Novel methods for the efficacy and safety in the artificial pancreas intended for domiciliary use
Type 1 diabetes (T1D) is an autoimmune disease that targets the insulin producing β-cells in the pancreas that results in chronically elevated blood glucose (BG) levels and requires lifelong insulin-replacement therapy. T1D results in many acute and chronic complications that reduce life quality, in...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/666975 |
| Acceso en línea: | http://hdl.handle.net/10803/666975 |
| Access Level: | acceso abierto |
| Palabra clave: | Artificial pancreas Pàncrees artificial Páncreas artificial Unscented Kalman Detection Detecció Detección Unannounced meals Àpats no anunciats Comidas no anunciadas Unannounced aerobic exercise Exercici aeròbic no anunciat Ejercicio aeróbico no anunciado Closed-loop control Control de llaç tancat Control de lazo cerrado Algorithm Algoritme Algoritmo Hyperglycemia Hiperglucèmia Hiperglucemia Hypoglycemia Hipoglucèmia Hipoglucemia 004 616.4 68 |
| Sumario: | Type 1 diabetes (T1D) is an autoimmune disease that targets the insulin producing β-cells in the pancreas that results in chronically elevated blood glucose (BG) levels and requires lifelong insulin-replacement therapy. T1D results in many acute and chronic complications that reduce life quality, increase economic burden, and increase the risk of mortality. A new methodology for the detection of disturbances, which involves the estimation of a disturbance state, D of an augmented minimal model determined using an Unscented Kalman Filter has been developed. The postprandial hyperglycemia reduction algorithm (PHRA) and the exercise-induced hypoglycemia reduction algorithm (EHRA) developed in this thesis include detection algorithms that trigger automatic disturbance rejection actions to safely and effectively mitigate postprandial hyerglycemia and hypoglycemia induced by aerobic exercise, respectively. The systems developed in this thesis are intended to be improved, extensively evaluated in silico, and then validated in future clinical trials |
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