Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?

Gallego-Martínez, A. (Alejandro)|||/items/437119c2-c61d-44a5-ba77-48f604100084; Escudero, J. (Javier)|||/items/360186d4-010c-43f0-8777-14b9ce4ab6b6; Heredia-Soto, V. (Victoria)|||/items/ad2fe025-f2d5-4e49-9922-6b6e3359ec8b; Wang, Y. (Yinyin)|||/items/26b194b1-842b-4817-b6db-cd7d25d5a4bf; Ruiz, P. (Patricia)|||/items/da9567d7-83cf-4bf8-b627-fadac558cd66; Hu, Y. (Yingying)|||/items/874772e8-a66c-4bcd-b1f7-76fc0b172a28; Pozo-Kreilinger, J. J. (José Juan)|||/items/d61e1082-b59d-4fc3-a354-8585ccab5cd6; Martínez-Marín, V. (Virginia)|||/items/479473f6-0c8e-43ad-9413-edf664086749; Berjón, A. (Alberto)|||/items/6e6dec67-e604-4eea-9a0d-96ea43634310; Ortiz, E. (Eduardo)|||/items/28d04fa2-ef9c-4ed7-ab83-5b04440d298e; Bernabeu, D. (Daniel)|||/items/1d49790c-aa99-4ce6-bec4-f21517b44875; Feliu-Batlle, J. (Jaime)|||/items/1e8e4959-01e5-4535-81d4-8832eef0b97b; Tang, J. (Jing)|||/items/b8968415-3879-4f4b-8f6f-bdbc3f06e1cf; Redondo, A. (Andrés)|||/items/5b04343b-22f2-40cf-b7cc-baf6069e5305; Mendiola, M. (Marta)|||/items/885a2b36-d49a-488d-8086-179e790facf0

Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?

Background Eribulin has shown antitumour activity in some soft tissue sarcomas (STSs), but it has only been approved for advanced liposarcoma (LPS). Methods In this study, we evaluated the effect of eribulin on proliferation, migration and invasion capabilities in LPS, leiomyosarcoma (LMS) and fibro...

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Detalhes bibliográficos
Autores:	Gallego-Martínez, A. (Alejandro)\|\|\|/items/437119c2-c61d-44a5-ba77-48f604100084, Escudero, J. (Javier)\|\|\|/items/360186d4-010c-43f0-8777-14b9ce4ab6b6, Heredia-Soto, V. (Victoria)\|\|\|/items/ad2fe025-f2d5-4e49-9922-6b6e3359ec8b, Wang, Y. (Yinyin)\|\|\|/items/26b194b1-842b-4817-b6db-cd7d25d5a4bf, Ruiz, P. (Patricia)\|\|\|/items/da9567d7-83cf-4bf8-b627-fadac558cd66, Hu, Y. (Yingying)\|\|\|/items/874772e8-a66c-4bcd-b1f7-76fc0b172a28, Pozo-Kreilinger, J. J. (José Juan)\|\|\|/items/d61e1082-b59d-4fc3-a354-8585ccab5cd6, Martínez-Marín, V. (Virginia)\|\|\|/items/479473f6-0c8e-43ad-9413-edf664086749, Berjón, A. (Alberto)\|\|\|/items/6e6dec67-e604-4eea-9a0d-96ea43634310, Ortiz, E. (Eduardo)\|\|\|/items/28d04fa2-ef9c-4ed7-ab83-5b04440d298e, Bernabeu, D. (Daniel)\|\|\|/items/1d49790c-aa99-4ce6-bec4-f21517b44875, Feliu-Batlle, J. (Jaime)\|\|\|/items/1e8e4959-01e5-4535-81d4-8832eef0b97b, Tang, J. (Jing)\|\|\|/items/b8968415-3879-4f4b-8f6f-bdbc3f06e1cf, Redondo, A. (Andrés)\|\|\|/items/5b04343b-22f2-40cf-b7cc-baf6069e5305, Mendiola, M. (Marta)\|\|\|/items/885a2b36-d49a-488d-8086-179e790facf0
Formato:	artículo
Fecha de publicación:	2021
País:	España
Recursos:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/69011
Acesso em linha:	https://hdl.handle.net/10171/69011
Access Level:	acceso abierto
Palavra-chave:	Eribulin Sarcoma Proliferation Migration Invasion 2D and 3D models

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spelling	Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?Gallego-Martínez, A. (Alejandro)\|\|\|/items/437119c2-c61d-44a5-ba77-48f604100084Escudero, J. (Javier)\|\|\|/items/360186d4-010c-43f0-8777-14b9ce4ab6b6Heredia-Soto, V. (Victoria)\|\|\|/items/ad2fe025-f2d5-4e49-9922-6b6e3359ec8bWang, Y. (Yinyin)\|\|\|/items/26b194b1-842b-4817-b6db-cd7d25d5a4bfRuiz, P. (Patricia)\|\|\|/items/da9567d7-83cf-4bf8-b627-fadac558cd66Hu, Y. (Yingying)\|\|\|/items/874772e8-a66c-4bcd-b1f7-76fc0b172a28Pozo-Kreilinger, J. J. (José Juan)\|\|\|/items/d61e1082-b59d-4fc3-a354-8585ccab5cd6Martínez-Marín, V. (Virginia)\|\|\|/items/479473f6-0c8e-43ad-9413-edf664086749Berjón, A. (Alberto)\|\|\|/items/6e6dec67-e604-4eea-9a0d-96ea43634310Ortiz, E. (Eduardo)\|\|\|/items/28d04fa2-ef9c-4ed7-ab83-5b04440d298eBernabeu, D. (Daniel)\|\|\|/items/1d49790c-aa99-4ce6-bec4-f21517b44875Feliu-Batlle, J. (Jaime)\|\|\|/items/1e8e4959-01e5-4535-81d4-8832eef0b97bTang, J. (Jing)\|\|\|/items/b8968415-3879-4f4b-8f6f-bdbc3f06e1cfRedondo, A. (Andrés)\|\|\|/items/5b04343b-22f2-40cf-b7cc-baf6069e5305Mendiola, M. (Marta)\|\|\|/items/885a2b36-d49a-488d-8086-179e790facf0EribulinSarcomaProliferationMigrationInvasion2D and 3D modelsBackground Eribulin has shown antitumour activity in some soft tissue sarcomas (STSs), but it has only been approved for advanced liposarcoma (LPS). Methods In this study, we evaluated the effect of eribulin on proliferation, migration and invasion capabilities in LPS, leiomyosarcoma (LMS) and fibrosarcoma (FS) models, using both monolayer (2D) and three-dimensional (3D) spheroid cell cultures. Additionally, we explored combinations of eribulin with other drugs commonly used in the treatment of STS with the aim of increasing its antitumour activity. Results Eribulin showed activity inhibiting proliferation, 2D and 3D migration and invasion in most of the cell line models. Furthermore, we provide data that suggest, for the first time, a synergistic effect with ifosfamide in all models, and with pazopanib in LMS as well as in myxoid and pleomorphic LPS. Conclusions Our results support the effect of eribulin on LPS, LMS and FS cell line models. The combination of eribulin with ifosfamide or pazopanib has shown in vitro synergy, which warrants further clinical research.Dadun. Depósito Académico Digital Universidad de Navarra20242024-02-0920212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/69011reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/690112026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?
title	Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?
spellingShingle	Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect? Gallego-Martínez, A. (Alejandro)\|\|\|/items/437119c2-c61d-44a5-ba77-48f604100084 Eribulin Sarcoma Proliferation Migration Invasion 2D and 3D models
title_short	Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?
title_full	Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?
title_fullStr	Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?
title_full_unstemmed	Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?
title_sort	Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?
dc.creator.none.fl_str_mv	Gallego-Martínez, A. (Alejandro)\|\|\|/items/437119c2-c61d-44a5-ba77-48f604100084 Escudero, J. (Javier)\|\|\|/items/360186d4-010c-43f0-8777-14b9ce4ab6b6 Heredia-Soto, V. (Victoria)\|\|\|/items/ad2fe025-f2d5-4e49-9922-6b6e3359ec8b Wang, Y. (Yinyin)\|\|\|/items/26b194b1-842b-4817-b6db-cd7d25d5a4bf Ruiz, P. (Patricia)\|\|\|/items/da9567d7-83cf-4bf8-b627-fadac558cd66 Hu, Y. (Yingying)\|\|\|/items/874772e8-a66c-4bcd-b1f7-76fc0b172a28 Pozo-Kreilinger, J. J. (José Juan)\|\|\|/items/d61e1082-b59d-4fc3-a354-8585ccab5cd6 Martínez-Marín, V. (Virginia)\|\|\|/items/479473f6-0c8e-43ad-9413-edf664086749 Berjón, A. (Alberto)\|\|\|/items/6e6dec67-e604-4eea-9a0d-96ea43634310 Ortiz, E. (Eduardo)\|\|\|/items/28d04fa2-ef9c-4ed7-ab83-5b04440d298e Bernabeu, D. (Daniel)\|\|\|/items/1d49790c-aa99-4ce6-bec4-f21517b44875 Feliu-Batlle, J. (Jaime)\|\|\|/items/1e8e4959-01e5-4535-81d4-8832eef0b97b Tang, J. (Jing)\|\|\|/items/b8968415-3879-4f4b-8f6f-bdbc3f06e1cf Redondo, A. (Andrés)\|\|\|/items/5b04343b-22f2-40cf-b7cc-baf6069e5305 Mendiola, M. (Marta)\|\|\|/items/885a2b36-d49a-488d-8086-179e790facf0
author	Gallego-Martínez, A. (Alejandro)\|\|\|/items/437119c2-c61d-44a5-ba77-48f604100084
author_facet	Gallego-Martínez, A. (Alejandro)\|\|\|/items/437119c2-c61d-44a5-ba77-48f604100084 Escudero, J. (Javier)\|\|\|/items/360186d4-010c-43f0-8777-14b9ce4ab6b6 Heredia-Soto, V. (Victoria)\|\|\|/items/ad2fe025-f2d5-4e49-9922-6b6e3359ec8b Wang, Y. (Yinyin)\|\|\|/items/26b194b1-842b-4817-b6db-cd7d25d5a4bf Ruiz, P. (Patricia)\|\|\|/items/da9567d7-83cf-4bf8-b627-fadac558cd66 Hu, Y. (Yingying)\|\|\|/items/874772e8-a66c-4bcd-b1f7-76fc0b172a28 Pozo-Kreilinger, J. J. (José Juan)\|\|\|/items/d61e1082-b59d-4fc3-a354-8585ccab5cd6 Martínez-Marín, V. (Virginia)\|\|\|/items/479473f6-0c8e-43ad-9413-edf664086749 Berjón, A. (Alberto)\|\|\|/items/6e6dec67-e604-4eea-9a0d-96ea43634310 Ortiz, E. (Eduardo)\|\|\|/items/28d04fa2-ef9c-4ed7-ab83-5b04440d298e Bernabeu, D. (Daniel)\|\|\|/items/1d49790c-aa99-4ce6-bec4-f21517b44875 Feliu-Batlle, J. (Jaime)\|\|\|/items/1e8e4959-01e5-4535-81d4-8832eef0b97b Tang, J. (Jing)\|\|\|/items/b8968415-3879-4f4b-8f6f-bdbc3f06e1cf Redondo, A. (Andrés)\|\|\|/items/5b04343b-22f2-40cf-b7cc-baf6069e5305 Mendiola, M. (Marta)\|\|\|/items/885a2b36-d49a-488d-8086-179e790facf0
author_role	author
author2	Escudero, J. (Javier)\|\|\|/items/360186d4-010c-43f0-8777-14b9ce4ab6b6 Heredia-Soto, V. (Victoria)\|\|\|/items/ad2fe025-f2d5-4e49-9922-6b6e3359ec8b Wang, Y. (Yinyin)\|\|\|/items/26b194b1-842b-4817-b6db-cd7d25d5a4bf Ruiz, P. (Patricia)\|\|\|/items/da9567d7-83cf-4bf8-b627-fadac558cd66 Hu, Y. (Yingying)\|\|\|/items/874772e8-a66c-4bcd-b1f7-76fc0b172a28 Pozo-Kreilinger, J. J. (José Juan)\|\|\|/items/d61e1082-b59d-4fc3-a354-8585ccab5cd6 Martínez-Marín, V. (Virginia)\|\|\|/items/479473f6-0c8e-43ad-9413-edf664086749 Berjón, A. (Alberto)\|\|\|/items/6e6dec67-e604-4eea-9a0d-96ea43634310 Ortiz, E. (Eduardo)\|\|\|/items/28d04fa2-ef9c-4ed7-ab83-5b04440d298e Bernabeu, D. (Daniel)\|\|\|/items/1d49790c-aa99-4ce6-bec4-f21517b44875 Feliu-Batlle, J. (Jaime)\|\|\|/items/1e8e4959-01e5-4535-81d4-8832eef0b97b Tang, J. (Jing)\|\|\|/items/b8968415-3879-4f4b-8f6f-bdbc3f06e1cf Redondo, A. (Andrés)\|\|\|/items/5b04343b-22f2-40cf-b7cc-baf6069e5305 Mendiola, M. (Marta)\|\|\|/items/885a2b36-d49a-488d-8086-179e790facf0
author2_role	author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Eribulin Sarcoma Proliferation Migration Invasion 2D and 3D models
topic	Eribulin Sarcoma Proliferation Migration Invasion 2D and 3D models
description	Background Eribulin has shown antitumour activity in some soft tissue sarcomas (STSs), but it has only been approved for advanced liposarcoma (LPS). Methods In this study, we evaluated the effect of eribulin on proliferation, migration and invasion capabilities in LPS, leiomyosarcoma (LMS) and fibrosarcoma (FS) models, using both monolayer (2D) and three-dimensional (3D) spheroid cell cultures. Additionally, we explored combinations of eribulin with other drugs commonly used in the treatment of STS with the aim of increasing its antitumour activity. Results Eribulin showed activity inhibiting proliferation, 2D and 3D migration and invasion in most of the cell line models. Furthermore, we provide data that suggest, for the first time, a synergistic effect with ifosfamide in all models, and with pazopanib in LMS as well as in myxoid and pleomorphic LPS. Conclusions Our results support the effect of eribulin on LPS, LMS and FS cell line models. The combination of eribulin with ifosfamide or pazopanib has shown in vitro synergy, which warrants further clinical research.
publishDate	2021
dc.date.none.fl_str_mv	2021 2021-01-01 2021 2021-01-01 2024 2024-02-09
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/69011
url	https://hdl.handle.net/10171/69011
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
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collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
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Eribulin activity in soft tissue sarcoma monolayer and three-dimensional cell line models: could the combination with other drugs improve its antitumoral effect?

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