CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS

Multiple sclerosis; SERPINA3

Bibliographic Details
Authors: Matute Blanch, Clara, Osman, Mohamoud, Costa Riu, Carme, Pinteac, Rucsanda, Miró Cau, Berta, Sánchez Pla, Alex, Brito, Veronica Ines, Montalban Gairín, Xavier, Comabella Lopez, Manuel, Fissolo, Nicolás Miguel
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/7703
Online Access:https://hdl.handle.net/11351/7703
Access Level:Open access
Keyword:Marcadors bioquímics
Esclerosi múltiple - Diagnòstic
Enzims proteolítics - Inhibidors
DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis::Multiple Sclerosis, Chronic Progressive
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Serpins
CHEMICALS AND DRUGS::Biological Factors::Biomarkers
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple::esclerosis múltiple crónica progresiva
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::serpinas
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores
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network_name_str España
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dc.title.none.fl_str_mv CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS
title CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS
spellingShingle CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS
Matute Blanch, Clara
Marcadors bioquímics
Esclerosi múltiple - Diagnòstic
Enzims proteolítics - Inhibidors
DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis::Multiple Sclerosis, Chronic Progressive
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Serpins
CHEMICALS AND DRUGS::Biological Factors::Biomarkers
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple::esclerosis múltiple crónica progresiva
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::serpinas
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores
title_short CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS
title_full CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS
title_fullStr CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS
title_full_unstemmed CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS
title_sort CSF SERPINA3 Levels Are Elevated in Patients With Progressive MS
dc.creator.none.fl_str_mv Matute Blanch, Clara
Osman, Mohamoud
Costa Riu, Carme
Pinteac, Rucsanda
Miró Cau, Berta
Sánchez Pla, Alex
Brito, Veronica Ines
Montalban Gairín, Xavier
Comabella Lopez, Manuel
Fissolo, Nicolás Miguel
author Matute Blanch, Clara
author_facet Matute Blanch, Clara
Osman, Mohamoud
Costa Riu, Carme
Pinteac, Rucsanda
Miró Cau, Berta
Sánchez Pla, Alex
Brito, Veronica Ines
Montalban Gairín, Xavier
Comabella Lopez, Manuel
Fissolo, Nicolás Miguel
author_role author
author2 Osman, Mohamoud
Costa Riu, Carme
Pinteac, Rucsanda
Miró Cau, Berta
Sánchez Pla, Alex
Brito, Veronica Ines
Montalban Gairín, Xavier
Comabella Lopez, Manuel
Fissolo, Nicolás Miguel
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Fissolo N, Matute-Blanch C, Costa C, Pinteac R, Brito V, Comabella Lopez M] Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Osman M] Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark. [Miró B] Unitat d'Estadística i Bioinformàtica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Sanchez A] Unitat d'Estadística i Bioinformàtica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Genetics, Microbiology and Statistics Department, Universitat de Barcelona, Spain. [Montalban X] Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Center for Multiple Sclerosis, St. Michael’s Hospital, University of Toronto, ON, Canada
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Marcadors bioquímics
Esclerosi múltiple - Diagnòstic
Enzims proteolítics - Inhibidors
DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis::Multiple Sclerosis, Chronic Progressive
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Serpins
CHEMICALS AND DRUGS::Biological Factors::Biomarkers
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple::esclerosis múltiple crónica progresiva
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::serpinas
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores
topic Marcadors bioquímics
Esclerosi múltiple - Diagnòstic
Enzims proteolítics - Inhibidors
DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis::Multiple Sclerosis, Chronic Progressive
CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Serpins
CHEMICALS AND DRUGS::Biological Factors::Biomarkers
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple::esclerosis múltiple crónica progresiva
COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::serpinas
COMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadores
description Multiple sclerosis; SERPINA3
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7703
url https://hdl.handle.net/11351/7703
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Neurology neuroimmunology & neuroinflammation.;8(2)
https://doi.org/10.1212/NXI.0000000000000941
info:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0015%2F0004
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer Health
publisher.none.fl_str_mv Wolters Kluwer Health
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling CSF SERPINA3 Levels Are Elevated in Patients With Progressive MSMatute Blanch, ClaraOsman, MohamoudCosta Riu, CarmePinteac, RucsandaMiró Cau, BertaSánchez Pla, AlexBrito, Veronica InesMontalban Gairín, XavierComabella Lopez, ManuelFissolo, Nicolás MiguelMarcadors bioquímicsEsclerosi múltiple - DiagnòsticEnzims proteolítics - InhibidorsDISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis::Multiple Sclerosis, Chronic ProgressiveCHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::SerpinsCHEMICALS AND DRUGS::Biological Factors::BiomarkersENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple::esclerosis múltiple crónica progresivaCOMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::serpinasCOMPUESTOS QUÍMICOS Y DROGAS::factores biológicos::biomarcadoresMultiple sclerosis; SERPINA3Esclerosi múltiple; SERPINA3Esclerosis múltiple; SERPINA3Objective To identify biomarkers associated with progressive phases of MS and with neuroprotective potential. Methods Combined analysis of the transcriptional and proteomic profiles obtained in CNS tissue during chronic progressive phases of experimental autoimmune encephalomyelitis (EAE) with the transcriptional profile obtained during the differentiation of murine neural stem cells into neurons. Candidate biomarkers were measured by ELISA in the CSF of 65 patients with MS (29 with relapsing-remitting MS [RRMS], 20 with secondary progressive MS, and 16 with primary progressive MS [PPMS]) and 30 noninflammatory neurologic controls (NINCs). Results Integrative analysis of gene and protein expression data identified 2 biomarkers, the serine protease inhibitor Serpina3n and the calcium-binding protein S100A4, which were upregulated in chronic progressive EAE and whose expression was induced during neuronal differentiation. Immunofluorescence studies revealed a primarily neuronal expression of S100A4 and Serpina3n during EAE. CSF levels of SERPINA3, the human ortholog of murine Serpina3n, and S100A4 were increased in patients with MS compared with NINCs (SERPINA3: 1,320 vs 838.6 ng/mL, p = 0.0001; S100A4: 1.6 vs 0.8 ng/mL, p = 0.02). Within the MS group, CSF SERPINA3 levels were significantly elevated in patients with progressive forms, mainly patients with PPMS compared with patients with RRMS (1,617 vs 1,129 ng/mL, p = 0.02) and NINCs (1,617 vs 838.6 ng/mL, p = 0.0001). Of interest, CSF SERPINA3 levels significantly correlated with CSF neurofilament light chain levels only in the PPMS group (r = 0.62, p = 0.01). Conclusion These results point to a role of SERPINA3 as a biomarker associated with the progressive forms of MS, particularly PPMS.This work was supported by grants from the Fondo de Investigación Sanitaria (FIS; grant number PI17/00596), Ministry of Science and Innovation, Spain; Generalitat de Catalunya Suport Grups de Recerca (2017 SGR 0527); and the Red Española de Esclerosis Múltiple (RD16/0015/0004) funded by the FIS.Wolters Kluwer HealthInstitut Català de la Salut[Fissolo N, Matute-Blanch C, Costa C, Pinteac R, Brito V, Comabella Lopez M] Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Osman M] Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark. [Miró B] Unitat d'Estadística i Bioinformàtica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Sanchez A] Unitat d'Estadística i Bioinformàtica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Genetics, Microbiology and Statistics Department, Universitat de Barcelona, Spain. [Montalban X] Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Center for Multiple Sclerosis, St. Michael’s Hospital, University of Toronto, ON, CanadaVall d'Hebron Barcelona Hospital Campus202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7703Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésNeurology neuroimmunology & neuroinflammation.;8(2)https://doi.org/10.1212/NXI.0000000000000941info:eu-repo/grantAgreement/ES/PE2013-2016/RD16%2F0015%2F0004Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/77032026-05-29T05:05:01Z
score 15.812429

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