Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictors

Few previous studies have focused on affective impairment after transient ischemic attack (TIA) and/or minor stroke. The aim was to establish the prevalence, evolution and predictors of post-stroke depression (PSD) and post-stroke apathy (PSA) over a 12-month follow-up period. We prospectively inclu...

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Autores: Carnes Vendrell, Anna, Deus Yela, Juan, Molina Seguin, Jessica, Pifarré Paredero, Josep, Purroy Garcia, Francisco
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/68322
Acceso en línea:https://doi.org/10.1038/s41598-019-52721-5
http://hdl.handle.net/10459.1/68322
Access Level:acceso abierto
Palabra clave:Depressió psíquica
Ansietat
Atac isquèmic transitori
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spelling Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and PredictorsCarnes Vendrell, AnnaDeus Yela, JuanMolina Seguin, JessicaPifarré Paredero, JosepPurroy Garcia, FranciscoDepressió psíquicaAnsietatAtac isquèmic transitoriFew previous studies have focused on affective impairment after transient ischemic attack (TIA) and/or minor stroke. The aim was to establish the prevalence, evolution and predictors of post-stroke depression (PSD) and post-stroke apathy (PSA) over a 12-month follow-up period. We prospectively included TIA and minor stroke patients (NIHSS ≤4) who had undergone magnetic resonance imaging <7 days. PSD was diagnosed according to DSM-5 criteria and PSA was defined based on an Apathy Evaluation Scale (AES-C) score of ≥37. Clinical and neuroimaging variables (presence and patterns of lesion, cerebral bleeds and white matter disease) were analysed in order to find potential predictors for PSD and PSA. Follow-up was performed at 10 days and after 2, 6, 9 and 12 months. 82 patients were included (mean 66.4 [standard deviation11.0] years) of whom 70 completed the follow-up. At 10 days, 36 (43.9%) and 28 (34.1%) patients respectively were diagnosed with PSD and PSA. At 12 months, 25 of 70 (35.7%) patients still had PSA, but only 6 of 70 (8.6%) had PSD. Beck Depression Inventory-II score, mini mental state examination (MMSE) and a previous history of depression or anxiety were predictors for PSD. While MMSE score, The Montgomery Asberg Depression Rating Scale and having previously suffered a stroke were also risk factors for PSA. Acute basal ganglia lesion and periventricular leukoaraiosis were associated with PSA while deep leukorariosis with PSD. Despite the presence of few or only transient symptoms, PSD and PSA frequent appear early after TIA and minor stroke. Unlike PSD, apathy tends to persist during follow-up.The Management Agency Responsible for University and Research Funding of the Catalan Administration participated in the organisation of the Research Group SGR 2017/1198 and SGR 2017/1628.Nature Research202020202019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1038/s41598-019-52721-5http://hdl.handle.net/10459.1/68322http://hdl.handle.net/10459.1/68322reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.1038/s41598-019-52721-5Scientific Reports, 2019, vol. 9, núm. 16248cc-by, (c) Carnes-Vendrell et al., 2019info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/683222026-05-29T05:05:01Z
dc.title.none.fl_str_mv Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictors
title Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictors
spellingShingle Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictors
Carnes Vendrell, Anna
Depressió psíquica
Ansietat
Atac isquèmic transitori
title_short Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictors
title_full Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictors
title_fullStr Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictors
title_full_unstemmed Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictors
title_sort Depression and Apathy After Transient Ischemic Attack or Minor Stroke: Prevalence, Evolution and Predictors
dc.creator.none.fl_str_mv Carnes Vendrell, Anna
Deus Yela, Juan
Molina Seguin, Jessica
Pifarré Paredero, Josep
Purroy Garcia, Francisco
author Carnes Vendrell, Anna
author_facet Carnes Vendrell, Anna
Deus Yela, Juan
Molina Seguin, Jessica
Pifarré Paredero, Josep
Purroy Garcia, Francisco
author_role author
author2 Deus Yela, Juan
Molina Seguin, Jessica
Pifarré Paredero, Josep
Purroy Garcia, Francisco
author2_role author
author
author
author
dc.subject.none.fl_str_mv Depressió psíquica
Ansietat
Atac isquèmic transitori
topic Depressió psíquica
Ansietat
Atac isquèmic transitori
description Few previous studies have focused on affective impairment after transient ischemic attack (TIA) and/or minor stroke. The aim was to establish the prevalence, evolution and predictors of post-stroke depression (PSD) and post-stroke apathy (PSA) over a 12-month follow-up period. We prospectively included TIA and minor stroke patients (NIHSS ≤4) who had undergone magnetic resonance imaging <7 days. PSD was diagnosed according to DSM-5 criteria and PSA was defined based on an Apathy Evaluation Scale (AES-C) score of ≥37. Clinical and neuroimaging variables (presence and patterns of lesion, cerebral bleeds and white matter disease) were analysed in order to find potential predictors for PSD and PSA. Follow-up was performed at 10 days and after 2, 6, 9 and 12 months. 82 patients were included (mean 66.4 [standard deviation11.0] years) of whom 70 completed the follow-up. At 10 days, 36 (43.9%) and 28 (34.1%) patients respectively were diagnosed with PSD and PSA. At 12 months, 25 of 70 (35.7%) patients still had PSA, but only 6 of 70 (8.6%) had PSD. Beck Depression Inventory-II score, mini mental state examination (MMSE) and a previous history of depression or anxiety were predictors for PSD. While MMSE score, The Montgomery Asberg Depression Rating Scale and having previously suffered a stroke were also risk factors for PSA. Acute basal ganglia lesion and periventricular leukoaraiosis were associated with PSA while deep leukorariosis with PSD. Despite the presence of few or only transient symptoms, PSD and PSA frequent appear early after TIA and minor stroke. Unlike PSD, apathy tends to persist during follow-up.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1038/s41598-019-52721-5
http://hdl.handle.net/10459.1/68322
http://hdl.handle.net/10459.1/68322
url https://doi.org/10.1038/s41598-019-52721-5
http://hdl.handle.net/10459.1/68322
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.1038/s41598-019-52721-5
Scientific Reports, 2019, vol. 9, núm. 16248
dc.rights.none.fl_str_mv cc-by, (c) Carnes-Vendrell et al., 2019
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by, (c) Carnes-Vendrell et al., 2019
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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