Serum levels of autotaxin reveal its role as a novel biomarker of migraine

Migraine is the most common neurological disorder and the second most disabling human condition. Autotaxin (ATX) is a plasma enzyme that leads to the formation of lysophosphatidic acid (LPA), which is involved in different functions involved in migraine, such as vascular tone control, inflammation,...

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Detalles Bibliográficos
Autores: Ouro, Alberto, Castro-Mosquera, Mónica, Rodríguez-Arrizabalaga, Mariña, Debasa-Mouce, Manuel, Romaus-Sanjurjo, Daniel, Aramburu-Nuñez, Marta, Iglesias-Rey, Ramón, Casas, Josefina, Lema, Isabel, Castillo, José, Leira, Rogelio, Sobrino, Tomás
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/383991
Acceso en línea:http://hdl.handle.net/10261/383991
https://api.elsevier.com/content/abstract/scopus_id/86000259374
Access Level:acceso abierto
Palabra clave:Lysophospholipids
Autotaxin
Calcitonin gene‐related peptide
Endothelial dysfunction
Inflammation
Migraine
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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repository_id_str
spelling Serum levels of autotaxin reveal its role as a novel biomarker of migraineOuro, AlbertoCastro-Mosquera, MónicaRodríguez-Arrizabalaga, MariñaDebasa-Mouce, ManuelRomaus-Sanjurjo, DanielAramburu-Nuñez, MartaIglesias-Rey, RamónCasas, JosefinaLema, IsabelCastillo, JoséLeira, RogelioSobrino, TomásLysophospholipidsAutotaxinCalcitonin gene‐related peptideEndothelial dysfunctionInflammationMigrainehttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesMigraine is the most common neurological disorder and the second most disabling human condition. Autotaxin (ATX) is a plasma enzyme that leads to the formation of lysophosphatidic acid (LPA), which is involved in different functions involved in migraine, such as vascular tone control, inflammation, neuronal excitation, endothelial dysfunction, and neuropathic pain, among others. Most patients with migraine are females and, interestingly, ATX is physiologically higher in the serum of females compared to males.This study was partially supported by grants from the Xunta de Galicia (TS: IN607A2022/07), Instituto de Salud Carlos III (ISCIII) (Tomás Sobrino: PI22/00938 and Ramón Iglesias-Rey: CP22/00061) and CIBERNED (CB22/05/00067). This project has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement (number 101066444). Furthermore, this study was also supported by grants from the INTERREG Atlantic Area (EAPA_791/2018_NEUROATLANTIC project), INTER-REG V A España Portugal (POCTEP) (0624_2IQBIONEURO_6_E), and the European Regional Development Fund (ERDF). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the PhD manuscript.Peer reviewedWiley-VCH0000-0003-4359-1704Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/383991https://api.elsevier.com/content/abstract/scopus_id/86000259374reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésHeadachehttps://doi.org/10.1111/head.14922Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3839912026-05-22T06:33:51Z
dc.title.none.fl_str_mv Serum levels of autotaxin reveal its role as a novel biomarker of migraine
title Serum levels of autotaxin reveal its role as a novel biomarker of migraine
spellingShingle Serum levels of autotaxin reveal its role as a novel biomarker of migraine
Ouro, Alberto
Lysophospholipids
Autotaxin
Calcitonin gene‐related peptide
Endothelial dysfunction
Inflammation
Migraine
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Serum levels of autotaxin reveal its role as a novel biomarker of migraine
title_full Serum levels of autotaxin reveal its role as a novel biomarker of migraine
title_fullStr Serum levels of autotaxin reveal its role as a novel biomarker of migraine
title_full_unstemmed Serum levels of autotaxin reveal its role as a novel biomarker of migraine
title_sort Serum levels of autotaxin reveal its role as a novel biomarker of migraine
dc.creator.none.fl_str_mv Ouro, Alberto
Castro-Mosquera, Mónica
Rodríguez-Arrizabalaga, Mariña
Debasa-Mouce, Manuel
Romaus-Sanjurjo, Daniel
Aramburu-Nuñez, Marta
Iglesias-Rey, Ramón
Casas, Josefina
Lema, Isabel
Castillo, José
Leira, Rogelio
Sobrino, Tomás
author Ouro, Alberto
author_facet Ouro, Alberto
Castro-Mosquera, Mónica
Rodríguez-Arrizabalaga, Mariña
Debasa-Mouce, Manuel
Romaus-Sanjurjo, Daniel
Aramburu-Nuñez, Marta
Iglesias-Rey, Ramón
Casas, Josefina
Lema, Isabel
Castillo, José
Leira, Rogelio
Sobrino, Tomás
author_role author
author2 Castro-Mosquera, Mónica
Rodríguez-Arrizabalaga, Mariña
Debasa-Mouce, Manuel
Romaus-Sanjurjo, Daniel
Aramburu-Nuñez, Marta
Iglesias-Rey, Ramón
Casas, Josefina
Lema, Isabel
Castillo, José
Leira, Rogelio
Sobrino, Tomás
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv 0000-0003-4359-1704
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Lysophospholipids
Autotaxin
Calcitonin gene‐related peptide
Endothelial dysfunction
Inflammation
Migraine
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic Lysophospholipids
Autotaxin
Calcitonin gene‐related peptide
Endothelial dysfunction
Inflammation
Migraine
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description Migraine is the most common neurological disorder and the second most disabling human condition. Autotaxin (ATX) is a plasma enzyme that leads to the formation of lysophosphatidic acid (LPA), which is involved in different functions involved in migraine, such as vascular tone control, inflammation, neuronal excitation, endothelial dysfunction, and neuropathic pain, among others. Most patients with migraine are females and, interestingly, ATX is physiologically higher in the serum of females compared to males.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/383991
https://api.elsevier.com/content/abstract/scopus_id/86000259374
url http://hdl.handle.net/10261/383991
https://api.elsevier.com/content/abstract/scopus_id/86000259374
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Headache
https://doi.org/10.1111/head.14922
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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