Neuroanatomical differences between first-episode psychosis patients with and without neurocognitive deficit: a 3-year longitudinal study

This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY).

Detalles Bibliográficos
Autores: Ayesa Arriola, Rosa, Roiz-Santiáñez, Roberto, Pérez-Iglesias, Rocío, Ferro, Adele, Sainz, Jesús, Crespo-Facorro, Benedicto
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/130421
Acceso en línea:http://hdl.handle.net/10261/130421
Access Level:acceso abierto
Palabra clave:Neuroanatomical
Neurocognition
Schizophrenia
Cognitive deficit
First-episode psychosis
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spelling Neuroanatomical differences between first-episode psychosis patients with and without neurocognitive deficit: a 3-year longitudinal studyAyesa Arriola, RosaRoiz-Santiáñez, RobertoPérez-Iglesias, RocíoFerro, AdeleSainz, JesúsCrespo-Facorro, BenedictoNeuroanatomicalNeurocognitionSchizophreniaCognitive deficitFirst-episode psychosisThis is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY).[Background]: The course of cognitive function in first-episode psychosis (FEP) patients suggests that some individuals are normal or near normal whereas some cases present a marked decline. The goal of the present longitudinal study was to identify neuroanatomical differences between deficit and non-deficit patients. [Methods]: Fifty nine FEP patients with neuroimage and neurocognitive information were studied at baseline and 3 year after illness onset. A global cognitive function score was used to classify deficit and non-deficit patients at baseline. Analysis of covariances and repeated-measures analysis were performed to evaluate differences in brain volumes. Age, premorbid IQ, and intracranial volume were used as covariates. We examined only volumes of whole brain, whole brain gray and white matter, cortical CSF and lateral ventricles, lobular volumes of gray and white matter, and subcortical (caudate nucleus and thalamus) regions. [Results]: At illness onset 50.8% of patients presented global cognitive deficit. There were no significant differences between neuropsychological subgroups in any of the brain regions studied at baseline [all F(1, 54) ≤ 3.42; all p ≥ 0.07] and follow-up [all F(1, 54) ≤ 3.43; all p ≥ 0.07] time points. There was a significant time by group interaction for the parietal tissue volume [F(1, 54) = 4.97, p = 0.030] and the total gray matter volume [F(1, 54) = 4.31, p = 0.042], with the deficit group showing a greater volume decrease. [Conclusion]: Our results did not confirm the presence of significant morphometric differences in the brain regions evaluated between cognitively impaired and cognitively preserved schizophrenia patients at the early stages of the illness. However, there were significant time by group interactions for the parietal tissue volume and the total gray matter volume during the 3-year follow-up period, which might indicate that cognitive deficit in schizophrenia would be associated with progressive brain volume loss.The present study was carried out at the Hospital Marqués de Valdecilla, University of Cantabria, Santander, Spain, under the following grant support: Instituto de Salud Carlos III PI020499, PI050427, PI060507, PI1000183, SENY Fundació Research Grant CI 2005-0308007, and Fundación Marqués de Valdecilla API07/011. We wish to thank the PAFIP researchers. Adele Ferro was sustained by the funds of the 2007/2013 European Social Fund Operational Programme of the Autonomous Region Friuli Venezia Giulia.Peer ReviewedFrontiers MediaInstituto de Salud Carlos IIIUniversidad de CantabriaInstituto de Investigación Marqués de ValdecillaEuropean CommissionFundació SenyConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2016201620132016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/130421reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3389/fpsyt.2013.00134Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1304212026-05-22T06:33:51Z
dc.title.none.fl_str_mv Neuroanatomical differences between first-episode psychosis patients with and without neurocognitive deficit: a 3-year longitudinal study
title Neuroanatomical differences between first-episode psychosis patients with and without neurocognitive deficit: a 3-year longitudinal study
spellingShingle Neuroanatomical differences between first-episode psychosis patients with and without neurocognitive deficit: a 3-year longitudinal study
Ayesa Arriola, Rosa
Neuroanatomical
Neurocognition
Schizophrenia
Cognitive deficit
First-episode psychosis
title_short Neuroanatomical differences between first-episode psychosis patients with and without neurocognitive deficit: a 3-year longitudinal study
title_full Neuroanatomical differences between first-episode psychosis patients with and without neurocognitive deficit: a 3-year longitudinal study
title_fullStr Neuroanatomical differences between first-episode psychosis patients with and without neurocognitive deficit: a 3-year longitudinal study
title_full_unstemmed Neuroanatomical differences between first-episode psychosis patients with and without neurocognitive deficit: a 3-year longitudinal study
title_sort Neuroanatomical differences between first-episode psychosis patients with and without neurocognitive deficit: a 3-year longitudinal study
dc.creator.none.fl_str_mv Ayesa Arriola, Rosa
Roiz-Santiáñez, Roberto
Pérez-Iglesias, Rocío
Ferro, Adele
Sainz, Jesús
Crespo-Facorro, Benedicto
author Ayesa Arriola, Rosa
author_facet Ayesa Arriola, Rosa
Roiz-Santiáñez, Roberto
Pérez-Iglesias, Rocío
Ferro, Adele
Sainz, Jesús
Crespo-Facorro, Benedicto
author_role author
author2 Roiz-Santiáñez, Roberto
Pérez-Iglesias, Rocío
Ferro, Adele
Sainz, Jesús
Crespo-Facorro, Benedicto
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Universidad de Cantabria
Instituto de Investigación Marqués de Valdecilla
European Commission
Fundació Seny
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Neuroanatomical
Neurocognition
Schizophrenia
Cognitive deficit
First-episode psychosis
topic Neuroanatomical
Neurocognition
Schizophrenia
Cognitive deficit
First-episode psychosis
description This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY).
publishDate 2013
dc.date.none.fl_str_mv 2013
2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/130421
url http://hdl.handle.net/10261/130421
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3389/fpsyt.2013.00134
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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