiveness ratio between treatments (ICER) were quality-adjusted life-years (QALYs), calculated by the patient-oriented prostate utility scale (PORPUS) utility index, obtained with a mapping from the EPIC and the SF-36, and survival data. Ten-year medical activities were used to derive costs. Both unweighted and propensity score-weighted analyses were performed. Results: The weighted mean of 10-year QALYs was the highest for radical prostatectomy (8.53), followed by brachytherapy (8.49) and external radiotherapy (8.20), but the difference was only statistically significant with the latter. Costs were significantly higher for brachytherapy (€21,348) than radical prostatectomy (€12,281) and EBRT (€7,560). Compared to EBRT, the weighted ICER for radical prostatectomy was €14,169/QALY gained and €48,417/QALY for brachytherapy. Conclusion: Our findings support that radical prostatectomy was the most cost-effective alternative, but the differences in effectiveness among the three treatments were small. The incremental cost of radical prostatectomy and brachytherapy compared to EBRT, however, does not justify restricting these alternatives. Trial Registration: ClinicalTrials.gov identifier: NCT01492751.Universitat Autònoma de Barcelona 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/320046https://dx.doi.org/urn:doi:10.1155/ecc/3563061reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI21/00023Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI08/90090Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI13/00412Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00624open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3200462026-06-06T12:50:31Z |
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15,812429 |