Predictors of cognitive decline in Alzheimer"s disease and mild cognitive impairment using the CAMCOG: a five-year follow-up

Background: There are discrepant findings regarding which subscales of the Cambridge Cognitive Examination(CAMCOG) are able to predict cognitive decline. The study aimed to identify the baseline CAMCOG subscales that can discriminate between patients and predict cognitive decline in Alzheimer"s...

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Autores: Conde Sala, Josep Lluís, Garre Olmo, Josep, Vilalta Franch, Joan, Llinàs Reglà, Jordi, Turró-Garriga, Oriol, Lozano Gallego, Manuela, Hernández-Ferrándiz, Marta, Pericot Nierga, Imma, López Pousa, Secundino
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/56387
Acceso en línea:https://hdl.handle.net/2445/56387
Access Level:acceso abierto
Palabra clave:Factors de risc en les malalties
Demència senil
Envelliment
Memòria
Risk factors in diseases
Senile dementia
Aging
Memory
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spelling Predictors of cognitive decline in Alzheimer"s disease and mild cognitive impairment using the CAMCOG: a five-year follow-upConde Sala, Josep LluísGarre Olmo, JosepVilalta Franch, JoanLlinàs Reglà, JordiTurró-Garriga, OriolLozano Gallego, ManuelaHernández-Ferrándiz, MartaPericot Nierga, ImmaLópez Pousa, SecundinoFactors de risc en les malaltiesDemència senilEnvellimentMemòriaRisk factors in diseasesSenile dementiaAgingMemoryBackground: There are discrepant findings regarding which subscales of the Cambridge Cognitive Examination(CAMCOG) are able to predict cognitive decline. The study aimed to identify the baseline CAMCOG subscales that can discriminate between patients and predict cognitive decline in Alzheimer"s disease (AD)and mild cognitive impairment (MCI). Methods: This was a five-year case-control study of patients with cognitive impairment and a control group.Participants were grouped into AD (n = 121), MCI converted to dementia (MCI-Ad, n = 43), MCI-stable(MCI-St, n = 66), and controls (CTR, n = 112). Differences in the mean scores obtained by the four groupswere examined. Receiver operating characteristic curves were used to compare subscale scores in the AD and MCI-Ad groups with those of controls. The influence of age, gender, schooling, and depression on baseline subscale scores was assessed. Results: Of the CAMCOG subscales, Orientation and Memory (learning and recent) (OR + MEM) showed the highest discriminant capacity in the baseline analysis of the four groups. This baseline analysis indicated that OR + MEM was the best predictor of conversion to AD in the MCI-Ad group (area under the curve, AUC = 0.81), whereas the predictive capacity of the global MMSE and CAMCOG scores was poor (AUC = 0.59 and 0.53, respectively). Conclusions: In the baseline analysis, the Orientation and Memory (learning and recent) subscales showed the highest discriminant and predictive capacity as regards both cognitive decline in the AD group and conversion to AD among MCI-Ad patients. This was not affected by age, gender, schooling, or depression.Cambridge University Press2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/56387Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: doi:10.1017/S1041610211002158International Psychogeriatrics, 2012, vol. 24, num. 6, p. 948-958http://dx.doi.org/10.1017/S1041610211002158(c) Cambridge University Press, 2012info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/563872026-05-27T06:46:51Z
dc.title.none.fl_str_mv Predictors of cognitive decline in Alzheimer"s disease and mild cognitive impairment using the CAMCOG: a five-year follow-up
title Predictors of cognitive decline in Alzheimer"s disease and mild cognitive impairment using the CAMCOG: a five-year follow-up
spellingShingle Predictors of cognitive decline in Alzheimer"s disease and mild cognitive impairment using the CAMCOG: a five-year follow-up
Conde Sala, Josep Lluís
Factors de risc en les malalties
Demència senil
Envelliment
Memòria
Risk factors in diseases
Senile dementia
Aging
Memory
title_short Predictors of cognitive decline in Alzheimer"s disease and mild cognitive impairment using the CAMCOG: a five-year follow-up
title_full Predictors of cognitive decline in Alzheimer"s disease and mild cognitive impairment using the CAMCOG: a five-year follow-up
title_fullStr Predictors of cognitive decline in Alzheimer"s disease and mild cognitive impairment using the CAMCOG: a five-year follow-up
title_full_unstemmed Predictors of cognitive decline in Alzheimer"s disease and mild cognitive impairment using the CAMCOG: a five-year follow-up
title_sort Predictors of cognitive decline in Alzheimer"s disease and mild cognitive impairment using the CAMCOG: a five-year follow-up
dc.creator.none.fl_str_mv Conde Sala, Josep Lluís
Garre Olmo, Josep
Vilalta Franch, Joan
Llinàs Reglà, Jordi
Turró-Garriga, Oriol
Lozano Gallego, Manuela
Hernández-Ferrándiz, Marta
Pericot Nierga, Imma
López Pousa, Secundino
author Conde Sala, Josep Lluís
author_facet Conde Sala, Josep Lluís
Garre Olmo, Josep
Vilalta Franch, Joan
Llinàs Reglà, Jordi
Turró-Garriga, Oriol
Lozano Gallego, Manuela
Hernández-Ferrándiz, Marta
Pericot Nierga, Imma
López Pousa, Secundino
author_role author
author2 Garre Olmo, Josep
Vilalta Franch, Joan
Llinàs Reglà, Jordi
Turró-Garriga, Oriol
Lozano Gallego, Manuela
Hernández-Ferrándiz, Marta
Pericot Nierga, Imma
López Pousa, Secundino
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Factors de risc en les malalties
Demència senil
Envelliment
Memòria
Risk factors in diseases
Senile dementia
Aging
Memory
topic Factors de risc en les malalties
Demència senil
Envelliment
Memòria
Risk factors in diseases
Senile dementia
Aging
Memory
description Background: There are discrepant findings regarding which subscales of the Cambridge Cognitive Examination(CAMCOG) are able to predict cognitive decline. The study aimed to identify the baseline CAMCOG subscales that can discriminate between patients and predict cognitive decline in Alzheimer"s disease (AD)and mild cognitive impairment (MCI). Methods: This was a five-year case-control study of patients with cognitive impairment and a control group.Participants were grouped into AD (n = 121), MCI converted to dementia (MCI-Ad, n = 43), MCI-stable(MCI-St, n = 66), and controls (CTR, n = 112). Differences in the mean scores obtained by the four groupswere examined. Receiver operating characteristic curves were used to compare subscale scores in the AD and MCI-Ad groups with those of controls. The influence of age, gender, schooling, and depression on baseline subscale scores was assessed. Results: Of the CAMCOG subscales, Orientation and Memory (learning and recent) (OR + MEM) showed the highest discriminant capacity in the baseline analysis of the four groups. This baseline analysis indicated that OR + MEM was the best predictor of conversion to AD in the MCI-Ad group (area under the curve, AUC = 0.81), whereas the predictive capacity of the global MMSE and CAMCOG scores was poor (AUC = 0.59 and 0.53, respectively). Conclusions: In the baseline analysis, the Orientation and Memory (learning and recent) subscales showed the highest discriminant and predictive capacity as regards both cognitive decline in the AD group and conversion to AD among MCI-Ad patients. This was not affected by age, gender, schooling, or depression.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/56387
url https://hdl.handle.net/2445/56387
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: doi:10.1017/S1041610211002158
International Psychogeriatrics, 2012, vol. 24, num. 6, p. 948-958
http://dx.doi.org/10.1017/S1041610211002158
dc.rights.none.fl_str_mv (c) Cambridge University Press, 2012
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Cambridge University Press, 2012
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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