Mitochondrial function and dysfunction in innate immunity

The mitochondria play an important role in the activation of the innate immune system. This organelle modulates the metabolic reprogramming of the immune cell into proinflammatory or anti-inflammatory subtypes, which typically utilize very different metabolic pathways to fulfill their functions. It...

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Detalhes bibliográficos
Autores: Oliva, Aurea, Meroño, Carolina, Traba, Javier
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/370132
Acesso em linha:http://hdl.handle.net/10261/370132
Access Level:acceso abierto
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spelling Mitochondrial function and dysfunction in innate immunityOliva, AureaMeroño, CarolinaTraba, JavierThe mitochondria play an important role in the activation of the innate immune system. This organelle modulates the metabolic reprogramming of the immune cell into proinflammatory or anti-inflammatory subtypes, which typically utilize very different metabolic pathways to fulfill their functions. It also acts as a signaling platform to activate immune routes in both immune and nonimmune cells, as it can generate agonists for inflammatory pathways, including toll-like receptors, inflammasomes, or the cyclic GMP–AMP synthase–stimulator of interferon genes pathway, which lead to the generation of proinflammatory cytokines and antiviral molecules such as type-I interferons. These novel functions of the mitochondria are important in the fight against pathogens, but also contribute to human disease when dysregulated. This review describes recent findings in this field and highlights the role of mitochondrial nucleic acids in the regulation of innate immune signaling pathways.This work was supported by the Ministry of Science and Innovation (MICINN) of Spain (grants RYC2018-026050-I and PID2019-105665RAI00 to JT) and by an institutional grant from the Fundación Ramon Areces to the Centro de Biología Molecular Severo Ochoa. CM is the recipient of a Contrato Predoctoral para la Formación de Doctores from MICINN (PRE2020-094403, associated with grant PID2019-105665RA-I00 to JT), and AO is supported by a researcher contract from Comunidad de Madrid (grant PEJ-2020-AI/BMD-17941 to JT).Ministerio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Fundación Ramón ArecesComunidad de MadridConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420222024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/370132reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105665RA-I00http://dx.doi.org/10.1016/j.cophys.2022.100571Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3701322026-05-22T06:33:51Z
dc.title.none.fl_str_mv Mitochondrial function and dysfunction in innate immunity
title Mitochondrial function and dysfunction in innate immunity
spellingShingle Mitochondrial function and dysfunction in innate immunity
Oliva, Aurea
title_short Mitochondrial function and dysfunction in innate immunity
title_full Mitochondrial function and dysfunction in innate immunity
title_fullStr Mitochondrial function and dysfunction in innate immunity
title_full_unstemmed Mitochondrial function and dysfunction in innate immunity
title_sort Mitochondrial function and dysfunction in innate immunity
dc.creator.none.fl_str_mv Oliva, Aurea
Meroño, Carolina
Traba, Javier
author Oliva, Aurea
author_facet Oliva, Aurea
Meroño, Carolina
Traba, Javier
author_role author
author2 Meroño, Carolina
Traba, Javier
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Fundación Ramón Areces
Comunidad de Madrid
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description The mitochondria play an important role in the activation of the innate immune system. This organelle modulates the metabolic reprogramming of the immune cell into proinflammatory or anti-inflammatory subtypes, which typically utilize very different metabolic pathways to fulfill their functions. It also acts as a signaling platform to activate immune routes in both immune and nonimmune cells, as it can generate agonists for inflammatory pathways, including toll-like receptors, inflammasomes, or the cyclic GMP–AMP synthase–stimulator of interferon genes pathway, which lead to the generation of proinflammatory cytokines and antiviral molecules such as type-I interferons. These novel functions of the mitochondria are important in the fight against pathogens, but also contribute to human disease when dysregulated. This review describes recent findings in this field and highlights the role of mitochondrial nucleic acids in the regulation of innate immune signaling pathways.
publishDate 2022
dc.date.none.fl_str_mv 2022
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/370132
url http://hdl.handle.net/10261/370132
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105665RA-I00
http://dx.doi.org/10.1016/j.cophys.2022.100571
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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