Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion
Cell biology; Chemoresistance; Mucins
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:11351/7894 |
| Acceso en línea: | https://hdl.handle.net/11351/7894 http://hdl.handle.net/11351/7894 |
| Access Level: | acceso abierto |
| Palabra clave: | Còlon - Càncer - Fisiologia patològica Recte - Càncer - Fisiologia patològica DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms Other subheadings::Other subheadings::Other subheadings::/physiopathology ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales Otros calificadores::Otros calificadores::Otros calificadores::/fisiopatología |
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Reversing chemorefraction in colorectal cancer cells by controlling mucin secretionCantero Recasens, GerardAlonso-Marañón, JosuneLobo Jarne, TeresaGarrido, MartaIglesias, MarEspinosa, LluisMalhotra, VivekCòlon - Càncer - Fisiologia patològicaRecte - Càncer - Fisiologia patològicaDISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal NeoplasmsOther subheadings::Other subheadings::Other subheadings::/physiopathologyENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectalesOtros calificadores::Otros calificadores::Otros calificadores::/fisiopatologíaCell biology; Chemoresistance; MucinsBiología Celular; Quimiorresistencia; MucinasBiologia cel·lular; Quimioresistència; MucinesFifteen percent of colorectal cancer (CRC) cells exhibit a mucin hypersecretory phenotype, which is suggested to provide resistance to immune surveillance and chemotherapy. We now formally show that CRC cells build a barrier to chemotherapeutics by increasing mucins’ secretion. We show that low levels of KChIP3, a negative regulator of mucin secretion (Cantero-Recasens et al., 2018), is a risk factor for CRC patients’ relapse in a subset of untreated tumours. Our results also reveal that cells depleted of KChIP3 are four times more resistant (measured as cell viability and DNA damage) to chemotherapeutics 5-fluorouracil + irinotecan (5-FU+iri.) compared to control cells, whereas KChIP3-overexpressing cells are 10 times more sensitive to killing by chemotherapeutics. A similar increase in tumour cell death is observed upon chemical inhibition of mucin secretion by the sodium/calcium exchanger (NCX) blockers (Mitrovic et al., 2013). Finally, sensitivity of CRC patient-derived organoids to 5-FU+iri. increases 40-fold upon mucin secretion inhibition. Reducing mucin secretion thus provides a means to control chemoresistance of mucinous CRC cells and other mucinous tumours.eLife Sciences PublicationsInstitut Català de la Salut[Cantero-Recasens G] Grup de Recerca en Fisiopatologia Renal, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Alonso-Marañón J, Lobo-Jarne T, Garrido M, Espinosa L] Cancer Research Program, Institut Mar d'Investigacions Mèdiques, CIBERONC Hospital del Mar, Barcelona, Spain. [Iglesias M] Department of Pathologia, Institut Mar d'Investigacions Mèdiques, Universitat Autònoma de Barcelona, CIBERONC, Barcelona, Spain. [Malhotra V] Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7894http://hdl.handle.net/11351/7894Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)IngléseLife;11https://doi.org/10.7554/eLife.73926Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/78942026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion |
| title |
Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion |
| spellingShingle |
Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion Cantero Recasens, Gerard Còlon - Càncer - Fisiologia patològica Recte - Càncer - Fisiologia patològica DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms Other subheadings::Other subheadings::Other subheadings::/physiopathology ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales Otros calificadores::Otros calificadores::Otros calificadores::/fisiopatología |
| title_short |
Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion |
| title_full |
Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion |
| title_fullStr |
Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion |
| title_full_unstemmed |
Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion |
| title_sort |
Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion |
| dc.creator.none.fl_str_mv |
Cantero Recasens, Gerard Alonso-Marañón, Josune Lobo Jarne, Teresa Garrido, Marta Iglesias, Mar Espinosa, Lluis Malhotra, Vivek |
| author |
Cantero Recasens, Gerard |
| author_facet |
Cantero Recasens, Gerard Alonso-Marañón, Josune Lobo Jarne, Teresa Garrido, Marta Iglesias, Mar Espinosa, Lluis Malhotra, Vivek |
| author_role |
author |
| author2 |
Alonso-Marañón, Josune Lobo Jarne, Teresa Garrido, Marta Iglesias, Mar Espinosa, Lluis Malhotra, Vivek |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Cantero-Recasens G] Grup de Recerca en Fisiopatologia Renal, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Alonso-Marañón J, Lobo-Jarne T, Garrido M, Espinosa L] Cancer Research Program, Institut Mar d'Investigacions Mèdiques, CIBERONC Hospital del Mar, Barcelona, Spain. [Iglesias M] Department of Pathologia, Institut Mar d'Investigacions Mèdiques, Universitat Autònoma de Barcelona, CIBERONC, Barcelona, Spain. [Malhotra V] Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Còlon - Càncer - Fisiologia patològica Recte - Càncer - Fisiologia patològica DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms Other subheadings::Other subheadings::Other subheadings::/physiopathology ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales Otros calificadores::Otros calificadores::Otros calificadores::/fisiopatología |
| topic |
Còlon - Càncer - Fisiologia patològica Recte - Càncer - Fisiologia patològica DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms Other subheadings::Other subheadings::Other subheadings::/physiopathology ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales Otros calificadores::Otros calificadores::Otros calificadores::/fisiopatología |
| description |
Cell biology; Chemoresistance; Mucins |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022 2022 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/7894 http://hdl.handle.net/11351/7894 |
| url |
https://hdl.handle.net/11351/7894 http://hdl.handle.net/11351/7894 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
| dc.relation.none.fl_str_mv |
eLife;11 https://doi.org/10.7554/eLife.73926 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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eLife Sciences Publications |
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eLife Sciences Publications |
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Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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