Insulin resistance modulates iron-related proteins in adipose tissue

OBJECTIVE Circulating markers of iron overload are associated with insulin resistance. Less is known about the impact of iron overload on adipose tissue (AT). We hypothesized that gene expression markers of iron metabolism in AT could be associated with insulin action. RESEARCH DESIGN AND METHODS Th...

Descripción completa

Detalles Bibliográficos
Autores: Moreno Navarrete, José María, Garrido Novelle, Marta, Catalán, Victoria, Ortega Gómez, Francisco, Moreno, María, Gómez Ambrosi, Javier, Xifra, Gemma, Serrano, Marta, Guerra, Ester, Ricart, Wilfredo, Frühbeck, Gema, Diéguez, Carlos, Fernández Real, José Manuel
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/94877
Acceso en línea:https://hdl.handle.net/20.500.14352/94877
Access Level:acceso abierto
Palabra clave:577.17
Bioquímica (Biología)
2411.04 Fisiología Endocrina
2403 Bioquímica
Descripción
Sumario:OBJECTIVE Circulating markers of iron overload are associated with insulin resistance. Less is known about the impact of iron overload on adipose tissue (AT). We hypothesized that gene expression markers of iron metabolism in AT could be associated with insulin action. RESEARCH DESIGN AND METHODS The AT expression of ferroportin (SLC40A1), transferrin (TF), TF receptor (TFRC), ferritin (FT) heavy polypeptide 1 (FTH1), and FT light polypeptide (FTL) was analyzed cross-sectionally in three independent cohorts and also after weight loss–induced changes in insulin sensitivity (clamp M value) in an independent fourth cohort. RESULTS In human AT, TF mRNA and protein levels were decreased with obesity and insulin resistance in the three cohorts and were positively associated with adipogenic mRNAs and insulin action. Otherwise, FTL mRNA and protein and SLC40A1 transcripts were positively associated with BMI and negatively linked to adipogenic genes and insulin action. Bariatric surgery–induced weight loss led to increased TF and decreased TFRC, FTH1, FTL, and SLC40A1 in subcutaneous AT in parallel to improved insulin action. CONCLUSIONS These results suggest that iron overload impacts on AT in association with insulin resistance.

Similares en LA Referencia