Linking birth experience and perinatal depression symptoms to neuroanatomical changes in hippocampus and amygdala

Childbirth is a life-changing event in a mother's life. While the transition to motherhood has recently been recognized as one of the most neuroplastic periods in adulthood, no study has yet explored whether the hippocampus and amygdala change during the peripartum in relation to childbirth...

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Autores: Ballesteros, Cristina, Paternina-Die, María, Martínez-García, Magdalena, López Montoya, Gonzalo, Noguero, Inés, Desco, Manuel, Vilarroya, Óscar, Martín de Blas, Daniel, Carmona, Susanna
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
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Acesso em linha:https://hdl.handle.net/10230/73033
http://dx.doi.org/10.1126/sciadv.adt5619
Access Level:acceso abierto
Palavra-chave:Part--Ensenyament
Nucli amigdaloide
Depressió postpart
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spelling Linking birth experience and perinatal depression symptoms to neuroanatomical changes in hippocampus and amygdalaBallesteros, CristinaPaternina-Die, MaríaMartínez-García, MagdalenaLópez Montoya, GonzaloNoguero, InésDesco, ManuelVilarroya, ÓscarMartín de Blas, DanielCarmona, SusannaPart--EnsenyamentNucli amigdaloideDepressió postpartChildbirth is a life-changing event in a mother's life. While the transition to motherhood has recently been recognized as one of the most neuroplastic periods in adulthood, no study has yet explored whether the hippocampus and amygdala change during the peripartum in relation to childbirth experience and perinatal depression symptoms. In this longitudinal neuroimaging study, we assessed 88 first-time gestational mothers in late pregnancy and early postpartum and 30 nulliparous control women. We used optimized high-resolution MRI scans to quantify volumetric changes in the hippocampus and amygdala, along with their substructures. We found that increases in depression symptoms during the peripartum were positively correlated with changes in the right amygdala. A more challenging birth experience was associated with bilateral increases in hippocampal volume. These findings show that studying the neuroanatomical changes during the transition to motherhood can inform not only about adaptive processes but also about potential vulnerabilities, highlighting the importance of tracking perinatal experiences to enhance women's health.This work has been funded by Instituto de Salud Carlos III (ISCIII) through the project "PI22/01365" and cofunded by the European Union, the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 883069) and the Centro Nacional de Investigaciones Cardiovasculares (CNIC). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia, Innovación y Universidades (MICIU), and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIU/AEI/10.13039/501100011033). C.B. as funded by the grant Intramural Programme of IiSGM for the Promotion of R&D&I 2023, subprogram "Pre-doctoral training contract. S.C. was funded by Miguel Servet Type II research contract CPII21/00016 and co-funded by the European Social Fund" Investing in your future.American Association for the Advancement of Science (AAAS)2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10230/73033http://dx.doi.org/10.1126/sciadv.adt5619https://hdl.handle.net/10230/73033reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésScience advances. 2025 Mar 7;11(10):eadt5619info:eu-repo/grantAgreement/EC/H2020/883069Copyright © 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.Distributed under a Creative Commons Attribution NonCommercial License 4.0 (http://creativecommons.org/licenses/by-nc/4.0)http://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessoai:dnet:recercat____::e722be837aecbad33be26d64f39bd7d72026-05-29T05:05:01Z
dc.title.none.fl_str_mv Linking birth experience and perinatal depression symptoms to neuroanatomical changes in hippocampus and amygdala
title Linking birth experience and perinatal depression symptoms to neuroanatomical changes in hippocampus and amygdala
spellingShingle Linking birth experience and perinatal depression symptoms to neuroanatomical changes in hippocampus and amygdala
Ballesteros, Cristina
Part--Ensenyament
Nucli amigdaloide
Depressió postpart
title_short Linking birth experience and perinatal depression symptoms to neuroanatomical changes in hippocampus and amygdala
title_full Linking birth experience and perinatal depression symptoms to neuroanatomical changes in hippocampus and amygdala
title_fullStr Linking birth experience and perinatal depression symptoms to neuroanatomical changes in hippocampus and amygdala
title_full_unstemmed Linking birth experience and perinatal depression symptoms to neuroanatomical changes in hippocampus and amygdala
title_sort Linking birth experience and perinatal depression symptoms to neuroanatomical changes in hippocampus and amygdala
dc.creator.none.fl_str_mv Ballesteros, Cristina
Paternina-Die, María
Martínez-García, Magdalena
López Montoya, Gonzalo
Noguero, Inés
Desco, Manuel
Vilarroya, Óscar
Martín de Blas, Daniel
Carmona, Susanna
author Ballesteros, Cristina
author_facet Ballesteros, Cristina
Paternina-Die, María
Martínez-García, Magdalena
López Montoya, Gonzalo
Noguero, Inés
Desco, Manuel
Vilarroya, Óscar
Martín de Blas, Daniel
Carmona, Susanna
author_role author
author2 Paternina-Die, María
Martínez-García, Magdalena
López Montoya, Gonzalo
Noguero, Inés
Desco, Manuel
Vilarroya, Óscar
Martín de Blas, Daniel
Carmona, Susanna
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Part--Ensenyament
Nucli amigdaloide
Depressió postpart
topic Part--Ensenyament
Nucli amigdaloide
Depressió postpart
description Childbirth is a life-changing event in a mother's life. While the transition to motherhood has recently been recognized as one of the most neuroplastic periods in adulthood, no study has yet explored whether the hippocampus and amygdala change during the peripartum in relation to childbirth experience and perinatal depression symptoms. In this longitudinal neuroimaging study, we assessed 88 first-time gestational mothers in late pregnancy and early postpartum and 30 nulliparous control women. We used optimized high-resolution MRI scans to quantify volumetric changes in the hippocampus and amygdala, along with their substructures. We found that increases in depression symptoms during the peripartum were positively correlated with changes in the right amygdala. A more challenging birth experience was associated with bilateral increases in hippocampal volume. These findings show that studying the neuroanatomical changes during the transition to motherhood can inform not only about adaptive processes but also about potential vulnerabilities, highlighting the importance of tracking perinatal experiences to enhance women's health.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10230/73033
http://dx.doi.org/10.1126/sciadv.adt5619
https://hdl.handle.net/10230/73033
url https://hdl.handle.net/10230/73033
http://dx.doi.org/10.1126/sciadv.adt5619
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Science advances. 2025 Mar 7;11(10):eadt5619
info:eu-repo/grantAgreement/EC/H2020/883069
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association for the Advancement of Science (AAAS)
publisher.none.fl_str_mv American Association for the Advancement of Science (AAAS)
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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