A novel methodology for the determination of neutral perfluoroalkyl and polyfluoroalkyl substances in water by gas chromatographyatmospheric pressure photoionisation-high resolution mass spectrometry
Here, we developed and validated a new gas chromatography-atmospheric pressure photoionisation high-resolution mass spectrometry (GC-APPI-HRMS) method combined with headspace solid-phase microextraction (HS-SPME) for the determination of neutral perfluoroalkyl and polyfluoroalkyl substances (PFASs)...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/225914 |
| Acceso en línea: | https://hdl.handle.net/2445/225914 |
| Access Level: | acceso abierto |
| Palabra clave: | Cromatografia de gasos Ionització Espectrometria de masses Gas chromatography Ionization Mass spectrometry |
| Sumario: | Here, we developed and validated a new gas chromatography-atmospheric pressure photoionisation high-resolution mass spectrometry (GC-APPI-HRMS) method combined with headspace solid-phase microextraction (HS-SPME) for the determination of neutral perfluoroalkyl and polyfluoroalkyl substances (PFASs) in water samples. The method includes fluorotelomer olefins (FTOs), fluorotelomer alcohols (FTOHs), fluoroctanesulfonamides (FOSAs) and sulfonamido-ethanols (FOSEs). The feasibility of the GC-APPI interface for the ionisation of the target compounds was evaluated, achieving the best results using negative-ion dopant-assisted ionisation with acetone and a source and capillary temperatures of 225 oC and 175 oC, respectively. Under optimal conditions, FTOs and FTOHs mass spectra showed intense in-source CID fragment ions from the fluoroalkyl chain but also the superoxide [M+O2]-· adduct ion. For FOSAs, [M-H]- was the main ion generated, while FOSEs mass spectra showed fragment ions corresponding to the different cleavages of the functional group. The high ionisation efficiency achieved with the GC-APPI interface provided limits of the detection lower than those obtained using traditional GC-MS ionisation techniques, with a high sensitivity, selectivity and precision. For water analysis, a fast and simple HS-SPME procedure was developed, avoiding evaporation steps, which could lead to the loss of the most volatile compounds. The developed HS-SPME GC-APPI-HRMS method showed a good analytical performance for the analysis of river water samples, providing very low limits of detection (0.02e15 ng L 1), good repeatability (RSD < 11%) and trueness (relative error < 12%). |
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