Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol

Introduction: Age-related health, brain, and cognitive impairment is a great challenge in current society. Cognitive training, aerobic exercise and their combination have been shown to benefit health, brain, cognition and psychological status in healthy older adults. Inconsistent results across stud...

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Autores: Castells-Sánchez A, Roig-Coll F, Lamonja-Vicente N, Altés-Magret M, Torán-Monserrat P, Via M, García-Molina A, Tormos JM, Heras A, Alzamora MT, Forés R, Pera G, Dacosta-Aguayo R, Soriano-Raya JJ, Cáceres C, Montero-Alía P, Montero-Alía JJ, Jimenez-Gonzalez MM, Hernández-Pérez M, Perera-Lluna A, Grove GA, Munuera J, Domènech S, Erickson KI, Mataró M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p16577
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16577
https://www.frontiersin.org/articles/10.3389/fnagi.2019.00216/full
Access Level:acceso abierto
Palabra clave:computer-based cognitive training
aerobic exercise
neuroplasticity
neuroimaging
biomarkers
physically inactive
aging
fitness
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spelling Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment ProtocolCastells-Sánchez ARoig-Coll FLamonja-Vicente NAltés-Magret MTorán-Monserrat PVia MGarcía-Molina ATormos JMHeras AAlzamora MTForés RPera GDacosta-Aguayo RSoriano-Raya JJCáceres CMontero-Alía PMontero-Alía JJJimenez-Gonzalez MMHernández-Pérez MPerera-Lluna AGrove GAMunuera JDomènech SErickson KIMataró Mcomputer-based cognitive trainingaerobic exerciseneuroplasticityneuroimagingbiomarkersphysically inactiveagingfitnessIntroduction: Age-related health, brain, and cognitive impairment is a great challenge in current society. Cognitive training, aerobic exercise and their combination have been shown to benefit health, brain, cognition and psychological status in healthy older adults. Inconsistent results across studies may be related to several variables. We need to better identify cognitive changes, individual variables that may predict the effect of these interventions, and changes in structural and functional brain outcomes as well as physiological molecular correlates that may be mediating these effects. Projecte Moviment is a multi-domain randomized trial examining the effect of these interventions applied 5 days per week for 3 months compared to a passive control group. The aim of this paper is to describe the sample, procedures and planned analyses. Methods: One hundred and forty healthy physically inactive older adults will be randomly assigned to computerized cognitive training (COT), aerobic exercise (AE), combined training (COMB), or a control group. The intervention consists of a 3 month home-based program 5 days per week in sessions of 45 min. Data from cognitive, physical, and psychological tests, cardiovascular risk factors, structural and functional brain scans, and blood samples will be obtained before and after the intervention. Results: Effects of the interventions on cognitive outcomes will be described in intention-to-treat and per protocol analyses. We will also analyze potential genetic, demographic, brain, and physiological molecular correlates that may predict the effects of intervention, as well as the association between cognitive effects and changes in these variables using the per protocol sample. Discussion: Projecte Moviment is a multi-domain intervention trial based on prior evidence that aims to understand the effects of CCT, AE, and COMB on cognitive and psychological outcomes compared to a passive control group, and to determine related biological correlates and predictors of the intervention effects.FRONTIERS MEDIA SA2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16577https://www.frontiersin.org/articles/10.3389/fnagi.2019.00216/fullFrontiers in Aging NeuroscienceISSN: 16634365reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p165772026-05-27T12:37:41Z
dc.title.none.fl_str_mv Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
title Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
spellingShingle Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
Castells-Sánchez A
computer-based cognitive training
aerobic exercise
neuroplasticity
neuroimaging
biomarkers
physically inactive
aging
fitness
title_short Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
title_full Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
title_fullStr Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
title_full_unstemmed Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
title_sort Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
dc.creator.none.fl_str_mv Castells-Sánchez A
Roig-Coll F
Lamonja-Vicente N
Altés-Magret M
Torán-Monserrat P
Via M
García-Molina A
Tormos JM
Heras A
Alzamora MT
Forés R
Pera G
Dacosta-Aguayo R
Soriano-Raya JJ
Cáceres C
Montero-Alía P
Montero-Alía JJ
Jimenez-Gonzalez MM
Hernández-Pérez M
Perera-Lluna A
Grove GA
Munuera J
Domènech S
Erickson KI
Mataró M
author Castells-Sánchez A
author_facet Castells-Sánchez A
Roig-Coll F
Lamonja-Vicente N
Altés-Magret M
Torán-Monserrat P
Via M
García-Molina A
Tormos JM
Heras A
Alzamora MT
Forés R
Pera G
Dacosta-Aguayo R
Soriano-Raya JJ
Cáceres C
Montero-Alía P
Montero-Alía JJ
Jimenez-Gonzalez MM
Hernández-Pérez M
Perera-Lluna A
Grove GA
Munuera J
Domènech S
Erickson KI
Mataró M
author_role author
author2 Roig-Coll F
Lamonja-Vicente N
Altés-Magret M
Torán-Monserrat P
Via M
García-Molina A
Tormos JM
Heras A
Alzamora MT
Forés R
Pera G
Dacosta-Aguayo R
Soriano-Raya JJ
Cáceres C
Montero-Alía P
Montero-Alía JJ
Jimenez-Gonzalez MM
Hernández-Pérez M
Perera-Lluna A
Grove GA
Munuera J
Domènech S
Erickson KI
Mataró M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv computer-based cognitive training
aerobic exercise
neuroplasticity
neuroimaging
biomarkers
physically inactive
aging
fitness
topic computer-based cognitive training
aerobic exercise
neuroplasticity
neuroimaging
biomarkers
physically inactive
aging
fitness
description Introduction: Age-related health, brain, and cognitive impairment is a great challenge in current society. Cognitive training, aerobic exercise and their combination have been shown to benefit health, brain, cognition and psychological status in healthy older adults. Inconsistent results across studies may be related to several variables. We need to better identify cognitive changes, individual variables that may predict the effect of these interventions, and changes in structural and functional brain outcomes as well as physiological molecular correlates that may be mediating these effects. Projecte Moviment is a multi-domain randomized trial examining the effect of these interventions applied 5 days per week for 3 months compared to a passive control group. The aim of this paper is to describe the sample, procedures and planned analyses. Methods: One hundred and forty healthy physically inactive older adults will be randomly assigned to computerized cognitive training (COT), aerobic exercise (AE), combined training (COMB), or a control group. The intervention consists of a 3 month home-based program 5 days per week in sessions of 45 min. Data from cognitive, physical, and psychological tests, cardiovascular risk factors, structural and functional brain scans, and blood samples will be obtained before and after the intervention. Results: Effects of the interventions on cognitive outcomes will be described in intention-to-treat and per protocol analyses. We will also analyze potential genetic, demographic, brain, and physiological molecular correlates that may predict the effects of intervention, as well as the association between cognitive effects and changes in these variables using the per protocol sample. Discussion: Projecte Moviment is a multi-domain intervention trial based on prior evidence that aims to understand the effects of CCT, AE, and COMB on cognitive and psychological outcomes compared to a passive control group, and to determine related biological correlates and predictors of the intervention effects.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16577
https://www.frontiersin.org/articles/10.3389/fnagi.2019.00216/full
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16577
https://www.frontiersin.org/articles/10.3389/fnagi.2019.00216/full
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Aging Neuroscience
ISSN: 16634365
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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