Synthesis and impact of neuroestradiol on hippocampal neuronal networks

The production of estradiol within the brain, that is, neuroestradiol (nE2), is widely documented. nE2 deeply impacts adult brain physiology and synaptic plasticity. In the hippocampus, a region of the brain essential for cognitive function, multiple cellular sources, and targets of nE2 have been id...

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Detalhes bibliográficos
Autores: Azcoitia Elías, Iñigo, Hernández Vivanco, Alicia, Cano Adamuz, Nuria, Méndez, Pablo
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/71509
Acesso em linha:https://hdl.handle.net/20.500.14352/71509
Access Level:acceso abierto
Palavra-chave:577.17
612.8
Aromatase
Excitatory neurons
Estradiol
Estrogen
Hippocampus
Inhibitory neurons
Neurosteroids
Bioquímica (Biología)
Neurociencias (Biológicas)
2302 Bioquímica
2490 Neurociencias
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oai_identifier_str oai:docta.ucm.es:20.500.14352/71509
network_acronym_str ES
network_name_str España
repository_id_str
spelling Synthesis and impact of neuroestradiol on hippocampal neuronal networksAzcoitia Elías, IñigoHernández Vivanco, AliciaCano Adamuz, NuriaMéndez, Pablo577.17612.8AromataseExcitatory neuronsEstradiolEstrogenHippocampusInhibitory neuronsNeurosteroidsBioquímica (Biología)Neurociencias (Biológicas)2302 Bioquímica2490 NeurocienciasThe production of estradiol within the brain, that is, neuroestradiol (nE2), is widely documented. nE2 deeply impacts adult brain physiology and synaptic plasticity. In the hippocampus, a region of the brain essential for cognitive function, multiple cellular sources, and targets of nE2 have been identified. The impact of estradiol in excitatory and inhibitory neurotransmission suggests a role for regulated nE2 synthesis in the coordination of the activity of different cellular elements of hippocampal network. Here, we review the role of nE2 in the physiology of the hippocampal circuits taking into account the cellular heterogeneity of the hippocampus. We aspire at expanding the consideration of neuron-derived estradiol as a neuromodulator of hippocampal network activities underlying cognition.ElsevierUniversidad Complutense de Madrid20222022-02-2020222022-02-20journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/71509reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 3.0 Españahttps://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/715092026-06-02T12:44:21Z
dc.title.none.fl_str_mv Synthesis and impact of neuroestradiol on hippocampal neuronal networks
title Synthesis and impact of neuroestradiol on hippocampal neuronal networks
spellingShingle Synthesis and impact of neuroestradiol on hippocampal neuronal networks
Azcoitia Elías, Iñigo
577.17
612.8
Aromatase
Excitatory neurons
Estradiol
Estrogen
Hippocampus
Inhibitory neurons
Neurosteroids
Bioquímica (Biología)
Neurociencias (Biológicas)
2302 Bioquímica
2490 Neurociencias
title_short Synthesis and impact of neuroestradiol on hippocampal neuronal networks
title_full Synthesis and impact of neuroestradiol on hippocampal neuronal networks
title_fullStr Synthesis and impact of neuroestradiol on hippocampal neuronal networks
title_full_unstemmed Synthesis and impact of neuroestradiol on hippocampal neuronal networks
title_sort Synthesis and impact of neuroestradiol on hippocampal neuronal networks
dc.creator.none.fl_str_mv Azcoitia Elías, Iñigo
Hernández Vivanco, Alicia
Cano Adamuz, Nuria
Méndez, Pablo
author Azcoitia Elías, Iñigo
author_facet Azcoitia Elías, Iñigo
Hernández Vivanco, Alicia
Cano Adamuz, Nuria
Méndez, Pablo
author_role author
author2 Hernández Vivanco, Alicia
Cano Adamuz, Nuria
Méndez, Pablo
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 577.17
612.8
Aromatase
Excitatory neurons
Estradiol
Estrogen
Hippocampus
Inhibitory neurons
Neurosteroids
Bioquímica (Biología)
Neurociencias (Biológicas)
2302 Bioquímica
2490 Neurociencias
topic 577.17
612.8
Aromatase
Excitatory neurons
Estradiol
Estrogen
Hippocampus
Inhibitory neurons
Neurosteroids
Bioquímica (Biología)
Neurociencias (Biológicas)
2302 Bioquímica
2490 Neurociencias
description The production of estradiol within the brain, that is, neuroestradiol (nE2), is widely documented. nE2 deeply impacts adult brain physiology and synaptic plasticity. In the hippocampus, a region of the brain essential for cognitive function, multiple cellular sources, and targets of nE2 have been identified. The impact of estradiol in excitatory and inhibitory neurotransmission suggests a role for regulated nE2 synthesis in the coordination of the activity of different cellular elements of hippocampal network. Here, we review the role of nE2 in the physiology of the hippocampal circuits taking into account the cellular heterogeneity of the hippocampus. We aspire at expanding the consideration of neuron-derived estradiol as a neuromodulator of hippocampal network activities underlying cognition.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-02-20
2022
2022-02-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/71509
url https://hdl.handle.net/20.500.14352/71509
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
https://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
https://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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