Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica

Thematic Issue: Crystal Ball.

Detalles Bibliográficos
Autores: Chhun, Audam, Sousoni, Despoina, Aguiló-Ferretjans, María del Mar, Song, Lijiang, Corre, Christophe, Christie-Oleza, Joseph Alexander
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/257482
Acceso en línea:http://hdl.handle.net/10261/257482
Access Level:acceso abierto
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spelling Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropicaChhun, AudamSousoni, DespoinaAguiló-Ferretjans, María del MarSong, LijiangCorre, ChristopheChristie-Oleza, Joseph AlexanderThematic Issue: Crystal Ball.Filamentous members of the phylum Actinobacteria are a remarkable source of natural products with pharmaceutical potential. The discovery of novel molecules from these organisms is, however, hindered because most of the biosynthetic gene clusters (BGCs) encoding these secondary metabolites are cryptic or silent and are referred to as orphan BGCs. While co-culture has proven to be a promising approach to unlock the biosynthetic potential of many microorganisms by activating the expression of these orphan BGCs, it still remains an underexplored technique. The marine actinobacterium Salinispora tropica, for instance, produces valuable compounds such as the anti-cancer molecule salinosporamide but half of its putative BGCs are still orphan. Although previous studies have used marine heterotrophs to induce orphan BGCs in Salinispora, its co-culture with marine phototrophs has yet to be investigated. Following the observation of an antimicrobial activity against a range of phytoplankton by S. tropica, we here report that the photosynthate released by photosynthetic primary producers influences its biosynthetic capacities with production of cryptic molecules and the activation of orphan BGCs. Our work, using an approach combining metabolomics and proteomics, pioneers the use of phototrophs as a promising strategy to accelerate the discovery of novel natural products from marine actinobacteria.A.C. was supported by an MIBTP PhD scholarship (BB/M01116X/1) and D.S. by a NERC CENTA DTP studentship (NE/L002493/1). J.A.C.-O was funded by a NERC Independent Research Fellowship NE/K009044/1 and Ramón y Cajal contract RYC-2017-22452 (funded by the Ministry of Science, Innovation and Universities, the National Agency of Research, and the European Social Fund). C.C. thanks BBSRC (grant BB/M022765/1) and European Union’s Horizon 2020 research No. 765147 for support. L.S. would like to acknowledge BBSRC (BB/M017982/1 and BB/R000689/1) and EPSRC (EP/P0305721/1) for financial support.John Wiley & SonsNatural Environment Research Council (UK)Ministerio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionBiotechnology and Biological Sciences Research Council (UK)Engineering and Physical Sciences Research Council (UK)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/257482reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MICINN//RYC-2017-22452info:eu-repo/grantAgreement/EC/H2020/765147http://dx.doi.org/10.1111/1751-7915.13722Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2574822026-05-22T06:33:51Z
dc.title.none.fl_str_mv Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica
title Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica
spellingShingle Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica
Chhun, Audam
title_short Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica
title_full Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica
title_fullStr Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica
title_full_unstemmed Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica
title_sort Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica
dc.creator.none.fl_str_mv Chhun, Audam
Sousoni, Despoina
Aguiló-Ferretjans, María del Mar
Song, Lijiang
Corre, Christophe
Christie-Oleza, Joseph Alexander
author Chhun, Audam
author_facet Chhun, Audam
Sousoni, Despoina
Aguiló-Ferretjans, María del Mar
Song, Lijiang
Corre, Christophe
Christie-Oleza, Joseph Alexander
author_role author
author2 Sousoni, Despoina
Aguiló-Ferretjans, María del Mar
Song, Lijiang
Corre, Christophe
Christie-Oleza, Joseph Alexander
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Natural Environment Research Council (UK)
Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Biotechnology and Biological Sciences Research Council (UK)
Engineering and Physical Sciences Research Council (UK)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description Thematic Issue: Crystal Ball.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/257482
url http://hdl.handle.net/10261/257482
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MICINN//RYC-2017-22452
info:eu-repo/grantAgreement/EC/H2020/765147
http://dx.doi.org/10.1111/1751-7915.13722
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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