Green Solvent-Assisted Coaxial Electrospinning of PVA/PLLA Nanofibers with Tailored Morphology and Diffusion-Controlled Transport
Green solvent strategies are increasingly important for advancing sustainable polymer processing and deepening the understanding of structure-property relationships. In this work, we report a coaxial electrospinning approach that employs dimethyl sulfoxide and ethyl acetate as environmentally benign...
| Autores: | , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2026 |
| País: | España |
| Recursos: | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| Repositorio: | r-FISABIO. Repositorio Institucional de Producción Científica |
| OAI Identifier: | oai:dnet:r-fisabio___::9e21fd4e1d4e733433c22c080bf749f7 |
| Acesso em linha: | https://fisabio.portalinvestigacion.com/publicaciones/21208 |
| Access Level: | acceso abierto |
| Palavra-chave: | Green solvents Drug delivery Polymers Controlled release Coaxial electrospinning Polyvinyl alcohol Poly(l-lactic acid) |
| Resumo: | Green solvent strategies are increasingly important for advancing sustainable polymer processing and deepening the understanding of structure-property relationships. In this work, we report a coaxial electrospinning approach that employs dimethyl sulfoxide and ethyl acetate as environmentally benign solvents to fabricate nanofibers composed of polyvinyl alcohol (PVA) cores and poly(L-lactic acid) (PLLA) shells. Comprehensive morphological and physicochemical characterization confirmed the successful formation of uniform, defect-free core-shell architectures. Comparative transport studies revealed clear architecture-dependent behavior: uniaxial PVA fibers displayed rapid burst release, PLLA-only fibers acted as complete diffusion barriers, and coaxial PVA/PLLA fibers enabled finely tunable, diffusion-controlled transport over extended timescales. These findings establish direct links between solvent choice, processing architecture, and transport properties in biodegradable nanofiber systems. This study provides both a scalable eco-conscious electrospinning strategy and a fundamental framework for correlating processing, morphology, and mass transport in polymeric materials. |
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