Tuning the matrix: recent advances in mechanobiology unveiled through polyacrylamide hydrogels

Over the past 30 years, polyacrylamide (PAAm) hydrogels have become essential tools to mimic the mechanical properties, chemical composition, and dimensionality of the extracellular matrix (ECM) in in vitro mechanobiology studies. This brief review highlights recent developments that have transforme...

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Detalles Bibliográficos
Autores: Ciccone, Giuseppe, Salmeron-Sanchez, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/221726
Acceso en línea:https://hdl.handle.net/2445/221726
Access Level:acceso abierto
Palabra clave:Matriu extracel·lular
Materials biomèdics
Extracellular matrix
Biomedical materials
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spelling Tuning the matrix: recent advances in mechanobiology unveiled through polyacrylamide hydrogelsCiccone, GiuseppeSalmeron-Sanchez, ManuelMatriu extracel·lularMaterials biomèdicsExtracellular matrixBiomedical materialsOver the past 30 years, polyacrylamide (PAAm) hydrogels have become essential tools to mimic the mechanical properties, chemical composition, and dimensionality of the extracellular matrix (ECM) in in vitro mechanobiology studies. This brief review highlights recent developments that have transformed PAAm hydrogels from simple 2D static elastic hydrogels to complex ECM-mimicking systems involving protein micropatterning, mechanical patterning, stretching, DNA tension probes, viscoelasticity, and the microfabrication of 3D systems. We focus on novel mechanobiological questions that have been elucidated using these platforms and give a perspective on the future of PAAm hydrogels for mechanobiology research.Elsevier2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/221726Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.cobme.2025.100604Curr Opin Biomed Eng, 2025, vol. 35https://doi.org/10.1016/j.cobme.2025.100604cc-by-nc-nd (c) Ciccone, Giuseppe et al., 2025http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2217262026-05-29T05:05:01Z
dc.title.none.fl_str_mv Tuning the matrix: recent advances in mechanobiology unveiled through polyacrylamide hydrogels
title Tuning the matrix: recent advances in mechanobiology unveiled through polyacrylamide hydrogels
spellingShingle Tuning the matrix: recent advances in mechanobiology unveiled through polyacrylamide hydrogels
Ciccone, Giuseppe
Matriu extracel·lular
Materials biomèdics
Extracellular matrix
Biomedical materials
title_short Tuning the matrix: recent advances in mechanobiology unveiled through polyacrylamide hydrogels
title_full Tuning the matrix: recent advances in mechanobiology unveiled through polyacrylamide hydrogels
title_fullStr Tuning the matrix: recent advances in mechanobiology unveiled through polyacrylamide hydrogels
title_full_unstemmed Tuning the matrix: recent advances in mechanobiology unveiled through polyacrylamide hydrogels
title_sort Tuning the matrix: recent advances in mechanobiology unveiled through polyacrylamide hydrogels
dc.creator.none.fl_str_mv Ciccone, Giuseppe
Salmeron-Sanchez, Manuel
author Ciccone, Giuseppe
author_facet Ciccone, Giuseppe
Salmeron-Sanchez, Manuel
author_role author
author2 Salmeron-Sanchez, Manuel
author2_role author
dc.subject.none.fl_str_mv Matriu extracel·lular
Materials biomèdics
Extracellular matrix
Biomedical materials
topic Matriu extracel·lular
Materials biomèdics
Extracellular matrix
Biomedical materials
description Over the past 30 years, polyacrylamide (PAAm) hydrogels have become essential tools to mimic the mechanical properties, chemical composition, and dimensionality of the extracellular matrix (ECM) in in vitro mechanobiology studies. This brief review highlights recent developments that have transformed PAAm hydrogels from simple 2D static elastic hydrogels to complex ECM-mimicking systems involving protein micropatterning, mechanical patterning, stretching, DNA tension probes, viscoelasticity, and the microfabrication of 3D systems. We focus on novel mechanobiological questions that have been elucidated using these platforms and give a perspective on the future of PAAm hydrogels for mechanobiology research.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/221726
url https://hdl.handle.net/2445/221726
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.cobme.2025.100604
Curr Opin Biomed Eng, 2025, vol. 35
https://doi.org/10.1016/j.cobme.2025.100604
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Ciccone, Giuseppe et al., 2025
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Ciccone, Giuseppe et al., 2025
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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