Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations.

INTRODUCTION: Auditory hallucinations (AH) are one of the most prevalent symptoms of schizophrenia. They might cause several brain alterations, especially changes in the volumes of hippocampus and amygdala, regions related to the relay and processing of auditory cues and emotional memories.; MATERIA...

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Autores: Perez-Rando, Marta, Penades-Gomiz, Carlota, Martinez-Marin, Pablo, Garcia-Marti, Gracian, Aguilar, Eduardo J, Escarti, Maria J, Grasa, Eva, Corripio, Iluminada, Sanjuan, Julio, Nacher, Juan
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2023
País:España
Recursos:INCLIVA
Repositório:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p18256
Acesso em linha:https://incliva.portalinvestigacion.com/publicaciones/18256
Access Level:Acceso aberto
Palavra-chave:Alucinaciones auditivas
Amygdala
Amígdala
Auditory hallucinations
Esquizofrenia
Hipocampo
Hippocampus
Schizophrenia
Segmentación
Segmentation
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spelling Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations.Perez-Rando, MartaPenades-Gomiz, CarlotaMartinez-Marin, PabloGarcia-Marti, GracianAguilar, Eduardo JEscarti, Maria JGrasa, EvaCorripio, IluminadaSanjuan, JulioNacher, JuanAlucinaciones auditivasAmygdalaAmígdalaAuditory hallucinationsEsquizofreniaHipocampoHippocampusSchizophreniaSegmentaciónSegmentationINTRODUCTION: Auditory hallucinations (AH) are one of the most prevalent symptoms of schizophrenia. They might cause several brain alterations, especially changes in the volumes of hippocampus and amygdala, regions related to the relay and processing of auditory cues and emotional memories.; MATERIAL AND METHODS: We have recruited 41 patients with schizophrenia and persistent AH, 35 patients without AH, and 55 healthy controls. Using their MRIs, we have performed semiautomatic segmentations of the hippocampus and amygdala using Freesurfer. We have also performed bilateral correlations between the total PSYRATS score and the volumes of affected subregions and nuclei.; RESULTS: In the hippocampus, we found bilateral increases in the volume of its hippocampal fissure and decreases in the right fimbria in patients with and without AH. The volume of the right hippocampal tail and left head of the granule cell layer from the dentate gyrus were decreased in patients with AH. In the amygdala, we found its left total volume was shrunk, and there was a decrease of its left accessory basal nucleus in patients with AH.; CONCLUSIONS: We have detected volume alterations of different limbic structures likely due to the presence of AH. The volumes of the right hippocampal tail and left head of the granule cell layer from the dentate gyrus, and total volume of the amygdala and its accessory basal nucleus, were only affected in patients with AH. Bilateral volume alterations in the hippocampal fissure and right fimbria seem inherent of schizophrenia and due to traits not contemplated in our research. Copyright © 2023 The Authors. Publicado por Elsevier Espana, S.L.U. All rights reserved.ELSEVIER ESPANA SLU2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/18256Revista de Psiquiatria y Salud MentalISSN: 18889891ISSNe: 19894600reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAEspañolinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p182562026-06-07T16:35:31Z
dc.title.none.fl_str_mv Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations.
title Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations.
spellingShingle Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations.
Perez-Rando, Marta
Alucinaciones auditivas
Amygdala
Amígdala
Auditory hallucinations
Esquizofrenia
Hipocampo
Hippocampus
Schizophrenia
Segmentación
Segmentation
title_short Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations.
title_full Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations.
title_fullStr Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations.
title_full_unstemmed Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations.
title_sort Volume alterations of the hippocampus and amygdala in patients with schizophrenia and persistent auditory hallucinations.
dc.creator.none.fl_str_mv Perez-Rando, Marta
Penades-Gomiz, Carlota
Martinez-Marin, Pablo
Garcia-Marti, Gracian
Aguilar, Eduardo J
Escarti, Maria J
Grasa, Eva
Corripio, Iluminada
Sanjuan, Julio
Nacher, Juan
author Perez-Rando, Marta
author_facet Perez-Rando, Marta
Penades-Gomiz, Carlota
Martinez-Marin, Pablo
Garcia-Marti, Gracian
Aguilar, Eduardo J
Escarti, Maria J
Grasa, Eva
Corripio, Iluminada
Sanjuan, Julio
Nacher, Juan
author_role author
author2 Penades-Gomiz, Carlota
Martinez-Marin, Pablo
Garcia-Marti, Gracian
Aguilar, Eduardo J
Escarti, Maria J
Grasa, Eva
Corripio, Iluminada
Sanjuan, Julio
Nacher, Juan
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alucinaciones auditivas
Amygdala
Amígdala
Auditory hallucinations
Esquizofrenia
Hipocampo
Hippocampus
Schizophrenia
Segmentación
Segmentation
topic Alucinaciones auditivas
Amygdala
Amígdala
Auditory hallucinations
Esquizofrenia
Hipocampo
Hippocampus
Schizophrenia
Segmentación
Segmentation
description INTRODUCTION: Auditory hallucinations (AH) are one of the most prevalent symptoms of schizophrenia. They might cause several brain alterations, especially changes in the volumes of hippocampus and amygdala, regions related to the relay and processing of auditory cues and emotional memories.; MATERIAL AND METHODS: We have recruited 41 patients with schizophrenia and persistent AH, 35 patients without AH, and 55 healthy controls. Using their MRIs, we have performed semiautomatic segmentations of the hippocampus and amygdala using Freesurfer. We have also performed bilateral correlations between the total PSYRATS score and the volumes of affected subregions and nuclei.; RESULTS: In the hippocampus, we found bilateral increases in the volume of its hippocampal fissure and decreases in the right fimbria in patients with and without AH. The volume of the right hippocampal tail and left head of the granule cell layer from the dentate gyrus were decreased in patients with AH. In the amygdala, we found its left total volume was shrunk, and there was a decrease of its left accessory basal nucleus in patients with AH.; CONCLUSIONS: We have detected volume alterations of different limbic structures likely due to the presence of AH. The volumes of the right hippocampal tail and left head of the granule cell layer from the dentate gyrus, and total volume of the amygdala and its accessory basal nucleus, were only affected in patients with AH. Bilateral volume alterations in the hippocampal fissure and right fimbria seem inherent of schizophrenia and due to traits not contemplated in our research. Copyright © 2023 The Authors. Publicado por Elsevier Espana, S.L.U. All rights reserved.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/18256
url https://incliva.portalinvestigacion.com/publicaciones/18256
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER ESPANA SLU
publisher.none.fl_str_mv ELSEVIER ESPANA SLU
dc.source.none.fl_str_mv Revista de Psiquiatria y Salud Mental
ISSN: 18889891
ISSNe: 19894600
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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