Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense.

Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysacchar...

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Detalles Bibliográficos
Autores: Bosch, Marta, Sanchez-Alvarez, Miguel, Fajardo, Alba, Kapetanovic, Ronan, Steiner, Bernhard, Dutra, Filipe, Moreira, Luciana, Lopez, Juan Antonio, Campo, Marí, Montserrat, Morales-Paytuví, Frederic, Tort, Olivia, Gubern, Albert, Templin, Rachel M, Curson, James E B, Martel, Nick, Català, Cristina, Lozano, Francisco, Tebar, Francesc, Enrich, Carlos, Vazquez, Jesus, del Pozo, Miguel Angel, Sweet, Matthew J, Bozza, Patricia T, Gross, Steven P, Parton, Robert G, Pol, Albert
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/11240
Acceso en línea:http://hdl.handle.net/20.500.12105/11240
Access Level:acceso abierto
Palabra clave:Immunity, Innate
Animals
Antimicrobial Cationic Peptides
Bacteria
Fatty Acids
GTP Phosphohydrolases
HEK293 Cells
Host-Pathogen Interactions
Humans
Lipid Droplets
Lipopolysaccharides
Macrophages
Male
Mice
Mice, Inbred C57BL
Mitochondria
Descripción
Sumario:Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD-bacterial contacts. Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune proteins to kill intracellular pathogens as well as central players in the local and systemic metabolic adaptation to infection.

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