When GETomics meets aging and exercise in COPD

The term GETomics has been recently proposed to illustrate that human health and disease are actually the final outcome of many dynamic, interacting and cumulative gene (G) - environment (E) interactions that occur through the lifetime (T) of the individual. According to this new paradigm, the final...

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Autores: Pellegrino, D., Casas Recasens, Sandra, Faner, Rosa, Palange, P., Agustí García-Navarro, Àlvar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/219689
Acceso en línea:https://hdl.handle.net/2445/219689
Access Level:acceso abierto
Palabra clave:Bronquitis
Espirometria
Hàbit de fumar
Emfisema pulmonar
Bronchitis
Spirometry
Smoking
Pulmonary emphysema
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spelling When GETomics meets aging and exercise in COPDPellegrino, D.Casas Recasens, SandraFaner, RosaPalange, P.Agustí García-Navarro, ÀlvarBronquitisEspirometriaHàbit de fumarEmfisema pulmonarBronchitisSpirometrySmokingPulmonary emphysemaThe term GETomics has been recently proposed to illustrate that human health and disease are actually the final outcome of many dynamic, interacting and cumulative gene (G) - environment (E) interactions that occur through the lifetime (T) of the individual. According to this new paradigm, the final outcome of any GxE interactions depends on both the age of the individual at which such GxE interaction occurs as well as on the previous, cumulative history of previous GxE interactions through the induction of epigenetic changes and immune memory (both lasting overtime). Following this conceptual approach, our understanding of the pathogenesis of chronic obstructive pulmonary disease (COPD) has changed dramatically. Traditionally believed to be a self-inflicted disease induced by tobacco smoking occurring in older men and characterized by an accelerated decline of lung function with age, now we understand that there are many other risk factors associated with COPD, that it occurs also in females and young individuals, that there are different lung function trajectories through life, and that COPD is not always characterized by accelerated lung function decline. In this paper we discuss how a GETomics approach to COPD may open new perspectives to better understand its relationship with exercise limitation and the ageing process.Elsevier B.V.2025202520232025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion7 p.application/pdfhttps://hdl.handle.net/2445/219689Articles publicats en revistes (Biomedicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.rmed.2023.107294Respiratory Medicine, 2023, vol. 216https://doi.org/10.1016/j.rmed.2023.107294cc-by-nc-nd (c) Pellegrino, D. et al., 2023http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2196892026-05-29T05:05:01Z
dc.title.none.fl_str_mv When GETomics meets aging and exercise in COPD
title When GETomics meets aging and exercise in COPD
spellingShingle When GETomics meets aging and exercise in COPD
Pellegrino, D.
Bronquitis
Espirometria
Hàbit de fumar
Emfisema pulmonar
Bronchitis
Spirometry
Smoking
Pulmonary emphysema
title_short When GETomics meets aging and exercise in COPD
title_full When GETomics meets aging and exercise in COPD
title_fullStr When GETomics meets aging and exercise in COPD
title_full_unstemmed When GETomics meets aging and exercise in COPD
title_sort When GETomics meets aging and exercise in COPD
dc.creator.none.fl_str_mv Pellegrino, D.
Casas Recasens, Sandra
Faner, Rosa
Palange, P.
Agustí García-Navarro, Àlvar
author Pellegrino, D.
author_facet Pellegrino, D.
Casas Recasens, Sandra
Faner, Rosa
Palange, P.
Agustí García-Navarro, Àlvar
author_role author
author2 Casas Recasens, Sandra
Faner, Rosa
Palange, P.
Agustí García-Navarro, Àlvar
author2_role author
author
author
author
dc.subject.none.fl_str_mv Bronquitis
Espirometria
Hàbit de fumar
Emfisema pulmonar
Bronchitis
Spirometry
Smoking
Pulmonary emphysema
topic Bronquitis
Espirometria
Hàbit de fumar
Emfisema pulmonar
Bronchitis
Spirometry
Smoking
Pulmonary emphysema
description The term GETomics has been recently proposed to illustrate that human health and disease are actually the final outcome of many dynamic, interacting and cumulative gene (G) - environment (E) interactions that occur through the lifetime (T) of the individual. According to this new paradigm, the final outcome of any GxE interactions depends on both the age of the individual at which such GxE interaction occurs as well as on the previous, cumulative history of previous GxE interactions through the induction of epigenetic changes and immune memory (both lasting overtime). Following this conceptual approach, our understanding of the pathogenesis of chronic obstructive pulmonary disease (COPD) has changed dramatically. Traditionally believed to be a self-inflicted disease induced by tobacco smoking occurring in older men and characterized by an accelerated decline of lung function with age, now we understand that there are many other risk factors associated with COPD, that it occurs also in females and young individuals, that there are different lung function trajectories through life, and that COPD is not always characterized by accelerated lung function decline. In this paper we discuss how a GETomics approach to COPD may open new perspectives to better understand its relationship with exercise limitation and the ageing process.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/219689
url https://hdl.handle.net/2445/219689
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.rmed.2023.107294
Respiratory Medicine, 2023, vol. 216
https://doi.org/10.1016/j.rmed.2023.107294
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Pellegrino, D. et al., 2023
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Pellegrino, D. et al., 2023
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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