Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes

The mammalian telencephalon is considered the most complex of all biological structures. It comprises a large number of functionally and morphologically distinct types of neurons that coordinately control most aspects of cognition and behavior. The subpallium, for example, not only gives rise to mul...

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Detalles Bibliográficos
Autores: Flames, Nuria, Pla, Ramón, Gelman, Diego M., Rubenstein, J. L. R., Puelles, Luis, Marín Parra, Óscar
Tipo de recurso: artículo
Fecha de publicación:2007
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/36829
Acceso en línea:http://hdl.handle.net/10261/36829
Access Level:acceso abierto
Palabra clave:Telencephalon
Subpallium
Patterning
Cell specification
Interneuron diversity
Cortex
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spelling Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codesFlames, NuriaPla, RamónGelman, Diego M.Rubenstein, J. L. R.Puelles, LuisMarín Parra, ÓscarTelencephalonSubpalliumPatterningCell specificationInterneuron diversityCortexThe mammalian telencephalon is considered the most complex of all biological structures. It comprises a large number of functionally and morphologically distinct types of neurons that coordinately control most aspects of cognition and behavior. The subpallium, for example, not only gives rise to multiple neuronal types that form the basal ganglia and parts of the amygdala and septum but also is the origin of an astonishing diversity of cortical interneurons. Despite our detailed knowledge on the molecular, morphological, and physiological properties of most of these neuronal populations, the mechanisms underlying their generation are still poorly understood. Here, we comprehensively analyzed the expression patterns of several transcription factors in the ventricular zone of the developing subpallium in the mouse to generate a detailed molecular map of the different progenitor domains present in this region. Our study demonstrates that the ventricular zone of the mouse subpallium contains at least 18 domains that are uniquely defined by the combinatorial expression of several transcription factors. Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains.This work was supported by grants from the Spanish Government (BFU2005-04773/BMC), Fundació “la Caixa,” the European Commission through Specific Targeted Research Project Contract 005139 (INTERDEVO), and the European Young Investigator Award (EURYI) program (O.M.); from Spanish Government BFU2005-09378-C02-01 (L.P.); and from Nina Ireland and by National Institute of Mental Health Grants R01 MH49428 and K05 MH065670 (to J.L.R.R.).Peer reviewedSociety for Neuroscience201120112007info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/36829reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1523/​JNEUROSCI.2750-07.2007info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/368292026-05-22T06:33:51Z
dc.title.none.fl_str_mv Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
title Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
spellingShingle Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
Flames, Nuria
Telencephalon
Subpallium
Patterning
Cell specification
Interneuron diversity
Cortex
title_short Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
title_full Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
title_fullStr Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
title_full_unstemmed Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
title_sort Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
dc.creator.none.fl_str_mv Flames, Nuria
Pla, Ramón
Gelman, Diego M.
Rubenstein, J. L. R.
Puelles, Luis
Marín Parra, Óscar
author Flames, Nuria
author_facet Flames, Nuria
Pla, Ramón
Gelman, Diego M.
Rubenstein, J. L. R.
Puelles, Luis
Marín Parra, Óscar
author_role author
author2 Pla, Ramón
Gelman, Diego M.
Rubenstein, J. L. R.
Puelles, Luis
Marín Parra, Óscar
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Telencephalon
Subpallium
Patterning
Cell specification
Interneuron diversity
Cortex
topic Telencephalon
Subpallium
Patterning
Cell specification
Interneuron diversity
Cortex
description The mammalian telencephalon is considered the most complex of all biological structures. It comprises a large number of functionally and morphologically distinct types of neurons that coordinately control most aspects of cognition and behavior. The subpallium, for example, not only gives rise to multiple neuronal types that form the basal ganglia and parts of the amygdala and septum but also is the origin of an astonishing diversity of cortical interneurons. Despite our detailed knowledge on the molecular, morphological, and physiological properties of most of these neuronal populations, the mechanisms underlying their generation are still poorly understood. Here, we comprehensively analyzed the expression patterns of several transcription factors in the ventricular zone of the developing subpallium in the mouse to generate a detailed molecular map of the different progenitor domains present in this region. Our study demonstrates that the ventricular zone of the mouse subpallium contains at least 18 domains that are uniquely defined by the combinatorial expression of several transcription factors. Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains.
publishDate 2007
dc.date.none.fl_str_mv 2007
2011
2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/36829
url http://hdl.handle.net/10261/36829
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1523/​JNEUROSCI.2750-07.2007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Society for Neuroscience
publisher.none.fl_str_mv Society for Neuroscience
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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