Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity
Increased voluntary consumption of alcohol has been demonstrated in male rats exposed to frustrative reward downshift (the emotional self-medication effect). Access to a wheel for voluntary running abolished this effect in male rats, suggesting an attenuating effect of physical exercise on the negat...
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad Nacional de Educación a Distancia |
| Repositorio: | e-spacio. Repositorio Institucional de la UNED |
| Idioma: | inglés |
| OAI Identifier: | oai:e-spacio.uned.es:20.500.14468/31460 |
| Acceso en línea: | https://hdl.handle.net/20.500.14468/31460 |
| Access Level: | acceso embargado |
| Palabra clave: | 6106 Psicología experimental Alcohol consumption Emotional self-medication Female rats Frustration Physical activity Reward downshif Wheel running |
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Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activityCastejón, ElenaAmbrosio Flores, EmilioPellón Suárez de Puga, RicardoTorres, Carmen6106 Psicología experimentalAlcohol consumptionEmotional self-medicationFemale ratsFrustrationPhysical activityReward downshifWheel runningIncreased voluntary consumption of alcohol has been demonstrated in male rats exposed to frustrative reward downshift (the emotional self-medication effect). Access to a wheel for voluntary running abolished this effect in male rats, suggesting an attenuating effect of physical exercise on the negative affect induced by reward downshift and its consequences on drug intake. The present study analyzed this effect in female rats. Sixty-four food-deprived female Wistar rats received 32% sucrose [4% (Experiment 1) or 2% (Experiment 2) in controls] during 10, 5-min preshift sessions followed by 4% (Experiment 1) or 2% (Experiment 2) sucrose during 5 postshift sessions. Immediately after each consummatory session, animals were exposed to a 2-h, two-bottle preference test involving 32% alcohol vs. water. Half of the animals also had access to a running wheel during the preference test. The results showed (a) lower sucrose consumption in the downshifted groups (32–4% and 32–2%) compared to the unshifted controls (4–4% and 2–2%, respectively); (b) higher alcohol preference in downshifted groups without access to a wheel compared with downshifted groups with access to the wheel (Experiments 1 and 2); and (c) increased alcohol intake (g/kg) after experiencing reward downshift in animals without access to the wheel (Experiment 1). Voluntary wheel running thus reduced alcohol intake in female rats experiencing reward downshift. These findings are comparable to previous results reported in male rats and support the usefulness of physical exercise to prevent alcohol self-medication induced by frustrative nonreward.Lippincott, Williams & Wilkinse-Spacio UNED20262026-01-1920252025-04-0120252025-04-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14468/31460reponame:e-spacio. Repositorio Institucional de la UNEDinstname:Universidad Nacional de Educación a DistanciaInglésengembargoed accesshttp://purl.org/coar/access_right/c_f1cfinfo:eu-repo/semantics/embargoedAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.esoai:e-spacio.uned.es:20.500.14468/314602026-06-06T12:38:31Z |
| dc.title.none.fl_str_mv |
Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity |
| title |
Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity |
| spellingShingle |
Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity Castejón, Elena 6106 Psicología experimental Alcohol consumption Emotional self-medication Female rats Frustration Physical activity Reward downshif Wheel running |
| title_short |
Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity |
| title_full |
Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity |
| title_fullStr |
Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity |
| title_full_unstemmed |
Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity |
| title_sort |
Alcohol consumption and preference in female rats induced by reward downshift reveals sex generality of the modulatory role of physical activity |
| dc.creator.none.fl_str_mv |
Castejón, Elena Ambrosio Flores, Emilio Pellón Suárez de Puga, Ricardo Torres, Carmen |
| author |
Castejón, Elena |
| author_facet |
Castejón, Elena Ambrosio Flores, Emilio Pellón Suárez de Puga, Ricardo Torres, Carmen |
| author_role |
author |
| author2 |
Ambrosio Flores, Emilio Pellón Suárez de Puga, Ricardo Torres, Carmen |
| author2_role |
author author author |
| dc.contributor.none.fl_str_mv |
e-Spacio UNED |
| dc.subject.none.fl_str_mv |
6106 Psicología experimental Alcohol consumption Emotional self-medication Female rats Frustration Physical activity Reward downshif Wheel running |
| topic |
6106 Psicología experimental Alcohol consumption Emotional self-medication Female rats Frustration Physical activity Reward downshif Wheel running |
| description |
Increased voluntary consumption of alcohol has been demonstrated in male rats exposed to frustrative reward downshift (the emotional self-medication effect). Access to a wheel for voluntary running abolished this effect in male rats, suggesting an attenuating effect of physical exercise on the negative affect induced by reward downshift and its consequences on drug intake. The present study analyzed this effect in female rats. Sixty-four food-deprived female Wistar rats received 32% sucrose [4% (Experiment 1) or 2% (Experiment 2) in controls] during 10, 5-min preshift sessions followed by 4% (Experiment 1) or 2% (Experiment 2) sucrose during 5 postshift sessions. Immediately after each consummatory session, animals were exposed to a 2-h, two-bottle preference test involving 32% alcohol vs. water. Half of the animals also had access to a running wheel during the preference test. The results showed (a) lower sucrose consumption in the downshifted groups (32–4% and 32–2%) compared to the unshifted controls (4–4% and 2–2%, respectively); (b) higher alcohol preference in downshifted groups without access to a wheel compared with downshifted groups with access to the wheel (Experiments 1 and 2); and (c) increased alcohol intake (g/kg) after experiencing reward downshift in animals without access to the wheel (Experiment 1). Voluntary wheel running thus reduced alcohol intake in female rats experiencing reward downshift. These findings are comparable to previous results reported in male rats and support the usefulness of physical exercise to prevent alcohol self-medication induced by frustrative nonreward. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2025-04-01 2025 2025-04-01 2026 2026-01-19 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.14468/31460 |
| url |
https://hdl.handle.net/20.500.14468/31460 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
embargoed access http://purl.org/coar/access_right/c_f1cf info:eu-repo/semantics/embargoedAccess http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
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embargoed access http://purl.org/coar/access_right/c_f1cf http://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
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embargoedAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Lippincott, Williams & Wilkins |
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Lippincott, Williams & Wilkins |
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reponame:e-spacio. Repositorio Institucional de la UNED instname:Universidad Nacional de Educación a Distancia |
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Universidad Nacional de Educación a Distancia |
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e-spacio. Repositorio Institucional de la UNED |
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e-spacio. Repositorio Institucional de la UNED |
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15.81155 |