Nasal spray formulations based on combined hyalurosomes and glycerosomes loading Zingiber officinalis extract as green and natural strategy for the treatment of rhinitis and rhinosinusitis

8 figures, 3 tables.

Detalhes bibliográficos
Autores: Casula, Eleonora, Manca, Maria Letizia, Perra, Matteo, Pedraz, José Luís, López-Méndez, Tania Belén, Lozano Fantoba, Antonio, Calvo, Esteban, Zaru, Marco, Manconi, Maria
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/311499
Acesso em linha:http://hdl.handle.net/10261/311499
Access Level:acceso abierto
Palavra-chave:Zingiber officinalis
Traditional medicine
Phospholipid vesicles
Antioxidant
Epithelial cells
Nasal spray
Spray angle
Droplet size
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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spelling Nasal spray formulations based on combined hyalurosomes and glycerosomes loading Zingiber officinalis extract as green and natural strategy for the treatment of rhinitis and rhinosinusitisCasula, EleonoraManca, Maria LetiziaPerra, MatteoPedraz, José LuísLópez-Méndez, Tania BelénLozano Fantoba, AntonioCalvo, EstebanZaru, MarcoManconi, MariaZingiber officinalisTraditional medicinePhospholipid vesiclesAntioxidantEpithelial cellsNasal spraySpray angleDroplet sizehttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all ages8 figures, 3 tables.A total green nanotechnological nasal spray has been manufactured and proposed as an alternative treatment of rhinitis and rhinosinusitis. It was obtained by combining the strengthening effect of liposomes on barrier function, the hydrating and lubricating properties of sodium hyaluronan and the anti-inflammatory and antioxidant activities of the extract of Zingiber officinalis. To this purpose, the extract was loaded in special phospholipid vesicles immobilized with hyaluronic acid (hyalurosomes), which were further enriched with glycerol in the water phase. Liposomes and glycerosomes were prepared as well and used as reference. Vesicles were oligolamellar and multicompartment, as confirmed by cryogenic transmission electron microscopy (cryo-TEM) observation, small in size (~140 nm) and negatively charged (~−23 mV). Spray characteristics were evaluated by using the Spraytec® and instant images, from which the plume angle was measured. The range of the droplet size distribution and the narrow spray angle obtained suggest a good nebulization and a possible local deposition in the nasal cavity. In vitro studies performed by using human keratinocytes confirmed the high biocompatibility of vesicles and their ability to effectively counteract oxidative damage on cells induced by hydrogen peroxide. The overall collected data suggest that our vesicles are suitable as nasal spray.Peer reviewedMultidisciplinary Digital Publishing InstituteCasula, Eleonora [0000-0002-2031-4010]Manca, Maria Letizia [0000-0002-3787-257X]Perra, Matteo [0000-0002-9906-990X]Pedraz, José Luís [0000-0002-9566-8403]López-Méndez, Tania Belén [0000-0001-5029-6549]Lozano Fantoba, Antonio [0000-0003-4141-6072]Calvo, Esteban [0000-0002-5631-1401]Manconi, Maria [0000-0003-4818-2344]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/311499reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3390/antiox10071109Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3114992026-05-22T06:33:51Z
dc.title.none.fl_str_mv Nasal spray formulations based on combined hyalurosomes and glycerosomes loading Zingiber officinalis extract as green and natural strategy for the treatment of rhinitis and rhinosinusitis
title Nasal spray formulations based on combined hyalurosomes and glycerosomes loading Zingiber officinalis extract as green and natural strategy for the treatment of rhinitis and rhinosinusitis
spellingShingle Nasal spray formulations based on combined hyalurosomes and glycerosomes loading Zingiber officinalis extract as green and natural strategy for the treatment of rhinitis and rhinosinusitis
Casula, Eleonora
Zingiber officinalis
Traditional medicine
Phospholipid vesicles
Antioxidant
Epithelial cells
Nasal spray
Spray angle
Droplet size
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Nasal spray formulations based on combined hyalurosomes and glycerosomes loading Zingiber officinalis extract as green and natural strategy for the treatment of rhinitis and rhinosinusitis
title_full Nasal spray formulations based on combined hyalurosomes and glycerosomes loading Zingiber officinalis extract as green and natural strategy for the treatment of rhinitis and rhinosinusitis
title_fullStr Nasal spray formulations based on combined hyalurosomes and glycerosomes loading Zingiber officinalis extract as green and natural strategy for the treatment of rhinitis and rhinosinusitis
title_full_unstemmed Nasal spray formulations based on combined hyalurosomes and glycerosomes loading Zingiber officinalis extract as green and natural strategy for the treatment of rhinitis and rhinosinusitis
title_sort Nasal spray formulations based on combined hyalurosomes and glycerosomes loading Zingiber officinalis extract as green and natural strategy for the treatment of rhinitis and rhinosinusitis
dc.creator.none.fl_str_mv Casula, Eleonora
Manca, Maria Letizia
Perra, Matteo
Pedraz, José Luís
López-Méndez, Tania Belén
Lozano Fantoba, Antonio
Calvo, Esteban
Zaru, Marco
Manconi, Maria
author Casula, Eleonora
author_facet Casula, Eleonora
Manca, Maria Letizia
Perra, Matteo
Pedraz, José Luís
López-Méndez, Tania Belén
Lozano Fantoba, Antonio
Calvo, Esteban
Zaru, Marco
Manconi, Maria
author_role author
author2 Manca, Maria Letizia
Perra, Matteo
Pedraz, José Luís
López-Méndez, Tania Belén
Lozano Fantoba, Antonio
Calvo, Esteban
Zaru, Marco
Manconi, Maria
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Casula, Eleonora [0000-0002-2031-4010]
Manca, Maria Letizia [0000-0002-3787-257X]
Perra, Matteo [0000-0002-9906-990X]
Pedraz, José Luís [0000-0002-9566-8403]
López-Méndez, Tania Belén [0000-0001-5029-6549]
Lozano Fantoba, Antonio [0000-0003-4141-6072]
Calvo, Esteban [0000-0002-5631-1401]
Manconi, Maria [0000-0003-4818-2344]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Zingiber officinalis
Traditional medicine
Phospholipid vesicles
Antioxidant
Epithelial cells
Nasal spray
Spray angle
Droplet size
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic Zingiber officinalis
Traditional medicine
Phospholipid vesicles
Antioxidant
Epithelial cells
Nasal spray
Spray angle
Droplet size
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description 8 figures, 3 tables.
publishDate 2021
dc.date.none.fl_str_mv 2021
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/311499
url http://hdl.handle.net/10261/311499
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3390/antiox10071109
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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